Selected Publications
Watanabe K, Gomez AM, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH. PMID: ; PMCID: .: Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma. Blood Adv. 7 (14): 3416-3430,2023 .
Guruprasad P, Carturan A, Zhang Y, Kumashie KG, Cohen IJ, Ghilardi G, Kim KH, Lee JS, Lee Y, Kim JH, Chung J, Shestov M, Pajarillo R, Harris J, Lee YG, Wang M, Ballard H, Gupta A, Ugwuanyi O, Hong SJ, Chen L, Paruzzo L, Kammerman S, Patel RP, Shestova O, Vella L, Schuster SJ, Svoboda J, Porazzi P, Ruella M.: Modulation of the Btla-HVEM Axis to Enhance CAR T Cell Immunotherapy Against Cancer. American Society of Hematology Annual Meeting, San Diego, CA. (768): 2023.
Ghilardi G, Paruzzo L, Svoboda J, Chong Ea, Shestov A, Chen L, Cohen IJ, Gabrielli G, Nasta DS, Porazzi P, Landsburg DJ, Gerson J, Carter J, Barta SK, Yelton R, Pajarillo R, White GW, Ballard H, Weber E, Napier EB, Chong ER, Fraietta JA, Garfall AL, Porter DL, Milone MC, O’Connor R, Schuster SJ, Ruella M.: Bendamustine Is Less Toxic Than Fludarabine-Cyclophosphamide-Based Lymphodepletion before CD28-Costimulated CART19 through Reduced Inflammatory Cytokines. American Society of Hematology Annual Meeting, San Diego, CA. (4483): 2023.
Ruella M, Korell F, Porazzi P, Maus MV. Nat Rev Drug Discov.: Mechanisms of resistance to chimeric antigen receptor-T cells in haematological malignancies. Nat Rev Drug Discovery 22 (12): 976-995,2023.
Yunlin Zhang, Ruchi P. Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Jo, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung Hyun Kim, Ji Hyun Lee, Mathew Angelos, Puneeth Guruprasad, Ivan Cohen, Ositadimma Ugwuanyi, Yong Gu Lee1, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Michael Wang, Soohwan Kim, Sung Min Kim, Hyun Jong Lee, Ji Ho Park, Lei Guang Cui, Tae Bum Lee, In Sik Hwang, Youngha Lee, Yong Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong Hoon Kim, Jong Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella.: Safety and Efficacy of a Novel Anti-CD19 Chimeric Antigen Receptor T Cell Product Targeting a Membrane-Proximal Domain of CD19 with Fast On- and Off-rates against non-Hodgkin Lymphoma: A First-in-Human Study Molecular Cancer 22 (1): 200,2023.
Porazzi P, Isshiki Y, Ghilardi G, Nason S, Yang Z*, Carturan A, Chen L, Zhang Y, Patel R, Guruprasad P, Ugwuanyi O, Cohen IJ, Schuster SJ, Melnick AM, Beguelin W, Ruella M.: Inhibition of EZH2 Improves CART19 Immunotherapy By Reprogramming Lymphoma Tumor Cells and Enhancing T-Cell Functionality. American Society of Hematology Annual Meeting, San Diego, CA. (1018): 2023.
Patel RP, Ghilardi G, Zhang Y, Guruprasad P, Angelos MG, Pajarillo P, Gabunia K, Xu C, Blanchard T, Scholler J, Porazzi P, Linette G, Carreno BM, Ruella M.: Disinhibition of T Cell Activation Via CD5 Knockout Is a Universal Strategy to Enhance Adoptive T Cell Immunotherapies. American Society of Hematology Annual Meeting, San Diego, CA. (102): 2023.
Snook AE, Patel RP, Ghilardi G, Nimmagadda A, Yang S, Qian D, Porazzi P, Mazanet R, Schuster SJ, Barta SK, Vu T, Ruella M, Siciliano NA.: Senza5TM CART5: An Autologous CD5-Deleted Anti-CD5 CART Product with Enhanced Anti-T-Cell Lymphoma Activity. American Society of Hematology Annual Meeting, San Diego, CA. (3462): 2023.
Angelos MG, Patel RP, Chiang YH, Xie W, Pajarillo R, Shaw CE, Singh E, Xu J, Posey AD, Rook A, Rotolo A, Pillai V, Pileri SA, Teachey DT, Ruella M.: Fratricide-Resistant Anti-CD2 Chimeric Antigen Receptor T-Cells with Endogenous CD2 Knockout Are Highly Effective Against T-Cell Neoplasms. American Society of Hematology Annual Meeting, San Diego, CA. (885): 2023.
Cohen IJ, Bochi-Layec AC, Kim KH, Jenks S, Ugwuanyi O, Ghilardi G, Gabrielli G, Harris J, Wang LP, Zhang Y, Pajarillo R, Vlachonikola E, Porazzi P, Sanz I, Ghia P, Stamatopoulos K, Schuster SJ, Ruella M.: Precision Targeting of the Malignant Clone in Diffuse Large B Cell Lymphoma Using Chimeric Antigen Receptor T Cells Against the Clonotypic IGHV4-34 B Cell Receptor. American Society of Hematology Annual Meeting, San Diego, CA. (1020): 2023.
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