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Matthew Craig Hyman, MD, PHD

Matthew Craig Hyman, MD, PHD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Hyman is employed by Penn Medicine.

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Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2016
  • Internal Medicine, 2014

Clinical Expertise:

  • 3D Electroanatomic Mapping of Arrhythmia Substrates
  • Advanced Cardiac EP Imaging
  • Advanced Catheter Ablation
  • Arrhythmia Management
  • Atrial Fibrillation (Afib)
  • Atrial Fibrillation Ablation
  • Atrial Flutter Ablation
  • Biventricular Device Implantation
  • Bradycardia
  • Cardiac Electrophysiology Study (EPS)
  • Cardiac Resynchronization Therapy (CRT)
  • Complex Arrhythmia
  • Epicardial Ablation
  • Heart Palpitations
  • Heart Rhythms - Slow/Fast
  • Implantable Cardiac Devices
  • Implantable Cardioverter Defibrillator
  • Implantable Loop Recorders (ILR)
  • Inherited Arrhythmia Disease
  • Intracardiac Echocardiography (ICE)
  • Left Atrial Appendage Closure
  • Pacemaker
  • Radiofrequency Ablation (RFA)
  • Sinus Node Dysfunction (SND)
  • Subcutaneous Implantable Cardioverter-Defibrillator (S-ICD)
  • Sudden Cardiac Death SCD
  • Supraventricular Tachycardia (SVT)
  • Ventricular Tachycardia
  • Ventricular Tachycardia Ablation
  • Wolff-Parkinson-White Syndrome

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Hospital Affiliation

Dr. Hyman is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Hyman MC, Vemulapalli S, Szeto WY, Stebbins A, Patel PA, Matsouaka RA, Herrmann HC, Anwaruddin S, Kobayashi T, Desai ND, Vallabhajosyula P, McCarthy FH, Li R, Bavaria JE, Giri J: Conscious Sedation versus General Anesthesia for Transcatheter Aortic Valve Replacement: Insights from the NCDR® STS/ACC TVT Registry. Circulation 136 (22): 2132-2140,2017.

Hyman MC, Gordon JP, Supple GE: How to diagnose and ablate ventricular tachycardia from the papillary muscles. Hands-On Ablation: The Experts' Approach, Second Edition chapter 34 : 335-342,2017.

Hyman MC, Deo R: Proteomics of Atrial Fibrillation: Evolving From a Coarse Understanding to a Fine Phenotype. JAMA Cardiol 2 (5): 474-475,2017.

Liang JJ, Kumareswaran R, Hyman MC, Moore RA, Lin D, Frankel DS: Complications caused by adenosine during catheter ablation of atrial fibrillation. Clin Case Rep. 5 (6): 744-747,2017.

Hyman MC, Ren JF, Anjan VY, Wilensky RL, Frankel DS: Multimodality Imaging to Guide Stenting of an Occluded Pulmonary Vein Following Atrial Fibrillation Ablation. JACC: Clinical Electrophysiology 3 (4): 420-421,2017.

Sutton NR, Hayasaki T, Hyman MC, Anyanwu AC, Liao H, Petrovic-Djergovic D, Badri L, Baek AE, Walker N, Fukase K, Kanthi Y, Visovatti SH, Horste EL, Ray JJ, Goonewardena SN, Pinsky DJ: Ectonucleotidase CD39-driven control of post infarction myocardial repair and rupture. JCI Insight 2 (1): 2017.

Hyman MC, Schaller RD, Epstein AE, Rame JE: Right Ventricular Pacing-Induced Hemodynamic Compromise in a Patient with a Left Ventricular Assist Device. Circ Arrhythm Electrophysiol 9 (11): e004622,2016.

Kanthi Y, Hyman MC, Liao H, Baek AE, Visovatti SH, Sutton NR, Goonewardena SN, Neral MK, Jo H, Pinsky DJ: Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis. J Clin Invest 125 (8): 3027-3036,2015.

Visovatti SH, Hyman MC, Bouis D, Neubig R, McLaughlin VV, Pinsky DJ: Increased CD39 nucleotidase activity on microparticles from patients with idiopathic pulmonary arterial hypertension. PLoS One 7 (7): 2012.

Petrovic-Djergovic D, Hyman MC, Ray JJ, Bouis D, Visovatti SH, Hayasaki T, Pinsky DJ: Tissue-resident ecto-5' nucleotidase (CD73) regulates leukocyte trafficking in the ischemic brain. J Immunol 188 (5): 2387-2398,2012.

Academic Contact Info

9 Founders
3400 Spruce Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)