Penn Medicine Provider
Mitchell A. Lazar, MD, PhD
About me
- Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
- Professor of Medicine in Genetics
Education and training
- Medical School: Stanford University School of Medicine
- Residency: Massachusetts General Hospital/Brigham and Women’s Hospital
- Fellowship: Massachusetts General Hospital
My Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Qualifications and experience
- Endocrinology, Diabetes, & Metabolism, 1987
- Internal Medicine, 1985
- American Academy of Arts and Sciences, National
- American Association for the Advancement of Science, National
- American Diabetes Association, National
- American Federation of Medical Research, National
- American Society for Clinical Investigation, National
- American Thyroid Association, National
- Association of American Physicians, National
- Institute of Medicine, National
- National Academy of Sciences, National
- Pfizer, National
- Scientific Advisory Board, Flare Therapeutics, National
- The Endocrine Society, National
My research
Inoue SI, Emmett MJ, Lim HW, Midha M, Richter HJ, Celwyn IJ, Mehmood R, Chondronikola M, Klein S, Hauck AK, Lazar MA. Short-term cold exposure induces persistent epigenomic memory in brown fat. , Cell Metab. , 36(8): 2024,1764-1778
Paneru BD, Chini J, McCright SJ, DeMarco N, Miller J, Joannas LD, Henao-Mejia J, Titchenell PM, Merrick DM, Lim HW, Lazar MA, Hill DA. Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity. , Nat Commun. , 15(1): 2024,5394
Hauck AK, Mehmood R, Carpenter BJ, Frankfurter MT, Tackenberg MC, Inoue SI, Krieg MK, Cassim Bawa FN, Midha MK, Zundell DM, Batmanov K, Lazar MA. Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis. , Nat Metab. , 6(5): 2024,825-836
Woodie LN, Melink LC, Alberto AJ, Burrows M, Fortin SM, Chan CC, Hayes MR, Lazar MA. Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet- induced obesity and brown adipose tissue pathophysiology. , Mol Metab., 79: 2024,Article 101861
Woodie LN, Melink LC, Midha M, de Araújo AM, Geisler CE, Alberto AJ, Krusen, BM, Zundell DM, de Lartigue G, Hayes MR, Lazar MA. Hepatic Vagal Afferents Convey Clock-Dependent Signals to Regulate Circadian Food Intake. , bioRxiv[Preprint]: 2023
Latimer MN, Williams LJ, Shanmugan G, Carpenter BJ, Lazar MA, Dierickx P, Young ME. Cardiomyocyte-specific disruption of the circadian BMAL1-REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart. , Commun Biol, 6(1): 2023,1149
Zhu K, Celwyn IJ, Guan D, Xiao Y, Wang X, Hu W, Jiang C, Cheng L, Casellas R, Lazar MA. An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver. , Mol Cell. , 83(19): 2023,3457-3469.e7
Lee J, Dimitry JM, Song JH, Son M, Sheehan PW, King MW, Travis Tabor G, Goo, YA, Lazar MA, Petrucelli L, Musiek ES. Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice. , Nat Commun, 14(1): 2023,5197
Mia S, Sonkar R, Williams L, Latimer MN, Rawnsley DR, Rana S, He J, Dierickx, P, Kim T, Xie M, Habegger KM, Kubo M, Zhou L, Thomsen MB, Prabhu SD, Frank SJ, Brookes PS, Lazar MA, Diwan A, Young ME. Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology. , JACC Basic Transl Sci. , 8(9): 2023,1141-1156
Yamamoto T, Maurya SK, Pruzinsky E, Batmanov K, Xiao Y, Sulon SM, Sakamoto T, Wang Y, Lai L, McDaid KS, Shewale SV, Leone TC, Koves TR, Muoio DM, Dierickx P, Lazar MA, Lewandowski ED, Kelly DP. RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure. , J Clin Invest, 133(9): 2023,e162309