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Michael R. Rickels, MD, MS

Michael R. Rickels, MD, MS Physician

Medical Director, Pancreatic Islet Cell Transplant Program Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Rickels is employed by Penn Medicine.

About Dr. Michael R. Rickels

Recognized in Philadelphia magazine's May 2019 Top Docs issue

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Diabetes

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 2004

Clinical Expertise:

  • Abnormal Glucose Metabolism
  • Diabetes
  • Diabetes Education
  • Diabetic Coma
  • Diabetic Ketoacidosis
  • Hyperglycemia
  • Hypoglycemia
  • Insulin Pump
  • Insulinoma
  • Polyglandular Autoimmune Syndrome
  • Type 1 Diabetes
  • Type 2 Diabetes

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Association of Clinical Endocrinologists, National American Diabetes Association, National Collaborative Islet Transplant Registry, Rockville, MD, International International Pancreas and Islet Transplant Association, International Juvenile Diabetes Research Foundation International, New York, NY, International National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, MD, National The Endocrine Society, National Type 1 Diabetes (T1D) Exchange Clinic Network, Jaeb Center for Health Research, Tampa, FL, National

Hospital Affiliation

Dr. Rickels is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Rickels conducts patient-oriented diabetes research that aims at understanding the pathogenesis of various forms of diabetes and the in vivo mechanisms of new diabetes treatments, and is in particular focused on islet function and replacement in type 1 diabetes and pancreatogenic forms of diabetes. Dr. Rickels' studies involve methodologies for quantifying insulin and incretin secretion, insulin sensitivity, and glucose counterregulatory responses to hypoglycemia, and include oral glucose and mixed-meal tolerance tests, the frequently-sampled intravenous glucose tolerance test, the glucose-potentiated arginine test, and hyperinsulinemic euglycemic and hypoglycemic clamps. Present work in type 1 diabetes is focused on understanding the mechanisms of defective glucose counterregulation and novel approaches to the prevention or correction of hypoglycemia, including by beta-cell replacement (islet transplantation) therapy or artificial pancreas (closed-loop) technology. Present work in cystic fibrosis-related diabetes is directed at understanding the pathophysiologic defects involved in the etiology of early defects in insulin secretion and the impact of different strategies for enhancing incretin effects on beta-cell function.

Selected Publications:

Vantyghem MC, de Koning EJP, Pattou F, Rickels MR: Advances in beta-cell replacement therapy for the treatment of type 1 diabetes Lancet 394 (10205): 1274-1285,2019.

Rickels MR: Hypoglycemia associated autonomic failure, counterregulatory responses, and therapeutic options in type 1 diabetes Annals of the New York Academy of Sciences 1454 (1): 68-79,2019.

Rickels MR, Robertson RP: Pancreatic islet transplantation in humans: recent progress and future directions Endocrine Reviews 40 (2): 631-688,2019.

Kelly A, De Leon DD, Sheikh S, Camburn D, Kubrak C, Peleckis AJ, Stefanovski D, Hadjiliadis D, Rickels MR, Rubenstein RC: Islet hormone and incretin secretion in cystic fibrosis after four months of ivacaftor therapy American Journal of Respiratory and Critical Care Medicine 199 (3): 342-351,2019.

Foster NC, Beck RW, Miller KM, Clements MA, Rickels MR, DiMeglio LA, Maahs DM, Tamborlane WV, Bergenstal R, Smith E, Olson BA, Garg SK; T1D Exchange Clinic Network: State of type 1 diabetes management and outcomes from the T1D Exchange in 2016-2018 Diabetes Technology & Therapeutics 21 (2): 66-72,2019.

Korutla L, Rickels MR, Hu RW, Habertheuer A, Reddy S, Freas A, Harmon J, Korutla V, Ram C, Naji A, Vallabhajosyula P: Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation American Journal of Transplantation 19 (6): 1852-1858,2019.

Nyirjesy SC, * Sheikh S, * Hadjiliadis D, De Leon DD, Peleckis AJ, Eiel JN, Kubrak C, Stefanovski D, Rubenstein RC, Rickels MR, Kelly A: Beta-cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose ≥155 mg/dl Pediatric Diabetes 19 (7): 1173-1182,2018.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A: Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells Transplantation 102 (8): 1223-1229,2018.

Rickels MR, DuBose SN, Toschi E, Beck RW, Verdejo AS, Wolpert H, Cummins MJ, Newswanger B, Riddell MC; T1D Exchange Mini-Dose Glucagon Exercise Study Group: Mini-dose glucagon as a novel approach to prevent exercise-induced hypoglycemia in type 1 diabetes Diabetes Care 41 (9): 1909-1916,2018.

Rickels MR, Peleckis AJ, Dalton-Bakes C, Naji JR, Ran NA, Nguyen H-L, O'Brien S, Chen S, Lee I, Schutta MH: Continuous glucose monitoring for hypoglycemia avoidance and glucose counterregulation in long-standing type 1 diabetes Journal of Clinical Endocrinology & Metabolism 103 (1): 105-114,2018.

View all publications

Academic Contact Info

12-134 Smilow Center for Translational Research
3400 Civic Center Boulevard

Philadelphia, Pa 19104
Phone: (215) 746-0025
Patient appointments: 800-789-7366 (PENN)

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