Penn Medicine Provider
Pulmonary Medicine
Michael G. S. Shashaty, MD, MSCE
Sees patients age 18 and up
Harron Lung Center - Inpatient Care
Call 800-789-7366

About me

  • Medical Director, Rapid Response, Hospital of the University of Pennsylvania
  • Associate Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania

My career is focused in critical care medicine, clinical emergencies, and epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI).

Trained in internal medicine, pulmonary diseases, and critical care medicine, I practice clinically in the medical intensive care unit (ICU) and with the Critical Care Outreach and Procedure Service (CCOPS) at the Hospital of the University of Pennsylvania (HUP). I am the CCOPS service lead and Rapid Response Medical Director at HUP, working with a multidisciplinary team to provide oversight, to design and conduct training, and to pursue quality improvement initiatives in clinical emergencies and bedside procedures. Our team also conducts research designed to better recognize and rescue non-ICU inpatients with incipient critical illness.

I am the principal investigator of the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1900) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation.

I am also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1400), and a co-investigator in Penn’s Molecular Epidemiology of Sepsis in the ICU (MESSI) cohort, for which I lead studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, genetic risk factors for AKI, and.drug nephrotoxicity in critical illness.

These research and clinical efforts are supported by a large number of outstanding mentors, colleagues, mentees, and trainees with whom I have the great fortune to work and from whom I am constantly learning.

Education and training

  • Medical School: Vanderbilt University
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Learn about location

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Shashaty is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Reilly JP, Shashaty MGS, Miano TA, Giannini HM, Jones TK, Ittner CAG, Christie JD, Meyer NJ. ABO Histo-Blood Group and the von Willebrand Factor Axis in Severe COVID-19 , CHEST Crit Care: 2023

Diamond JM, Anderson MR, Cantu E, Clausen ES, Shashaty MGS, Kalman L, Oyster, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Lama VN, Patel MG, Singer JP, Hachem RR, Michelson AP, Hsu J, A Russell Localio AR, Christie JD Development and Validation of Primary Graft Dysfunction Predictive Algorithm for Lung Transplant Candidates , Journal of Heart and Lung Transplantation: 2023

Diamond JM, Cantu E, Calfee CS, Anderson MR, Clausen ES, Shashaty MGS, Courtwright AM, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Todd JL, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Weinacker AB, Lama VN, Patel MG, Singer JP, Hsu J, Localio AR, Christie JD. The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation , Am J Respir Crit Care Med: 2023

Anderson MR, Diamond J, Shashaty M, Singer JP, Tong Y, Udupa J, Torigian DA, Palmer S, Lederer DJ, Christie JD, Al-Naamani N. Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study , Ann Am Thorac Soc, 20(9): 2023,1363-1366

Jones TK, Reilly JP, Anderson BJ, Miano TA, Dunn TG, Turner AP, Agyekum RS, Feng R, Ittner CAG, Shashaty MGS, Meyer NJ. Acute Respiratory Distress Syndrome Mediates the Association between Early Plasma Soluble Receptor for Advanced Glycation End Products Concentrations and Mortality in Sepsis , Am J Respir Crit Care Med, 208: 2023,628-630

Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB. Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis , Intensive Care Med: 2023

Anderson MR, Cantu E, Shashaty M, Benvenuto L, Kalman L, Palmer S, Singer JP, Gallop R, Diamond JM, Hsu J, Localio AR, Christie JD. Body Mass Index and Cause-specific Mortality after Lung Transplantation in the United States , Ann Am Thorac Soc, 20(6): 2023,825-833

CV Cosgriff, TA Miano, D Mathew, AC Huang, HM Giannini, L Kuri-Cervantes, MB Pampena, CAG Ittner, AR Weisman, RS Agyekum, TG Dunn, O Oniyide, AP Turner, K D’Andrea, S Adamski, AR Greenplate, BJ Anderson, MO Harhay, TK Jones, JP Reilly, NS Mangalmurti, MGS Shashaty, MR Betts, EJ Wherry, NJ Meyer Validating a Proteomic Signature of Severe COVID-19 , Critical Care Explorations, 4(12): 2022,e0800

Mitchell OJL, Neefe S, Ginestra JC, Schweickert WD, Falk S, Weissman GE, Covin D, Shults J, Abella BS, Shashaty MGS. Association of Time to Rapid Response Team Activation With Patient Outcomes Using a Range of Physiologic Deterioration Thresholds , Crit Care Explor, 4: 2022,e0786

Miano TA, Hennessy S, Yang W, Dunn TG, Weisman AR, Oniyide O, Agyekum RS, Turner AP, Ittner CAG, Anderson BJ, Wilson FP, Townsend R, Reilly JP, Giannini HM, Cosgriff CV, Jones TK, Meyer NJ, Shashaty MGS. Association of vancomycin plus piperacillin-tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study , Intensive Care Med: 2022

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