Description of Research Expertise
Dr. Shashaty's career is focused on epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI), in critical illness and populations.
Dr. Shashaty has formal training in the clinical practice of pulmonary and critical care medicine, biostatistical and epidemiologic methods, and protein, gene expression, and genomic analyses of human biospecimens. He is the principal investigator for the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1800) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation.
Dr. Shashaty is also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1300), and a co-investigator in Penn’s Molecular Epidemiology of Severe Sepsis in the ICU (MESSI) cohort, for which he leads studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, the relevance of programmed cell necrosis in human AKI and ARDS, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, and genetic risk factors for AKI.
Anderson MR, Cantu E, Shashaty M, Benvenuto L, Kalman L, Palmer S, Singer JP, Gallop R, Diamond JM, Hsu J, Localio AR, Christie JD.: Body Mass Index and Cause-specific Mortality after Lung Transplantation in the United States Ann Am Thorac Soc : 2023.
CV Cosgriff, TA Miano, D Mathew, AC Huang, HM Giannini, L Kuri-Cervantes, MB Pampena, CAG Ittner, AR Weisman, RS Agyekum, TG Dunn, O Oniyide, AP Turner, K D’Andrea, S Adamski, AR Greenplate, BJ Anderson, MO Harhay, TK Jones, JP Reilly, NS Mangalmurti, MGS Shashaty, MR Betts, EJ Wherry, NJ Meyer: Validating a Proteomic Signature of Severe COVID-19 Critical Care Explorations 4 (12): e0800,2022.
Mitchell OJL, Neefe S, Ginestra JC, Schweickert WD, Falk S, Weissman GE, Covin D, Shults J, Abella BS, Shashaty MGS.: Association of Time to Rapid Response Team Activation With Patient Outcomes Using a Range of Physiologic Deterioration Thresholds Crit Care Explor 4 : e0786,2022.
Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS.: Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study Intensive Care Med : 2022.
Pike DP, McGuffee RM, Geerling E, Albert CJ, Hoft DF, Shashaty MGS, Meyer NJ, Pinto AK, Ford DA: Plasmalogen Loss in Sepsis and SARS-CoV-2 Infection Frontiers in Cell and Developmental Biology 10 : 2022.
Mitchell OJL, Dewan M, Wolfe HA, Roberts KJ, Neefe S, Lighthall G, Sands NA, Weissman G, Ginestra J, Shashaty MGS, Schweickert WD, Abella BS: Defining Physiological Decompensation: An Expert Consensus and Retrospective Outcome Validation Critical Care Explorations 4 (4): e0677,2022.
Faust HE, Oniyide O, Wang Y, Forker CM, Dunn T, Yang W, Lanken PN, Sims CA, Yehya N, Christie JD, Meyer NJ, Reilly JP, Mangalmurti NS, Shashaty MGS: Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations are Associated with Acute Kidney Injury in Critically Ill Trauma Patients Critical Care Explorations : 2022.
Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Weisman AR, Agyekum R, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ.: Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate With Organ Dysfunction and Mortality in Sepsis Shock 57 : 41-47,2022.
Amunugama K, Jellinek MJ, Kilroy MP, Albert CJ, Rasi V, Hoft DF, Shashaty MGS, Meyer NJ, Ford DA.: Identification of novel neutrophil very long chain plasmalogen molecular species and their myeloperoxidase mediated oxidation products in human sepsis Redox Biol 48 : 102208,2021.
Wu J, Ma Z, Raman A, Beckerman P, Dhillon P, Mukhi D, Palmer M, Chen HC, Cohen CR, Dunn T, Reilly J, Meyer N, Shashaty M, Arany Z, Haskó G, Laudanski K, Hung A, Susztak K.: APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis Immunity 54 : 2632-2649,2021.
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Academic Contact Information
5039 W Gates
Hospital of the University of Pennsylvania
3400 Spruce Street