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Michael C. Milone, MD, PhD

Michael C. Milone, MD, PhD Physician

Associate Director, Toxicology Laboratory Associate Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Milone is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Pathology - Clinical Pathology, 2002

Description of Clinical Expertise

Clinical Laboratory Toxicology, Therapeutic Drug Monitoring, Clinical Chemistry, Blood Banking/Transfusion Medicine, Therapeutic Apheresis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Medicine and Dentistry of New Jersey
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania
Fellowship: University of Pennsylvania School of Medicine

Memberships

American Association of Clinical Chemistry, National American Association of Immunologists, International American Society of Clinical Pathology, National American Society of Gene and Cell Therapy, National American Society of Hematology, International College of American Pathologists, National International Association of Therapeutic Drug Monitoring and Clinical Toxicology, International

Hospital Affiliation

Dr. Milone is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research in my laboratory is focused on T cell biology and applications of genetically-engineered T cells to the treatment of disease. Active research projects in my laboratory include:

1) Developing chimeric antigen receptors (CARs) for adoptive immunotherapy of cancer with enhanced function and improved safety.

2) Developing and applying synthetic immunoreceptors to the treatment of immune-mediated disease.

3) Exploring the role of co-stimulatory signals in directing T cell metabolism and the way this metabolism affects T cell function within tumors.


Selected Publications:

Michael C. Milone and Bruce L. Levine: Powered and controlled T-cell production Nature Biomedical Engineering 2 : 148-150,2018.

June Carl H, O'Connor Roderick S, Kawalekar Omkar U, Ghassemi Saba and Milone Michael C: CAR T cell immunotherapy for human cancer Science 359 (6382): 1361-1365,2018.

Vijay Bhoj and Michael C. Milone: The pharmacology of T cell therapies Molecular Therapy - Methods & Clinical Development 8 : 210-221,2018.

Trofe-Clark Jennifer, Brennan Daniel C, West-Thielke Patricia, Milone Michael C, Lim Mary Ann, Neubauer Robin, Nigro Vincenza, Bloom Roy D: Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation : 2017.

Richman Sarah A, Nunez-Cruz Selene, Moghimi Babak, Li Lucy Z, Gershenson Zachary T, Mourelatos Zissimos, Barrett David M, Grupp Stephan A, Milone Michael C: High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer immunology research : 2017.

Kawalekar Omkar, June Carl H and Milone Michael C: Studying Immunoreceptor Signaling in Human T Cells Using Electroporation of In Vitro Transcribed mRNA Methods Molecular Biology 1584 : 443-450,2017.

Lambert Lester H, Goebrecht Geraldine K E, De Leo Sarah E, O'Connor Roddy S, Nunez-Cruz Selene, Li Tai-De, Yuan Jinglun, Milone Michael C, Kam Lance C: Improving T Cell Expansion with a Soft Touch. Nano letters 17 (2): 821-826,2017.

Ellebrecht Christoph T, Bhoj Vijay G, Nace Arben, Choi Eun Jung, Mao Xuming, Cho Michael Jeffrey, Di Zenzo Giovanni, Lanzavecchia Antonio, Seykora John T, Cotsarelis George, Milone Michael C*, Payne Aimee S*: Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353 (6295): 179-84,2016.

Bhoj Vijay G, Arhontoulis Dimitrios, Wertheim Gerald, Capobianchi James, Callahan Colleen A, Ellebrecht Christoph T, Obstfeld Amrom E, Lacey Simon F, Melenhorst Jan J, Nazimuddin Farzana, Hwang Wei-Ting, Maude Shannon L, Wasik Mariusz A, Bagg Adam, Schuster Stephen, Feldman Michael D, Porter David L, Grupp Stephen A, June Carl H, Milone Michael C: Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy. Blood 128 (3): 360-70,2016.

Kawalekar Omkar U, O'Connor Roddy S, Fraietta Joseph A, Guo Lili, McGettigan Shannon E, Posey Avery D, Patel Prachi R, Guedan Sonia, Scholler John, Keith Brian, Snyder Nathaniel, Blair Ian, Milone Michael C*, June Carl H*: Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity 44 (2): 380-90,2016.

View all publications

Academic Contact Info

3400 Spruce Street 7103 Founders Pavilion
Philadelphia, PA 19104
Phone: (215) 662-6575
Patient appointments: 800-789-7366 (PENN)