Pediatric Cardiology
Matthew J. O'Connor, MD
Independent provider
Accepting new patients
Sees newborns through age 18
CHOP Specialty Care, Lancaster

About me

  • Professor of Clinical Pediatrics (Cardiology)

Education and training

  • Medical School: University of Virginia
  • Residency: University of Virginia Children's Hospital
  • Fellowship: Children's Hospital of Philadelphia

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Lancaster General Hospital: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Chester County Hospital: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. O'Connor is an independent physician who is not employed by Penn Medicine Lancaster General Health.

Qualifications and experience

Treatments and Conditions

My research

Hayes EA, Koehl D, Cantor R, Fisher LA, Azeka E, Mokshagundam D, Asante-Korang A, Rusconi P, O'Connor MJ, Nandi D, Kirklin JK, Boyle GJ Long-term survival in children following heart transplantation , Pediatr Transplant, 29: 2025,e70042


Amdani S, Shezad MF, Kroslowitz B, Townsend M, Joong A, Najm H, Marino BS, Rosenthal DN, Lorts A, O'Connor MJ Outcomes for children with congenital heart disease undergoing ventricular assist device implantation: an ACTION registry analysis , J Am Coll Cardiol, 85: 2025,804-814


Edelson JB, Raskin A, Absi M, Adachi I, Aljohani O, Alzubi A, Amdani S, Asante-Korang A, Auerbach S, Bansal N, Bearl D, Boucek K, Butto A, Butts R, Byrnes J, Castleberry C, Conway J, Do N, Dykes J, Friedland-Little J, Greiten L, Henderson H, Hsu D, Jeewa A, Joong A, Khan S, Knoll C, Lantz J, Law S, Lorts A, Maeda K, Martinez H, May L, Mehegan M, Mokshagundam D, Montgomery C, O'Connor M, Parent JJ, Peng DM, Rosenthal DN, Sheybani A, Shezad M, Shugh L, Shwaish N, Spinner J, Su J, Sutcliffe D, Tunuguntla H, VanderPluym C, Vaughn G, Wallis G, Wilkens S, Zinn M, Niebler R; ACTION collaborators The ACTION VAD registry: a collective five-year experience , J Heart Lung Transplant: 2025


Wooster L, O'Connor MJ, Zhang X, Mavroudis CD, Maeda K, Ahmed H, Edwards J, Lin KY, Wittlieb-Weber C, Rossano J, Edelson JB Impact of heart transplant allocation changes on waitlist mortality and clinical practice in pediatric and adult patients with congenital heart disease and cardiomyopathy , Circulation: 2025,epub ahead of print


Chen S, Simpson KE; ACTION Learning Network Investigators Over 100 Fontan patients on systemic ventricular assist device support: an ACTION update , ASAIO J: 2024


Lorts A, VanderPluym C, Adachi I, Perry T, Alexander PMA, Almond CS, Auerbach SR, Barbaro RP, Bhavsar S, Bourque K, Conway J, Danziger-Isakov LA, Davies RR, Eghtesady P, Hirata Y, Ichord RN, Kormos RL, Kroslowitz R, Krucoff M, Lantz J, Mehegan M, Mehran R, Morales DLS, Murray J, Niebler RA, O'Connor MJ, Pagani FD, Peng DM, Rossano JW, Spitzer E, Steiner ME, Sutcliffe DL, Taylor JM, Villa CR, Wearden PD, Rosenthal D ACTION-ARC pediatric and adult congenital heart disease ventricular assist device adverse event definitions - 2023 , ASAIO J, 70: 2024,911-919


Nandi D, Wright LK, Sublett-Smith J, Brax A, Bansal N, Almond CS, Azeka E, Butts R, Chen S, Conway J, Cunningham C, Fisher LA, Hall EK, Hunter T, Kobayashi R, Patterson D, Peng DM, Simpson KE, Ryan TD, Spinner JA, Wisotzkey B, Zangwill S, Gajarski RJ, O'Connor M Suboptimal titration of heart failure medications in pediatric patients: baseline data from ACTION , J Card Fail, 20: 2024,S1071-9164


Bonilla-Ramirez C, Lorts A, Spinner JA, Wright L, Niebler RA, Peng DM, Davies RR, Rosenthal DN, O'Connor MJ Development and validation of a novel pediatric mechanical circulatory support risk stratification tool: the Advanced Cardiac Therapies Improving Outcomes Network (ACTION) ventricular assist device score , ASAIO J: 2024


Kamsheh AM, Bilker WB, Huang YS, Okunowo O, Burstein DS, Edelson JB, Lin KY, Maeda K, Mavroudis CD, O'Connor MJ, Wittlieb-Weber CA, Bogner HR, Rossano JW Prolonged inotrope use after surgery for congenital heart disease: a common occurrence with a high burden of mortality , Pediatr Cardiol: 2024


Shugh SB, Tume SC, Bansal N, Dykes JC, Esch JJ, Jeewa A, Law S, O'Connor M, Parent JJ, Said AS, Scholl FG, Shezad MF, Morray BH; ACTION Investigators Transcatheter axial pump use in pediatric patients on veno-arterial extracorporeal membrane oxygenation: an ACTION collaborative experience , ASAIO J, 70: 2024,602-608