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Mark H. O'Hara, MD

Mark H. O'Hara, MD Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. O'Hara is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Internal Medicine, 2011
  • Medical Oncology, 2016

Clinical Expertise:

  • Anal Cancer
  • Bile Duct Cancer (Cholangiocarcinoma)
  • Carcinoid Tumors
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Cancer
  • Gastrointestinal Stromal Tumors (GIST)
  • Liver Cancer
  • Neuroendocrine Tumors
  • Pancreatic Cancer
  • Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
  • Rectal Cancer
  • Small Intestine Cancer
  • Stomach Cancer (Gastric Cancer)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: State University of New York at Stony Brook
Residency: University of Pittsburgh Medical Center
Fellowship: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American College of Physicians, National American Society of Clinical Oncology, National American Society of Hematology, National Eastern Cooperative Oncology Group, National Parker Center for Cancer Immunotherapy, National

Hospital Affiliation

Dr. O'Hara is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Pancreatic cancer, colorectal cancer, GI cancers, Phase 1, CAR T cell therapy

Selected Publications:

Maity Amit, Mick Rosemarie, Huang Alexander C, George Sangeeth M, Farwell Michael D, Lukens John N, Berman Abigail T, Mitchell Tara C, Bauml Josh, Schuchter Lynn M, O'Hara Mark, Lin Lilie L, Demichele Angela, Christodouleas John P, Haas Naomi B, Patsch Dana M, Hahn Stephen M, Minn Andy J, Wherry E John, Vonderheide Robert H: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. British journal of cancer : 2018.

Shabason JE, Chen J, Apisarnthanarax S, Damjanov N, Giantonio B, Loaiza-Bonilla A, O'Dwyer PJ, O'Hara M, Reiss KA, Teitelbaum U, Wissel P, Drebin JA, Vollmer C, Kochman M, Mick R, Vergara N, Jhala N, Doucette A, Lukens JN, Plastaras JP, Metz JM, Ben-Josef E.: A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer. Cancer Chemother Pharmacol. 81 (3): 609-614,2018.

A single arm phase II study of rucapariob maintenance in patients with advanced pancreatic adenocarcinoma and a known deleterious BRCA1, BRCA2 or PALB2 mutation who have achieved stability on platinum therapy.: Reiss KA, Maxwell KN, Nathanson K, Teitelbaum UR, O’Hara MH, O’Dwyer PJ, Schneider C, Carpenter EL, Mick R, Domcheck SM. J Clin Oncol 36(4S_suppl), TPS531 : 2018.

Reiss KA, Ben-Josef E, Damjanov N, Hoteit M, O’Hara MH, Karasic TB, Teitelbaum UR, Schneider C, O’Dwyer PJ, Carpenter EL, Mick R, Vonderheide RH.: A pilot study of galunisertib (LY2157299) plus stereotactic body radiotherapy (SBRT) in advanced hepatocellular carcinoma (HCC). J Clin Oncol 36(4S_suppl), TPS528 : 2018.

Phase II trial of palbociclib in patients with advanced esophageal or gastric cancer.: Karasic TB, O’Hara MH, Teitelbaum UR, Damjanov N, Giantonio BJ, d’Entremont TS, Gallagher M, Zhang PJ, O’Dwyer PJ. J Clin Oncol, (4S_suppl), 68 36 : 2018.

Beatty Gregory L, O'Hara Mark H, Lacey Simon F, Torigian Drew A, Nazimuddin Farzana, Chen Fang, Kulikovskaya Irina M, Soulen Michael C, McGarvey Maureen, Nelson Anne Marie, Gladney Whitney L, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H: Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial. Gastroenterology 155 (1): 29-32,2018.

O’Hara MH, Mick R, Lyman J, Xu J, Hosseini M, LaVallee T, Gherardini PF, Vance B, Trifan O, Dugan U, Shalabi A, Ibrahima R, Vonderheide RH.: A phase Ib/2 study of CD40 agonistic monoclonal antibody (APX005M) together with gemcitabine and nab-paclitaxel with or without nivolumab in untreated metastatic pancreatic adenocarcinoma patients. Society for Immunotherapy of Cancer (SITC), National Harbor, MD : 2017.

Ko J, Bhagwat N, Yee SS, Ortiz N, Sahmoud A, Black T, Aiello NM, McKenzie L, O’Hara M, Redlinger C, Romeo J Carpenter EL, Stanger BZ, Issadore D: Combining machine learning and nanofluidic technology to diagnose pancreatic cancer using exosomes ACS Nano 11 (11): 11182-11193,2017.

Ko J, Bhagwat N, Yee SS, Black T, Redlinger C, Romeo J, O’Hara M, Raj A, Carpenter EL, Stanger BZ, Issadore D: A magenetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis Lab Chip 17 (18): 3086-3096,2017.

O’Hara MH, Stashwick C, Plesa G, Tanyi JL: Overcoming barriers of CAR T cell therapy in patients with mesothelin-expressing cancers Immunotherapy 9 (9): 767-780,2017.

Academic Contact Info

Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-306
3400 Civic Center Blvd

Philadelphia, PA 19104
Phone: (215) 360-0735
Patient appointments: 800-789-7366 (PENN)