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Matthew Craig Hyman, MD, PHD

Matthew Craig Hyman, MD, PHD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Hyman is employed by Penn Medicine.

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Clinical Specialties


  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2016
  • Internal Medicine, 2014

Clinical Expertise:

  • Abnormal ECG
  • Alcoholic Cardiomyopathy
  • Amyloidosis
  • Anticoagulation
  • Arrhythmia
  • Arrhythmogenic Right Ventricular Cardiomyopathy
  • Athlete's Heart
  • Atrial Fibrillation (Afib)
  • Atrial Flutter
  • Atrial Tachycardia
  • Atrioventricular Block
  • Bradycardia
  • Cardiac Arrest
  • Cardiac Electrophysiology Study (EPS)
  • Cardiac Risk Assessment
  • Cardiomyopathy
  • Catecholaminergic Polymorphic Ventricular Tachycardia
  • Dilated Cardiomyopathy
  • Electrocardiogram
  • Familial Arrhythmias
  • Familial Cardiomyopathy
  • Family History of Heart Disease
  • First Degree Heart Block
  • Genetic Cardiomyopathy
  • Heart Attack (Myocardial Infarction)
  • Heart Racing
  • Holter Monitor
  • Hypertrophic Cardiomyopathy
  • Implantable Cardiac Monitor Procedure
  • Infiltrative Disorders of the Heart
  • Ischemic Cardiomyopathy
  • Left Atrial Appendage Closure
  • Left Bundle Branch Block
  • Left Heart Failure
  • Loop Recorder
  • Mitral Valve Prolapse
  • Myocarditis
  • Palpitations
  • Paroxysmal Supraventricular Tachycardia
  • Paroxysmal Tachycardia
  • Paroxysmal Ventricular Tachycardia
  • Pre-Excitation Syndrome
  • Premature Beats
  • Premature Ventricular Contractions
  • Right Bundle Branch Block
  • Second Opinion Service
  • Sick Sinus Syndrome
  • Sports Cardiovascular Assessment
  • Supraventricular Tachycardia (SVT)
  • Syncope
  • Tachycardia
  • Tachycardia-Bradycardia Syndrome
  • Type 1 Second-Degree Heart Block
  • Type 2 Second-Degree Heart Block
  • Vasovagal Syncope
  • Ventricular Arrhythmia
  • Ventricular Fibrillation
  • Ventricular Tachycardia
  • Viral Cardiomyopathy
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Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Hospital Affiliation

Dr. Hyman is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

Sutton Nadia R, Bouïs Diane, Mann Kris M, Rashid Imran M, McCubbrey Alexandra L, Hyman Matt C, Goldstein Daniel R, Mei Annie, Pinsky David J: CD73 Promotes Age-Dependent Accretion of Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology : ATVBAHA119313002,2019.

Briceño David F, Liang Jackson J, Shirai Yasuhiro, Markman Timothy M, Enriquez Andres, Lin Aung, Santangeli Pasquale, Riley Michael P, Schaller Robert D, Nazarian Saman, Lin David, Kumareswaram Ramanan, Arkles Jeffery S, Hyman Mathew C, Supple Gregory E, Frankel David S, Garcia Fermin C, Callans David J, Marchlinski Francis E, Dixit Sanjay: Clinical and electrophysiological characteristics of idiopathic ventricular arrhythmias originating from the slow pathway region. Heart rhythm 16 (9): 1421-1428,2019.

Hyman Matthew C, Deo Rajat: Post-cardiac arrest evaluation: understanding non-shockable rhythms. European heart journal : 2019.

Liang Jackson J, Shirai Yasuhiro, Briceño David F, Muser Daniele, Enriquez Andres, Lin Aung, Hyman Matthew C, Kumareswaran Ramanan, Arkles Jeffrey S, Santangeli Pasquale, Schaller Robert D, Supple Gregory E, Frankel David S, Deo Rajat, Epstein Andrew E, Garcia Fermin C, Riley Michael P, Nazarian Saman, Lin David, Callans David J, Marchlinski Francis E, Dixit Sanjay: Electrocardiographic and Electrophysiologic Characteristics of Idiopathic Ventricular Arrhythmias Originating From the Basal Inferoseptal Left Ventricle. JACC. Clinical electrophysiology 5 (7): 833-842,2019.

Kubala Maciej, Lucena-Padros Irene, Xie Shuanglun, Casado-Arroyo Ruben, Frankel David S, Lin David, Santangeli Pasquale, Supple Gregory E, Dixit Sanjay, Tschabrunn Cory M, Liang Jackson J, Yang Jiandu, Hyman Matthew C, Zado Erica S, Marchlinski Francis E: P-wave morphology and multipolar intracardiac atrial activation to facilitate nonpulmonary vein trigger localization. Journal of cardiovascular electrophysiology 30 (6): 865-876,2019.

Mendelson Todd B, Santangeli Pasquale, Frankel David S, Arkles Jeffrey S, Supple Gregory E, Lin David, Riley Michael P, Callans David J, Nazarian Saman, Hyman Matthew C, Kumareswaran Ramanan, Epstein Andrew E, Deo Rajat, Dixit Sanjay, Garcia Fermin C, Zado Erica S, Hutchinson Mathew D, Sadek Mouhannad M, Cooper Joshua M, Marchlinski Francis E, Trerotola Scott O, Schaller Robert D: Feasibility of complex transfemoral electrophysiology procedures in patients with inferior vena cava filters. Heart rhythm 16 (6): 873-878,2019.

Anyanwu Anuli C, Kanthi Yogendra, Fukase Keigo, Liao Hui, Mimura Tekashi, Desch Karl C, Gruca Martin, Kaskar Saabir, Sheikh-Aden Hussein, Chi Liguo, Zhao Raymond, Yadav Vinita, Wakefield Thomas W, Hyman Matthew C, Pinsky David J: Tuning the Thromboinflammatory Response to Venous Flow Interruption by the Ectonucleotidase CD39. Arteriosclerosis, thrombosis, and vascular biology 39 (4): e118-e129,2019.

Hyman Matthew C, Callans David J: Has the Catheter Become Mightier Than the Sword? Circulation. Arrhythmia and electrophysiology 11 (10): e006867,2018.

Hyman Matthew C, Patel Prakash A, Giri Jay: Response by Hyman et al to Letter Regarding Article, "Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement: Insights From the National Cardiovascular Data Registry Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry". Circulation 137 (23): 2545-2546,2018.

Pathak Rajeev K, Fahed Joe, Santangeli Pasquale, Hyman Matthew C, Liang Jackson J, Kubala Maciej, Hayashi Tatsuya, Muser Daniele, Pathak Manina, Kochar Arshneel, Castro Simon A, Garcia Fermin C, Frankel David S, Supple Gregory E, Schaller Robert D, Lin David, Riley Michael P, Deo Rajat, Epstein Andrew E, Zado Erica S, Dixit Sanjay, Callans David J, Marchlinski Francis E: Long-Term Outcome of Catheter Ablation for Treatment of Bundle Branch Re-Entrant Tachycardia. JACC. Clinical electrophysiology 4 (3): 331-338,2018.

Academic Contact Info

9 Founders
3400 Spruce Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)