Description of Research Expertise:
Dr. Rickels conducts patient-oriented diabetes research that aims at understanding the pathogenesis of various forms of diabetes and the in vivo mechanisms of new diabetes treatments, and is in particular focused on islet function and replacement in type 1 diabetes and pancreatogenic forms of diabetes. Dr. Rickels' studies involve methodologies for quantifying insulin and incretin secretion, insulin sensitivity, and glucose counterregulatory responses to hypoglycemia, and include oral glucose and mixed-meal tolerance tests, the frequently-sampled intravenous glucose tolerance test, the glucose-potentiated arginine test, and hyperinsulinemic euglycemic and hypoglycemic clamps. Present work in type 1 diabetes is focused on understanding the mechanisms of defective glucose counterregulation and novel approaches to the prevention or correction of hypoglycemia, including by beta-cell replacement (islet transplantation) therapy or artificial pancreas (closed-loop) technology. Present work in cystic fibrosis-related diabetes is directed at understanding the pathophysiologic defects involved in the etiology of early defects in insulin secretion and the impact of different strategies for enhancing incretin effects on beta-cell function.
Vantyghem MC, de Koning EJP, Pattou F, Rickels MR: Advances in beta-cell replacement therapy for the treatment of type 1 diabetes Lancet 394 (10205): 1274-1285,2019.
Rickels MR: Hypoglycemia associated autonomic failure, counterregulatory responses, and therapeutic options in type 1 diabetes Annals of the New York Academy of Sciences 1454 (1): 68-79,2019.
Rickels MR, Robertson RP: Pancreatic islet transplantation in humans: recent progress and future directions Endocrine Reviews 40 (2): 631-688,2019.
Kelly A, De Leon DD, Sheikh S, Camburn D, Kubrak C, Peleckis AJ, Stefanovski D, Hadjiliadis D, Rickels MR, Rubenstein RC: Islet hormone and incretin secretion in cystic fibrosis after four months of ivacaftor therapy American Journal of Respiratory and Critical Care Medicine 199 (3): 342-351,2019.
Foster NC, Beck RW, Miller KM, Clements MA, Rickels MR, DiMeglio LA, Maahs DM, Tamborlane WV, Bergenstal R, Smith E, Olson BA, Garg SK; T1D Exchange Clinic Network: State of type 1 diabetes management and outcomes from the T1D Exchange in 2016-2018 Diabetes Technology & Therapeutics 21 (2): 66-72,2019.
Korutla L, Rickels MR, Hu RW, Habertheuer A, Reddy S, Freas A, Harmon J, Korutla V, Ram C, Naji A, Vallabhajosyula P: Noninvasive diagnosis of recurrent autoimmune type 1 diabetes after islet cell transplantation American Journal of Transplantation 19 (6): 1852-1858,2019.
Nyirjesy SC, * Sheikh S, * Hadjiliadis D, De Leon DD, Peleckis AJ, Eiel JN, Kubrak C, Stefanovski D, Rubenstein RC, Rickels MR, Kelly A: Beta-cell secretory defects are present in pancreatic insufficient cystic fibrosis with 1-hour oral glucose tolerance test glucose ≥155 mg/dl Pediatric Diabetes 19 (7): 1173-1182,2018.
Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A: Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells Transplantation 102 (8): 1223-1229,2018.
Rickels MR, DuBose SN, Toschi E, Beck RW, Verdejo AS, Wolpert H, Cummins MJ, Newswanger B, Riddell MC; T1D Exchange Mini-Dose Glucagon Exercise Study Group: Mini-dose glucagon as a novel approach to prevent exercise-induced hypoglycemia in type 1 diabetes Diabetes Care 41 (9): 1909-1916,2018.
Rickels MR, Peleckis AJ, Dalton-Bakes C, Naji JR, Ran NA, Nguyen H-L, O'Brien S, Chen S, Lee I, Schutta MH: Continuous glucose monitoring for hypoglycemia avoidance and glucose counterregulation in long-standing type 1 diabetes Journal of Clinical Endocrinology & Metabolism 103 (1): 105-114,2018.
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