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Michael R. Rickels, MD, MS

Michael R. Rickels, MD, MS Physician

Medical Director, Pancreatic Islet Cell Transplant Program
Associate Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Rickels is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Medicine
    • Diabetes, Endocrinology and Metabolism

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 2004

Clinical Expertise:

  • Diabetes
  • Hypoglycemia
  • Type 2 Diabetes

Description of Clinical Expertise

Dr. Rickels specializes in the diagnosis and treatment of diabetes, hypoglycemia disorders, and general endocrinologic problems. Dr. Rickels predominantly cares for patients with Type 1 and Type 2 Diabetes, and is particularly interested in islet and pancreas transplantation as therapies for Type 1 Diabetes, as well as islet autotransplantation for patients undergoing total pancreatectomy. Dr. Rickels serves as Medical Director for the Pancreatic Islet Cell Transplantation program at the Hospital of the University of Pennsylvania. Coupled to his research interests in islet and pancreas transplantation, and in glucose sensing and insulin pump technologies, Dr. Rickels is committed to translating complimentary approaches for cellular and artifical pancreas replacement as treatments for patients with difficult to control Type 1 and Pancreatogenic Diabetes.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Association of Clinical Endocrinologists, National American Diabetes Association, National Center for Scientific Review, National Institutes of Health, Bethesda, MD, National Data & Safety Monitoring Board, Islet-After-Kidney Transplantation Protocol, Massachusetts General Hospital, Boston, MA, National Data & Safety Monitoring Board, Restoring Insulin Secretion (RISE) Consortium, NIDDK, Bethesda, MD, National International Pancreas and Islet Transplant Association, International Janssen Research & Development, National Metabolics study subcommittee, Clinical Islet Transplantation Consortium, National Institutes of Health, Bethesda, MD, International Publications and Presentations committee, Collaborative Islet Transplant Registry, Rockville, MD, International The Endocrine Society, National Type 1 Diabetes (T1D) Exchange Clinic Network, Jaeb Center for Health Research, Tampa, FL, National Type 1 Diabetes Outcomes Program Advisory Committee, Juvenile Diabetes Research Foundation, New York, NY, National

Hospital Affiliation

Dr. Rickels is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Rickels conducts patient-oriented diabetes research that aims at understanding the pathogenesis of different types of diabetes and the in vivo mechanisms of new diabetes treatments. Dr. Rickels' studies involve methodologies for quantifying insulin secretion, insulin sensitivity, and glucose counterregulatory responses to hypoglycemia, and include the frequently-sampled intravenous glucose tolerance test, the glucose-potentiated arginine test, and hyperinsulinemic euglycemic and hypoglycemic clamps. Present work in Type 1 Diabetes is focused on patients with long-standing disease and is examining the effects of isolated islet transplantation on insulin secretion and sensitivity, and the effects of islet transplantation or real-time continuous glucose monitoring on glucose counterregulatory defenses against hypoglycemia. Current work in Type 2 Diabetes is focused on understanding early defects in insulin secretion, the impact on early impairments of different strategies for enhancing GLP-1 effects, and the mechanisms of diabetes associated with atypical antipsychotic drugs. Additional work is directed at investigating genetic determinants of insulin secretory reserve in humans and on understanding the pathophysiologic defects involved in the etiology of Cystic Fibrosis Related Diabetes in order to inform novel treatment approaches.

Selected Publications:

Rickels MR, Fuller C, Dalton-Bakes C, Markmann E, Palanjian M, Cullison K, Tiao J, Kapoor S, Liu C, Naji A, Teff KL: Restoration of glucose counterregulation by islet transplantation in long-standing type 1 diabetes Diabetes 64 (5): 1713-1718,2015.

Vetter ML, Wadden TA, Teff KL, Khan ZF, Carvajal R, Ritter S, Moore RH, Chittams JL, Iagnocco A, Murayama K, Korus G, Williams NN, Rickels MR: GLP-1 plays a limited role in improved glycemia shortly after roux-en-Y gastric bypass: a comparison with intensive lifestyle modification Diabetes 64 (2): 434-446,2015.

Rickels MR, Goeser ES, Fuller C, Lord C, Bowler AM, Doliba NM, Hegele RA, Cuchel M: Loss-of-function mutations in ABCA1 and enhanced beta-cell secretory capacity in young adults Diabetes 64 (1): 193-199,2015.

Gudipaty L, Rosenfeld N, Fuller C, Gallop R, Schutta MH, Rickels MR: Effect of exenatide, sitagliptin or glimepiride on beta-cell secretory capacity in early type 2 diabetes Diabetes Care 37 (9): 2451–2458,2014.

Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A: Insulin sensitivity index in type 1 diabetes and following human islet transplantation: comparison of the minimal model to euglycemic clamp measures American Journal of Physiology - Endocrinology and Metabolism 306 (10): E1217-E1224,2014.

Rickels MR, Kong SM, Fuller C, Dalton-Bakes C, Ferguson JF, Reilly MP, Teff KL, Naji A: Improvement in insulin sensitivity after human islet transplantation for type 1 diabetes Journal of Clinical Endocrinology & Metabolism 98 (11): E1780-E1785,2013.

Teff KL, Rickels MR, Grudziak J, Fuller C, Nguyen H-L, Rickels K: Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease Diabetes 62 (9): 3232-3240,2013.

Rickels MR, Liu C, Shlansky-Goldberg R, Soleimanpour SA, Vivek K, Kamoun M, Min Z, Markmann E, Palangian M, Dalton-Bakes C, Fuller C, Chiou AJ, Barker CF, Prak ETL, Naji A: Improvement in beta-cell secretory capacity following human islet transplantation according to the CIT07 protocol Diabetes 62 (8): 2890-2897,2013.

Weinstock RS, Xing D, Maahs DM, Michels A, Rickels MR, Peters AL, Bergenstal RM, Harris B, DuBose SN, Miller KM, Beck RW; T1D Exchange Clinic Network: Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry Journal of Clinical Endocrinology & Metabolism 98 (8): 3411-3419,2013.

Liu C, Koeberlein B, Feldman MD, Mueller R, Wang Z, Li Y, Lane K, Hoyt CC, Tomaszewski JE, Naji A, Rickels MR: Accumulation of intrahepatic islet amyloid in a non-human primate transplant model Endocrinology 153 (4): 1673-1683,2012.

Academic Contact Info

12-134 Smilow Center for Translational Research
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 746-0025
Fax: (215) 898-5408
Patient appointments: 800-789-PENN (7366)

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