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Mark H. O'Hara, MD

Mark H. O'Hara, MD Physician

Clinical Professor of Medicine

Dr. O'Hara is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Internal Medicine, 2011
  • Medical Oncology, 2016

Clinical Expertise:

  • Abdominal Chemotherapy
  • Ampullary Mass
  • Anal Cancer
  • Anorectal Cancer
  • Appendix Cancer
  • Biological Targeted Therapy
  • Cancer Chemotherapy
  • Carcinoid of the Stomach
  • Carcinoid Tumor of Pancreas
  • Carcinoid Tumors
  • Chemoradiation
  • Colon Cancer Chemotherapy
  • Colorectal Cancer
  • Cystadenoma of Pancreas
  • Duodenal Mass
  • Esophagogastric Junction Cancer
  • Gallbladder Cancer
  • Gallbladder Mass
  • Gastrointestinal Cancer
  • Hepatobiliary Malignancies
  • Hereditary Colon Cancer
  • Hereditary Nonpolyposis Colorectal Cancer
  • Immunotherapy
  • Insulinoma
  • Malignant Neoplasm of Pancreatic Duct
  • Malignant Rectal Neoplasm
  • Malignant Tumor of Extrahepatic Bile Duct
  • Metastatic Colon Cancer
  • Metastatic Pancreatic Cancer
  • Pancreas Head Cancer
  • Pancreas Tail Cancer
  • Pseudomyxoma Peritonei
  • Recurrent Colorectal Cancer
  • Small Bowel Cancer
  • Small Intestine Cancer
  • Squamous Cell Carcinoma of the Esophagus
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: State University of New York at Stony Brook
Residency: University of Pittsburgh Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American College of Physicians, National American Society of Clinical Oncology, National American Society of Hematology, National Eastern Cooperative Oncology Group, National Parker Center for Cancer Immunotherapy, National

Hospital Affiliation

Dr. O'Hara is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Pancreatic cancer, colorectal cancer, GI cancers, Phase 1, CAR T cell therapy

Selected Publications:

Haas Andrew R, Tanyi Janos L, O'Hara Mark H, Gladney Whitney L, Lacey Simon F, Torigian Drew A, Soulen Michael C, Tian Lifeng, McGarvey Maureen, Nelson Anne Marie, Farabaugh Caitlin S, Moon Edmund, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H, Albelda Steven M, Beatty Gregory L: Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers. Molecular therapy : the journal of the American Society of Gene Therapy : 2019.

Karasic Thomas B, O'Hara Mark H, Loaiza-Bonilla Arturo, Reiss Kim A, Teitelbaum Ursina R, Borazanci Erkut, De Jesus-Acosta Ana, Redlinger Colleen, Burrell Jessica A, Laheru Daniel A, Von Hoff Daniel D, Amaravadi Ravi K, Drebin Jeffrey A, O'Dwyer Peter J: Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial. JAMA oncology 5 (7): 993-998,2019.

Bauman Brittany, Mick Rosemarie, Martinez Eileen, Lawless Theresa M, Zinck Lindsey, Sinclair Paige, Fuhrer Mary, O'Hara Mark, Schneider Charles J, O'Dwyer Peter, Plastaras John, Teitelbaum Ursina, Reiss Kim A: Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial. Journal of the National Comprehensive Cancer Network : JNCCN 17 (4): 358-364,2019.

Lee Jae W, Stone Meredith L, Porrett Paige M, Thomas Stacy K, Komar Chad A, Li Joey H, Delman Devora, Graham Kathleen, Gladney Whitney L, Hua Xia, Black Taylor A, Chien Austin L, Majmundar Krishna S, Thompson Jeffrey C, Yee Stephanie S, O'Hara Mark H, Aggarwal Charu, Xin Dong, Shaked Abraham, Gao Mingming, Liu Dexi, Borad Mitesh J, Ramanathan Ramesh K, Carpenter Erica L, Ji Ailing, de Beer Maria C, de Beer Frederick C, Webb Nancy R, Beatty Gregory L: Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature 567 (7747): 249-252,2019.

Maity Amit, Mick Rosemarie, Huang Alexander C, George Sangeeth M, Farwell Michael D, Lukens John N, Berman Abigail T, Mitchell Tara C, Bauml Josh, Schuchter Lynn M, O'Hara Mark, Lin Lilie L, Demichele Angela, Christodouleas John P, Haas Naomi B, Patsch Dana M, Hahn Stephen M, Minn Andy J, Wherry E John, Vonderheide Robert H: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. British journal of cancer 119 (10): 1200-1207,2018.

Shabason JE, Chen J, Apisarnthanarax S, Damjanov N, Giantonio B, Loaiza-Bonilla A, O'Dwyer PJ, O'Hara M, Reiss KA, Teitelbaum U, Wissel P, Drebin JA, Vollmer C, Kochman M, Mick R, Vergara N, Jhala N, Doucette A, Lukens JN, Plastaras JP, Metz JM, Ben-Josef E.: A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer. Cancer Chemother Pharmacol. 81 (3): 609-614,2018.

Reiss KA, Maxwell KN, Nathanson K, Teitelbaum UR, O’Hara MH, O’Dwyer PJ, Schneider C, Carpenter EL, Mick R, Domcheck SM.: A single arm phase II study of rucapariob maintenance in patients with advanced pancreatic adenocarcinoma and a known deleterious BRCA1, BRCA2 or PALB2 mutation who have achieved stability on platinum therapy. J Clin Oncol 36(4S_suppl), TPS531 : 2018.

Reiss KA, Ben-Josef E, Damjanov N, Hoteit M, O’Hara MH, Karasic TB, Teitelbaum UR, Schneider C, O’Dwyer PJ, Carpenter EL, Mick R, Vonderheide RH.: A pilot study of galunisertib (LY2157299) plus stereotactic body radiotherapy (SBRT) in advanced hepatocellular carcinoma (HCC). J Clin Oncol 36(4S_suppl), TPS528 : 2018.

Karasic TB, O’Hara MH, Teitelbaum UR, Damjanov N, Giantonio BJ, d’Entremont TS, Gallagher M, Zhang PJ, O’Dwyer PJ.: Phase II trial of palbociclib in patients with advanced esophageal or gastric cancer. J Clin Oncol, (4S_suppl), 68 36 : 2018.

Beatty Gregory L, O'Hara Mark H, Lacey Simon F, Torigian Drew A, Nazimuddin Farzana, Chen Fang, Kulikovskaya Irina M, Soulen Michael C, McGarvey Maureen, Nelson Anne Marie, Gladney Whitney L, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H: Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. Gastroenterology 155 (1): 29-32,2018.

Academic Contact Info

Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-306
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 360-0735
Patient appointments: 800-789-7366