Find a Doctor or Practice Location

Are you a referring physician?
within
I am searching for a
Reset Form
Mitchell A. Lazar, MD, PhD

Mitchell A. Lazar, MD, PhD Physician

Chief, Endocrinology, Diabetes and Metabolism Division
Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
Professor of Genetics

Dr. Lazar is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Medicine
    • Diabetes, Endocrinology and Metabolism

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 1987
  • Internal Medicine, 1985

Clinical Expertise:

  • Thyroid Cancer

Practice Locations and Appointments

  • Penn Endocrinology

    Perelman Center for Advanced Medicine West Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Stanford University School of Medicine
Residency: Brigham and Women's Hospital
Fellowship: Massachusetts General Hospital

Memberships

American Academy of Arts and Sciences, National American Association for the Advancement of Science, National American Diabetes Association, National American Federation of Medical Research, National American Society for Clinical Investigation, National American Thyroid Association, National Association of American Physicians, National Eli Lilly, National Institute of Medicine, National Novartis, National Searle Scholars Program, National The Endocrine Society, National

Hospital Affiliation

Dr. Lazar is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research Interests
Epigenomic regulation of transcription and metabolism by nuclear receptors; mechanism of obesity-associated insulin resistance and diabetes; circadian regulation of metabolism

Key words: diabetes, endocrinology, epigenomics, nuclear receptors, circadian rhythms

Description of Research
The Lazar laboratory is studying the transcriptional regulation of metabolism. We are particularly focused on the role played by nuclear receptors (NRs). In the absence of ligand, NRs bind to DNA and function as potent transcriptional repressors by recruiting corepressor complexes that include the chromatin modulating enzyme histone deacetylase 3 (HDAC3). We are studying the tissue-specific and physiological roles of the corepressor complexes using by combining genomic, genetic, proteomic, bioinformatic, and metabolic phenotyping approaches. We are especially interested in the circadian NR Rev-erb alpha, which utilizes the corepressor complex to potently repress transcription. Rev-erb alpha is a key repressive component of the circadian clock that coordinates metabolism and biological rhythms. We are also studying PPAR gamma, a nuclear receptor that is a master regulator of adipocyte (fat cell) differentiation. Ligands for PPAR gamma have potent antidiabetic activity, and thus PPAR gamma represents a key transcriptional link between obesity and diabetes. The molecular, cellular, and integrative biology of these factors are being studied in mice and humans. We also have discovered resistin, a novel hormone and target of PPAR gamma that is made by fat cells in rodents and by macrophages in humans, and are testing the hypothesis that resistin links metabolism to inflammation in human metabolic diseases.


Rotation Projects for 2016-2017
There are numerous potential projects that I would be pleased to discuss in person.

Lab personnel:
David Steger, Ph.D. (Research Assistant Professor)
Sean Armour, Ph.D. (Post-doc)
Romeo Papazyan, Ph.D. (Post-doc)
Victoria Nelson, Ph.D. (Post-doc)
Paul Titchenell, Ph.D. (Post-doc)
Dongyin Guan, Ph.D. (Post-doc)
David Hill, M.D., Ph.D. (Post-doc)
Zhenghui Li, Ph.D. (Post-doc)
Marine Adlanmerini, Ph.D. (Post-doc)
Wenxiang Hu, Ph.D. (Post-doc)
Matthew Emmett (Graduate Student)
Jarrett Remsberg (Graduate Student)
Yuxiang Zhang (Graduate Student)
Yong Hoon Kim (Graduate Student)
Patricia Borck (Graduate Student)
Erika Briggs (Research Specialist)
Lindsey Peed(Research Specialist)
Manashree Damle (Bioinformatics Research Specialist)
Yee Hoon Foong (Research Specialist)
Wesley Ho (Research Specialist)
Joe Weaver (Lab Manager)

Selected Publications:

Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD.: Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chem Biol. : [Epub ahead of print],2016.

Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA.: HNF6 and Rev-erba integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Genes Dev. 30 (14): 1636-44,2016.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Richard Lu Q.: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell. 37 (6): doi: 10.1016/j.devcel.2016.06.004.,2016.

Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.: The Nuclear Receptor Rev-erba Regulates Adipose Tissue-Specific Fibroblast Growth Factor 21 (FGF21) Signaling. J Biol Chem. 291 (20): 10867-75,2016.

Wang Y, Frank DB, Morley MP, Zhou S, Wang X, Lu MM, Lazar MA, Morrisey EE.: HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-ß Signaling Regulation. Dev Cell 36 (3): 303-15,2016.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR.: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Dev Cell 36 (3): 316-30,2016.

Gerhart-Hines Z, Lazar MA.: Rev-erba and the circadian transcriptional regulation of metabolism. Diabetes Obes Metab. Suppl 1 : 12-6,2015.

Fang B, Lazar MA.: Dissecting the Rev-erba Cistrome and the Mechanisms Controlling Circadian Transcription in Liver. Cold Spring Harb Symp Quant Biol. : pii: 027508. [Epub ahead of print],2015.

Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV.: MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells Cell Metab : 2015.

Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, Voight BF, Lazar MA.: Genetic Variation Determines PPAR? Function and Anti-diabetic Drug Response In Vivo. Cell 162 (1): 33-44,2015.

View all publications

Academic Contact Info

12-102 Smilow Center for Translational Research
3400 Civic Center Boulevard / 5160

Philadelphia, PA 19104-5160
Phone: (215) 898-0198
Fax: (215) 898-5408
Patient appointments: 800-789-PENN (7366)

Related Links