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Michael D. Farwell, MD

Michael D. Farwell, MD Physician

Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

Dr. Farwell is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Radiology

Programs & Centers:

Board Certification:

  • Diagnostic Radiology, 2012
  • Nuclear Medicine, 2013

Clinical Expertise:

  • Angiography
  • Bone Scan
  • CT Scan (Computed Tomography)
  • Diagnostic Imaging
  • Diagnostic Test
  • MRI (Magnetic Resonance Imaging)
  • Nuclear Imaging
  • PET Scan (Positron Emission Tomography)
  • Radioiodine Therapy

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program
  • Vibra Health Plan

Education and Training

Medical School: Columbia University
Residency: Saint Luke's-Roosevelt Hospital Center
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: NewYork-Presbyterian/Columbia University Medical Center

Memberships

ECOG-ACRIN Experimental Imaging Sciences Working Group, National ECOG-ACRIN Immuno-Oncology Working Group (IOWG), National ECOG-ACRIN Melanoma Committee, National Radiological Society of North America (RSNA), International Society of Nuclear Medicine and Molecular Imaging (SNMMI), International World Molecular Imaging Society (WMIS) Publication Committee, International

Hospital Affiliation

Dr. Farwell is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

My research focuses on oncologic applications of molecular imaging, with an emphasis on developing new imaging tools for the rapidly growing field of cancer immunotherapy. I am particularly interested in the development of novel radiotracers / reporter genes for CAR T cell tracking, as well as the development of radiolabeled antibodies for PET imaging of the immune system. To address these research areas, my laboratory utilizes an interdisciplinary team with expertise in a variety of scientific fields, including organic chemistry, radiochemistry, molecular biology, biochemistry, and bioengineering. Many of these translational research projects begin with in vitro studies and animal models, however the goal of every project is clinical application.

Selected Publications:

Huang AC, Orlowski RJ, Xu X, Mick R, George SM, Yan PK, Manne S, Kraya A, Wubbenhorst B, Dorfman L, D’Andrea K, Liu S, Chilukuri L, Kozlov A, Carberry M, Giles L, Kier M, Quagliarello F, McGettigan S, Kreider K, Annamalai L, Zhao A, Mogg R, Xu W, Blumenschein W, Yearley JH, Linette G, Amaravadi RK, Schuchter LM, Nathanson KL, Farwell MD, Karakousis GC, Wherry EJ, Mitchell TC: A Single Dose of Neoadjuvant PD-1 Blockade Predicts Clinical Outcomes in Resectable Melanoma. Nat Med. 25 (3): 454-461,2019.

Sellmyer M, Richman S, Lohith K, Hou C, Lieberman B, Mankoff D, Mach R, Milone M, Farwell M: In vivo monitoring of CAR T cells using [18F]fluoropropyl-trimethoprim. J Nucl Med. 59 (Supplement 1): 122,2018.

Lohith K, Kwon S, Padakanti P, Thanna S, Hou C, Weng CC, Sellmyer M, Mach R, Farwell M: Radiosynthesis and in vitro evaluation of [11C]Shield-1, a PET probe for imaging CAR T cells that express the iCasp9 suicide gene. J Nucl Med. 59 (Supplement 1): 61,2018.

Shah NN, Nagle SJ, Torigian DA, Farwell MD, Hwang WT, Frey N, Nasta SD, Landsburg D, Mato A, June CH, Schuster SJ, Porter DL, Svoboda J: Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor–T-cell therapy in B-cell non-Hodgkin lymphomas. Cytotherapy. 20 (12): 1415-1418,2018.

Gordon MS, Tsai F, Postow M, Hellmann M, Harding JJ, Korn RL, Farwell MD, Mitchell TC, Schuchter LM, Ziolkowska M, O'Donoghue J, Lewis JS, Wu AM, Le W, Wilson I, Weber WA, Wolchok JD, Behera D, Pandit-Taskar N: Imaging of tumor infiltrating T cells with an anti-CD8 minibody 89Zr-IAB22M2C in advanced solid tumors: a phase I first-in-human study. J Immunother Cancer. 6 (Suppl 2): O49,2018.

Maity A, Mick R, Huang AC, George SM, Farwell MD, Lukens JN, Berman AT, Mitchell TC, Bauml J, Schuchter LM, O'Hara M, Lin LL, Demichele A, Christodouleas JP, Haas NB, Patsch DM, Hahn SM, Minn AJ, Wherry EJ, Vonderheide RH: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. Br J Cancer. 119 (10): 1200-1207,2018.

Ahmed HS, Pantel AR, Metz JM, Plastaras JP, Farwell MD: FDG-Avid Focal Liver Reaction From Proton Therapy in a Patient With Primary Esophageal Adenocarcinoma. Clin Nucl Med. 43 (5): e139-e141,2018.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest. 128 (5): 2116-2126,2018.

Lohith K, Kwon S, Padakanti P, Lieberman B, Sandau U, Boison D, Mach R, Farwell M: Synthesis and initial characterization of [125I]-5-iodotubercidin, a radioligand for imaging adenosine kinase. J Nucl Med. 58 (Supplement 1): 866,2017.

Mankoff DA, Farwell MD, Clark AS, Pryma DA: Making Molecular Imaging a Clinical Tool for Precision Oncology: A Review. JAMA Oncology. 3 (5): 695-701,2017.

Chen X, Yang Y, Berger I, Khalid U, Patel A, Cai J, Farwell MD, Langer C, Aggarwal C, Albelda SM, Katz SI: Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. Oncotarget. 8 (15): 24213-24223,2017.

McDonald E, Tchou J, Doot R, Feldman M, Farwell M, Schubert E, Palmer K, Demichele A, Mankoff D, Mach R: Imaging Proliferative Status in Primary Breast Cancer Using the sigma-2 selective ligand, [18]F-ISO-1. J Nucl Med. 57 (Supplement 2): 32,2016.

Mankoff DA, Farwell MD, Clark AS, Pryma DA: How imaging can impact clinical trial design: molecular imaging as a biomarker for targeted cancer therapy. Cancer J. 21 (3): 218-224,2015.

Farwell MD, Clark AS, Mankoff DA: How imaging biomarkers can inform clinical trials and clinical practice in the era of targeted cancer therapy. JAMA Oncology. 1 (4): 421-422,2015.

Farwell MD, Pryma DA, Mankoff DA: PET/CT imaging in cancer: Current applications and future directions. Cancer. 120 (22): 3433-3445,2014.

Farwell MD, Chong DJ, Iida Y, Bae SA, Easwaramoorthy B, Ichise M: Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide. Ann Nucl Med. 27 (7): 618-624,2013.

Harris PE, Farwell MD, Ichise M: PET quantification of pancreatic VMAT 2 binding using (+) and (-) enantiomers of [18F]FP-DTBZ in baboons. Nucl Med Biol. 40 (1): 60-64,2013.

Academic Contact Info

Hospital of the University of Pennsylvania
Department of Radiology
Division of Nuclear Medicine and Clinical Molecular Imaging
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-7750
Patient appointments: 800-789-7366 (PENN)