Penn Medicine Provider
Gastroenterology
Michael A. Pack, MD
Accepting new patients
Sees patients age 18 and up
Penn Gastroenterology Perelman
View 3 additional locations

About me

  • Professor of Medicine (Gastroenterology)
  • Professor of Medicine in Cell and Developmental Biology

Education and training

  • Medical School: Washington University in St. Louis
  • Residency: Thomas Jefferson University Hospital
  • Fellowship: Massachusetts General Hospital

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Pack is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X SealyI, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, and Pack M Identification of a Plant Isoflavonoid that Causes Biliary Atresia , Science Translational Medicine, 7(286): 2015,286ra67


Wilkins BJ, Gong W, Pack M A novel keratin18 promoter that drives reporter gene expression in the intrahepatic and extrahepatic biliary system allows isolation of cell-type specific transcripts from zebrafish liver , Gene Expression Patterns, 14(2): 2014,62-68


Wilkins BJ, Lorent K, Matthews RP, and Pack M p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis , PLoS One, 8(10): 2013,e77670


Walters JA, Anderson JL, Bittman R, Pack M and Farber SA Visualization of lipid metabolism in the larval zebrafish intestine reveals a relationship between NPC1L1 mediated cholesterol uptake and dietary fatty acids , Chemistry and Biology, 19(7): 2012,913-25


Seiler C, Davuluri G, Abrams J, Byfield FJ, Janye PA and Pack M Smooth muscle tension induces invasive remodeling of the zebrafish intestine , PLoS Biology, 10(9): 2012,e1001385


Abrams J, Davuluri G, Seiler C, Pack M Smooth muscle caldesmon modulates peristalsis in the wild type and non-innervated zebrafish intestine , Neurogastroenterology and Motililty, 24(3): 2012,288-99


Gao N, Davuluri G, Gong W, Seiler C, Furth EE, Kaestner K and Pack M The Nuclear Pore Complex Proetin Elys is Required for Genome Stability in Mouse Intestinal Epithelial Progenitor Cells , Gastroenterology , 140(5): 2011,1547-1555


Matthews RP, Eua Claire SF, Mungier M, Lorent K, Cui Shuang, Zhang Z, Russo P and Pack M DNA Hypomethylation Causes Bile Duct Injury in Zebrafish and Is a Distinguishing Feature of Infantile Biliary Atresia , Hepatology, 3(3): 2011,905-14


Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC and Pack M. Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress. , PLoS Genetics, 4(10): 2008,e1000240


Yee NS, Gong W, Huang Y, Lorent K, Dolan AC, Maraia RJ and Pack M Mutation of RNA Polymerase III Subunit rpc2/polr3b Leads to Deficiency of the RNA Cleavage Subunit, Rpc11/Polr3k, and Disrupts Zebrafish Digestive System Development , PLOS Biology, 5(11): 2007,e312


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