Penn Medicine Provider
Mitchell A. Lazar, MD, PhD

About me

  • Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
  • Professor of Medicine in Genetics

Education and training

  • Medical School: Stanford University School of Medicine
  • Residency: Massachusetts General Hospital/Brigham and Women’s Hospital
  • Fellowship: Massachusetts General Hospital

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Lazar is a Penn Medicine physician.

Qualifications and experience

My research

Bhattarai B, Antonova AU, Fachi JL, Hopkins LS, McCullen MVD, Saini A, Oliveira S, Beatty WL, Musiek ES, Kuchroo VK, Lazar MA, Oltz EM, Colonna M. Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt. , Nat Immunol. : 2025


Deota S, Pendergast JS, Kolthur-Seetharam U, Esser KA, Gachon F, Asher G, Dibner C, Benitah SA, Escobar C, Muoio DM, Zhang EE, Hotamışlıgil GS, Bass J, Takahashi JS, Rabinowitz JD, Lamia KA, de Cabo R, Kajimura S, Longo VD, Xu Y, Lazar MA, Verdin E, Zierath JR, Auwerx J, Drucker DJ, Panda S. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. , Nat Metab, 7(3): 2025,454-468


Woodie LN, Alberto AJ, Krusen BM, Melink LC, Lazar MA. Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease. , Proc Natl Acad Sci U S A., 121(51): 2024,e2417678121


Woodie LN, Melink LC, Midha M, de Araújo AM, Geisler CE, Alberto AJ, Krusen, BM, Zundell DM, de Lartigue G, Hayes MR, Lazar MA. Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake. , Science, 386(6722): 2024,:673-677


Inoue SI, Emmett MJ, Lim HW, Midha M, Richter HJ, Celwyn IJ, Mehmood R, Chondronikola M, Klein S, Hauck AK, Lazar MA. Short-term cold exposure induces persistent epigenomic memory in brown fat. , Cell Metab. , 36(8): 2024,1764-1778


Paneru BD, Chini J, McCright SJ, DeMarco N, Miller J, Joannas LD, Henao-Mejia J, Titchenell PM, Merrick DM, Lim HW, Lazar MA, Hill DA. Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity. , Nat Commun. , 15(1): 2024,5394


Hauck AK, Mehmood R, Carpenter BJ, Frankfurter MT, Tackenberg MC, Inoue SI, Krieg MK, Cassim Bawa FN, Midha MK, Zundell DM, Batmanov K, Lazar MA. Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis. , Nat Metab. , 6(5): 2024,825-836


Woodie LN, Melink LC, Alberto AJ, Burrows M, Fortin SM, Chan CC, Hayes MR, Lazar MA. Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet- induced obesity and brown adipose tissue pathophysiology. , Mol Metab., 79: 2024,Article 101861


Woodie LN, Melink LC, Midha M, de Araújo AM, Geisler CE, Alberto AJ, Krusen, BM, Zundell DM, de Lartigue G, Hayes MR, Lazar MA. Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake. , bioRxiv[Preprint]: 2023


Latimer MN, Williams LJ, Shanmugan G, Carpenter BJ, Lazar MA, Dierickx P, Young ME. Cardiomyocyte-specific disruption of the circadian BMAL1-REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart. , Commun Biol, 6(1): 2023,1149


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