Find a Doctor or Practice Location

You can also search for providers and practices at Penn Medicine Lancaster General Health or Princeton Health.

I am searching for a
Reset Form
placeholder image: silhouette of male physician

Matthew J. Ziegler, MD Physician

Instructor A of Medicine

Dr. Ziegler is employed by Penn Medicine.

Request a Callback
No Patient Satisfaction Reviews
Why not?

There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients in a medical practice setting.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.

Clinical Specialties


  • Infectious Diseases

Programs & Centers:

Board Certification:

  • Internal Medicine, 2015

Clinical Expertise:

  • AIDS
  • Anal Pap Smear
  • Antiretroviral Salvage Therapy
  • Aspergillosis
  • Bone Infection (Osteomyelitis)
  • C. Difficile (Clostridium Difficile Diarrhea)
  • Cellulitis
  • Encephalitis
  • Fever of Unknown Origin
  • Flu (Influenza)
  • Flu Shot Vaccination
  • Fungal Meningitis
  • Fungemia
  • Genital Warts (Condyloma Acuminatum)
  • Gonorrhea
  • Hepatitis
  • Hepatitis A Vaccination
  • Hepatitis B
  • Hepatitis B Vaccination
  • Hepatitis C
  • Herpes Simplex Virus (HSV)
  • Histoplasmosis
  • HIV and AIDS
  • HPV Vaccination
  • Human Papilloma Virus
  • Japanese Encephalitis Vaccination
  • Joint Infection
  • Lyme Disease
  • Lymphogranuloma Venereum
  • Malaria
  • Measles Vaccination
  • Meningitis
  • Meningitis Vaccination
  • Menningococcal Vaccine
  • MMR Vaccine
  • Mycobacterium
  • Mycobacterium Avium Complex
  • Mycoplasma
  • Mycosis
  • Parasitic Diseases
  • Pneumonia
  • Pneumonia Vaccination
  • Polio Vaccination
  • Pre-Exposure Prophylaxis
  • Prosthetic Joint Infection
  • Pyelonephritis
  • Rabies Vaccination
  • Sexually Transmitted Diseases (STD)
  • Shingles
  • Shingles Vaccination
  • Staph Infection
  • Swollen Lymph Nodes
  • Syphilis
  • Transplant Related Infection
  • Travel Medicine
  • Travel Vaccination
  • Travelers' Diarrhea
  • Tropical Medicine
  • Tuberculosis (TB)
  • Tuberculosis Testing
  • Typhoid Fever Vaccination
  • Viral Encephalitis
  • Viral Meningitis
  • Wound Infection
  • Yellow Fever Vaccination
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Wisconsin
Residency: University of Wisconsin Hospital and Clinics
Fellowship: Hospital of the University of Pennsylvania


Infectious Disease Society of America, National Society for Healthcare Epidemiology of America, National

Hospital Affiliation

Dr. Ziegler is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Healthcare-associated infections in patients with hematologic malignancy.
Transmission of multi-drug resistant organisms within the hospital environment.

Selected Publications:

Ziegler M, Han JH, Landsburg D, Pegues D, Reesey E, Gilmar C, Gorman T, Bink K, Moore A, Kelly BJ: Impact of Levofloxacin for the Prophylaxis of Bloodstream Infection on the Gut Microbiome in Patients With Hematologic Malignancy Open Forum Infect Dis 6 (7): ofz252,2019.

Ziegler M, Landsburg D, Pegues D, Bilker W, Gilmar C, Kucharczuk C, Gorman T, Bink K, Moore A, Fitzpatrick R, Stadtmauer EA, Mangan P, Kraus K, Han JH: Fluoroquinolone Prophylaxis Is Highly Effective for the Prevention of Central Line-Associated Bloodstream Infections in Autologous Stem Cell Transplant Patients Biol Blood Marrow Transplant 25 (5): 1004-1010,2019.

Ziegler M, Freyer C, Landsburg D, Pegues D, Hirsh R, Kucharczuk C, Gilmar C, Gorman T, Palmer M, Harker C, Lightheart E, Han J: Guiding appropriate acid suppression in hematology-oncology units Society for Healthcare Epidemiology of America Annual Meeting : 2019.

Matthew Ziegler MD, MSCE, Craig Freyer PharmD, Daniel Landsburg MD, David Pegues MD, Warren Bilker PhD, Rebecca Hirsh MD, Colleen Kucharczuk DNP, Cheryl Gilmar MS, Theresa Gorman MSN, RN, Melissa Palmer BSN, RN, Christina Harker BSN, RN, Erin Lightheart MBA, Jennifer H. Han, MD, MSCE: Guideline implementation is effective at reducing proton pump inhibitor use in hematology-oncology units; a multidisciplinary intervention for reducing Clostridioides difficile risk Infect Control Hosp Epidemiol : 2019.

Ziegler M, Han J, Landsburg D, Pegues D, Reesey E, Gilmar C, Gorman T, Bink K, Moore A, Kelly B: Impact of levofloxacin for the prophylaxis of bloodstream infection on the gut microbiome in patients with hematologic malignancy Annual IDWeek Meeting Infectious Diseases Society of America, San Francisco, CA : 2018.

Ziegler M, Landsburg D, Pegues D, Alby K, Gilmar C, Bink K, Gorman T, Moore A, Bonhomme B, Omorogbe J, Tango D, Tolomeo P, Han JH: Clinical Characteristics and Outcomes of Hematologic Malignancy Patients With Positive Clostridium difficile Toxin Immunoassay Versus Polymerase Chain Reaction Test Results Infect Control Hosp Epidemiol 39 (7): 863-866,2018.

Ruggero MA, Ziegler MJ, Tebas P, Binkley A, Kelly BJ: Successful treatment of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis with outpatient oritavancin therapy Infect Dis Clin Pract 26 (3): 141-144,2018.

Redwood R, Knobloch MJ, Pellegrini DC, Ziegler MJ, Pulia M, Safdar N: Reducing unnecessary culturing: a systems approach to evaluating urine culture ordering and collection practices among nurses in two acute care settings Antimicrob Resist Infect Control 7 : 4,2018.

Ziegler M, Landsburg D, Pegues D, Alby K, Gilmar C, Bink K, Gorman T, Moore A, Han J: Clinical characteristics and outcomes of hematologic malignancy patients with Clostridium difficile toxin EIA versus PCR positive test results Annual IDWeek Meeting, Infectious Disease Society of America, San Diego, CA : 2017.

Ziegler M, Gilmar C, Landsburg D, Pegues D, Kucharczuk C, Gorman C, Bink C, Moore A, Fitzpatrick R, Stadtmauer E, Mangan P, Kraus K, Han J: Fluoroquinolone prophylaxis for the prevention of central line-associated bloodstream infection in autologous stem cell transplant American Society of Clinical Oncology Annual meeting : 2017.

Academic Contact Info

3 Silverstein Pavilion, 3400 Spruce Street
Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)