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Matthew J. Ziegler, MD Physician

Instructor A of Medicine

Dr. Ziegler is employed by Penn Medicine.

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Clinical Specialties


  • Infectious Diseases

Programs & Centers:

Board Certification:

  • Internal Medicine, 2015

Clinical Expertise:

  • Aspergillosis
  • Bone Infection (Osteomyelitis)
  • C. Difficile (Clostridium Difficile Diarrhea)
  • Cellulitis
  • Flu (Influenza)
  • Flu Shot Vaccination
  • Genital Warts (Condyloma Acuminatum)
  • Hepatitis
  • Hepatitis B
  • Hepatitis C
  • Herpes Simplex Virus (HSV)
  • HIV and AIDS
  • Lyme Disease
  • Malaria
  • Meningitis
  • Mycobacterium
  • Pneumonia
  • Sexually Transmitted Diseases (STD)
  • Shingles
  • Staph Infection
  • Swollen Lymph Nodes
  • Syphilis
  • Travelers' Diarrhea
  • Tuberculosis (TB)
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Wisconsin
Residency: University of Wisconsin Hospital and Clinics
Fellowship: Hospital of the University of Pennsylvania


Infectious Disease Society of America, National Society for Healthcare Epidemiology of America, National

Hospital Affiliation

Dr. Ziegler is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Ziegler M, Landsburg D, Pegues D, Bilker W, Gilmar C, Kucharczuk C, Gorman T, Bink K, Moore A, Fitzpatrick R, Stadtmauer EA, Mangan P, Kraus K, Han JH: Fluoroquinolone Prophylaxis Is Highly Effective for the Prevention of Central Line-Associated Bloodstream Infections in Autologous Stem Cell Transplant Patients Biol Blood Marrow Transplant 25 (5): 1004-1010,2019.

Ziegler M, Han J, Landsburg D, Pegues D, Reesey E, Gilmar C, Gorman T, Bink K, Moore A, Kelly B: Impact of levofloxacin for the prophylaxis of bloodstream infection on the gut microbiome in patients with hematologic malignancy Annual IDWeek Meeting Infectious Diseases Society of America, San Francisco, CA : 2018.

Ziegler M, Landsburg D, Pegues D, Alby K, Gilmar C, Bink K, Gorman T, Moore A, Bonhomme B, Omorogbe J, Tango D, Tolomeo P, Han JH: Clinical Characteristics and Outcomes of Hematologic Malignancy Patients With Positive Clostridium difficile Toxin Immunoassay Versus Polymerase Chain Reaction Test Results Infect Control Hosp Epidemiol 39 (7): 863-866,2018.

Ruggero MA, Ziegler MJ, Tebas P, Binkley A, Kelly BJ: Successful treatment of methicillin-resistant Staphylococcus aureus vertebral osteomyelitis with outpatient oritavancin therapy Infect Dis Clin Pract 26 (3): 141-144,2018.

Redwood R, Knobloch MJ, Pellegrini DC, Ziegler MJ, Pulia M, Safdar N: Reducing unnecessary culturing: a systems approach to evaluating urine culture ordering and collection practices among nurses in two acute care settings Antimicrob Resist Infect Control 7 : 4,2018.

Ziegler M, Landsburg D, Pegues D, Alby K, Gilmar C, Bink K, Gorman T, Moore A, Han J: Clinical characteristics and outcomes of hematologic malignancy patients with Clostridium difficile toxin EIA versus PCR positive test results Annual IDWeek Meeting, Infectious Disease Society of America, San Diego, CA : 2017.

Ziegler M, Gilmar C, Landsburg D, Pegues D, Kucharczuk C, Gorman C, Bink C, Moore A, Fitzpatrick R, Stadtmauer E, Mangan P, Kraus K, Han J: Fluoroquinolone prophylaxis for the prevention of central line-associated bloodstream infection in autologous stem cell transplant American Society of Clinical Oncology (ASCO)Annual Meeting : e19508,2017.

Warrack S, Ziegler M, Duster M, Panjikar P, Safdar N: A pilot randomized trial to determine the tolerability of a probiotic in patients colonized with vancomycin-resistant Enterococcus J Prob Health 4 (2): 142,2016.

Ziegler MJ, Pellegrini DC, Safdar N: Attributable mortality of central line associated bloodstream infection: systematic review and meta-analysis Infection 43 (1): 29-36,2015.

Academic Contact Info

3 Silverstein Pavilion, 3400 Spruce Street
Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)