Description of Research Expertise

Dr. Kohanski’s research focuses include understanding the role of inflammatory signals in the development of sinus polyps, with a focus on rare upper respiratory epithelial cells, solitary chemosensory cells, as a source of inflammation. From his Ph.D. work on antibiotic mechanisms of action and the development of antibiotic resistance, Dr. Kohanski also has an interest in understanding the evolution of antibiotic resistance as it pertains to the use of antibiotics in the treatment of chronic rhinosinusitis. Dr. Kohanski is an author/co-author on over 50 peer reviewed scientific articles.

Selected Publications

Li Y, Renner DM, Comar CE, Whelan JN, Reyes HM, Cardenas-Diaz FL, Truitt R, Tan LH, Dong B, Alysandratos KD, Huang J, Palmer JN, Adappa ND, Kohanski MA, Kotton DN, Silverman RH, Yang W, Morrisey EE, Cohen NA, Weiss SR.: SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proc Natl Acad Sci U S A. 118 (16): 2021.

Sweis AM, Locke TB, Ig-Izevbekhai KI, Lin TC, Kumar A, Douglas JE, Corr AM, Civantos AM, Tripathi SH, Kennedy DW, Kohanski MA, Palmer JN, Adappa ND, Bosso JV.: Effectiveness of endoscopic sinus surgery and aspirin therapy in the management of aspirin-exacerbated respiratory disease. Allergy Asthma Proc. 42 (2): 136-141,2021.

Kuan EC, Kennedy WP, Patel NN, Goshtasbi K, Kohanski MA, Tong CCL, Papagiannopoulos P, Kennedy DW, Palmer JN, Adappa ND, Bosso JV.: Pre-intervention SNOT-22 scores predict outcomes in aspirin exacerbated respiratory disease. Am J Otolaryngol. 42 (5): 2021.

Locke TB, Sweis AM, Douglas JE, Ig-Izevbekhai KI, Stevens EM, Civantos AM, McCarty EB, Kumar A, Kohanski MA, Kennedy DW, Palmer JN, Bosso JV, Adappa ND.: Treatment Outcomes in Aspirin-Exacerbated Respiratory Disease Based on the 12-Item Short Form Survey. Am J Rhinol Allergy : 2021.

McMahon DB, Carey RM, Kohanski MA, Adappa ND, Palmer JN, Lee RJ.: PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol. : 2021.

Bosso JV, Tripathi SH, Kennedy DW, Kohanski MA, Cohen NA, Palmer JN, Adappa ND.: Multidisciplinary Single-center outcomes compared to two-center outcomes for the treatment of Aspirin Exacerbated Respiratory Disease. J Allergy Clin Immunol Pract. 3 ((21)00160-4): S2213-2198,2021.

Sweis AM, Locke TB, Ig-Izevbekhai KI, Lin TC, Gleeson PK, Civantos AM, Kumar A, Corr AM, Kohanski MA, Palmer JN, Bosso JV, Adappa ND.: Major complications of aspirin desensitization and maintenance therapy in aspirin-exacerbated respiratory disease. Int Forum Allergy Rhinol. 11 (2): 115-119,2021.

Kraft DO, Carey RM, Prasad A, Rajasekaran K, Kohanski MA, Kennedy DW, Palmer JN, Adappa ND, O’Malley BW Jr, Newman JG, Brant JA.: Prognosis of distant metastatic sites in anterior skull base malignancies North American Skull Base Society, Annual Meeting : 2021.

Prasad A, Carey RM, Rajasekaran K, Kohanski MA, Kennedy DW, Palmer JN, Adappa ND, O’Malley BW Jr, Brant JA, Newman JG.: Determinants of patient refusal of post-operative radiation therapy in sinonasal squamous cell carcinoma North American Skull Base Society, Annual Meeting : 2021.

Lopatkin AJ, Bening SC, Manson AL, Stokes JM, Kohanski MA, Badran AH, Earl AM, Cheney NJ, Yang JH, Collins JJ.: Clinically relevant mutations in core metabolic genes confer antibiotic resistance. Science 371 (6531): 2021.

Academic Contact Information

3400 Spruce St, 5 Ravdin
Department of Otorhinolaryngology: Head and Neck Surgery
Philadelphia, PA 19104
Phone: 215-349-5766
Patient appointments: 800-789-7366