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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
3400 Spruce Street
Philadelphia, PA 19104
My research focuses on oncologic applications of molecular imaging, with an emphasis on developing new imaging tools for the rapidly growing field of cancer immunotherapy. I am particularly interested in the development of novel radiotracers / reporter genes for CAR T cell tracking, as well as the development of radiolabeled antibodies for PET imaging of the immune system. To address these research areas, my laboratory utilizes an interdisciplinary team with expertise in a variety of scientific fields, including organic chemistry, radiochemistry, molecular biology, biochemistry, and bioengineering. Many of these translational research projects begin with in vitro studies and animal models, however the goal of every project is clinical application.
Pandit-Taskar N, Postow MA, Hellmann MD, Harding JJ, Barker CA, O'Donoghue JA, Ziolkowska M, Ruan S, Lyashchenko SK, Tsai F, Farwell M, Mitchell TC, Korn R, Le W, Lewis JS, Weber WA, Behera D, Wilson I, Gordon M, Wu AM, Wolchok JD: First-in-Humans Imaging with 89Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting. J Nucl Med. 61 (4): 512-519,2020.
Sellmyer MA, Richman SA, Lohith K, Hou C, Weng CC, Mach RH, O’Connor RS, Milone MC, Farwell MD: Imaging CAR T Cell Trafficking with eDFHR as a PET Reporter Gene. Mol Ther. 28 (1): 42-51,2020.
Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya A, Wubbenhorst B, Dorfman L, D’Andrea K, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier M, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao A, Mogg R, Xu W, Blumenschein W, Yearley JH, Linette G, Amaravadi RK, Schuchter LM, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC: A Single Dose of Neoadjuvant PD-1 Blockade Predicts Clinical Outcomes in Resectable Melanoma. Nat Med. 25 (3): 454-461,2019.
Derakhshan JJ, Farwell MD: Prevalence and quantitative analysis of indium-111 pentetreotide (Octreoscan) uptake in the pancreatic head on SPECT/CT imaging: establishing a region of interest-based pathological uptake threshold. Nucl Med Commun. 40 (7): 727-733,2019.
Shah NN, Nagle SJ, Torigian DA, Farwell MD, Hwang WT, Frey N, Nasta SD, Landsburg D, Mato A, June CH, Schuster SJ, Porter DL, Svoboda J: Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor–T-cell therapy in B-cell non-Hodgkin lymphomas. Cytotherapy. 20 (12): 1415-1418,2018.
Maity A, Mick R, Huang AC, George SM, Farwell MD, Lukens JN, Berman AT, Mitchell TC, Bauml J, Schuchter LM, O'Hara M, Lin LL, Demichele A, Christodouleas JP, Haas NB, Patsch DM, Hahn SM, Minn AJ, Wherry EJ, Vonderheide RH: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. Br J Cancer. 119 (10): 1200-1207,2018.
Lohith K, Kwon S, Padakanti P, Thanna S, Hou C, Weng CC, Sellmyer M, Mach R, Farwell M: Radiosynthesis and in vitro evaluation of [11C]Shield-1, a PET probe for imaging CAR T cells that express the iCasp9 suicide gene. J Nucl Med. 59 (Supplement 1): 61,2018.
Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest. 128 (5): 2116-2126,2018.
Ahmed HS, Pantel AR, Metz JM, Plastaras JP, Farwell MD: FDG-Avid Focal Liver Reaction From Proton Therapy in a Patient With Primary Esophageal Adenocarcinoma. Clin Nucl Med. 43 (5): e139-e141,2018.
Lohith K, Kwon S, Padakanti P, Lieberman B, Sandau U, Boison D, Mach R, Farwell M: Synthesis and initial characterization of [125I]-5-iodotubercidin, a radioligand for imaging adenosine kinase. J Nucl Med. 58 (Supplement 1): 866,2017.
Mankoff DA, Farwell MD, Clark AS, Pryma DA: Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review. JAMA Oncology. 3 (5): 695-701,2017.
Chen X, Yang Y, Berger I, Khalid U, Patel A, Cai J, Farwell MD, Langer C, Aggarwal C, Albelda SM, Katz SI: Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. Oncotarget. 8 (15): 24213-24223,2017.
Mankoff DA, Farwell MD, Clark AS, Pryma DA: How imaging can impact clinical trial design: molecular imaging as a biomarker for targeted cancer therapy. Cancer J. 21 (3): 218-224,2015.
Farwell MD, Clark AS, Mankoff DA: How imaging biomarkers can inform clinical trials and clinical practice in the era of targeted cancer therapy. JAMA Oncology. 1 (4): 421-422,2015.
Farwell MD, Pryma DA, Mankoff DA: PET/CT imaging in cancer: Current applications and future directions. Cancer. 120 (22): 3433-3445,2014.
Farwell MD, Chong DJ, Iida Y, Bae SA, Easwaramoorthy B, Ichise M: Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide. Ann Nucl Med. 27 (7): 618-624,2013.
Harris PE, Farwell MD, Ichise M: PET quantification of pancreatic VMAT 2 binding using (+) and (-) enantiomers of [18F]FP-DTBZ in baboons. Nucl Med Biol. 60 (4): 60-64,2013.
Hospital of the University of PennsylvaniaDepartment of RadiologyDivision of Nuclear Medicine and Clinical Molecular Imaging3400 Spruce Street