Description of Research Expertise
During fellowship training, Dr. Sims completed a Masters Degree in Clinical Epidemiology at the University of Pennsylvania, studying the functional consequences of secondary pulmonary hypertension in patients with severe COPD. After completing his fellowship training, he went on to be the principal investigator of a K23 award from the NIH/NHLBI investigating surfactant protein D as a modulator of lung inflammation and COPD pathogenesis. In addition, he has been actively involved in multiple clinical and translational studies of biomarkers and novel therapies for COPD as well as bronchoscopic treatments for severe emphysema. In 2013, Dr. Sims redirected his career to focus on the clinical care of advanced COPD, and now serves as the Clinical Director of the Penn COPD Program.
Selected Publications
Jacob A. Martin, Andrew Crane-Droesch, Folasade C. Lapite, Joseph C. Puhl, Tyler E. Kmiec, Jasmine A. Silvestri, Lyle H. Ungar, Bruce P. Kinosian, Blanca E. Himes, Rebecca A. Hubbard, Joshua M. Diamond, Vivek Ahya, Michael W. Sims, Scott D. Halpern, Gary E. Weissman: Development and validation of a prediction model for actionable aspects of frailty in the text of clinicians' encounter notes J Am Med Inform Assoc 29 (1): 109-19,2021.
Atochina-Vasserman EN, Guo C-J, Abramova E, Golden TN, Sims MW, James ML, Beers MF, Gow AJ, Krymskaya VP: Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis American Journal of Respiratory Cell and Molecular Biology 53 (1): 96-104,2015.
Sims MW: Acute respiratory failure due to chronic obstructive pulmonary disease The Intensive Care Unit Manual, 2nd Edition : 715-22,2014.
Lipson DA, Holsclaw D, Imbesi G, Ferrin M, Sims MW, Miller S, Tal-Singer R, Hadjiliadis D: Evidence of Elevated CXCR2 Agonists in Stable Outpatients with Cystic Fibrosis Compared with Healthy Controls Journal of Pulmonary and Respiratory Medicine 3 (3): 149,2013.
Sims MW: Bullous lung disease Clinical Decision Support in Medicine - Epub : 2013.
Sims MW: Aerosol therapy for obstructive lung diseases: device selection and practice management issues Chest 140 (3): 781–788,2011.
Sims MW, Panettieri RA: Profile of aclidinium bromide in the treatment of chronic obstructive pulmonary disease International Journal of COPD 6 (1): 457-66,2011.
Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille K, Lama V, Shah PD, Orens JB, Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy S, Christie JD, and Ware LB for the Lung Transplant Outcomes Group: Effect of Single versus Bilateral Lung Transplantation on Plasma Surfactant Protein D Levels in Idiopathic Pulmonary Fibrosis Chest 140 (2): 489-96,2011.
Amrani Y, Syed F, Huang C, Li K, Liu V, Jain D, Keslacy S, Sims MW, Baidouri H, Cooper PR, Zhao H, Siddiqui S, Brightling CE, Griswold D, Li L, Panettieri RA: Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13 Respiratory Research 11 : 104,2010.
Sims MW, Beers MF, Ahya VN, Kawut SM, Sims KD, Lederer DJ, Palmer SM, Wille K, Lama V, Shah PD, Orens JB Bhorade S, Crespo M, Weinacker A, Demissie E, Bellamy S, Christie JD, and Ware LB for the Lung Transplant Outcomes Group: Effect of Single versus Bilateral Lung Transplantation on Plasma Surfactant Protein D Levels in Idiopathic Pulmonary Fibrosis Abstract selected for poster discussion at 2010 ATS Conference : 2010.
Academic Contact Information
3737 Market Street, 10th floor
Philadelphia,
PA
19104
Phone: 215-662-8585
Patient appointments: 800-789-7366