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Marco Ruella, MD

Marco Ruella, MD Physician

Scientific Director of the Lymphoma Program Assistant Professor of Pathology and Laboratory Medicine Assistant Professor of Medicine

Languages spoken:

  • Italian

Dr. Ruella is employed by Penn Medicine.

Clinical Specialties


  • Hematology

Programs & Centers:

Clinical Expertise:

  • Acute Lymphocytic Leukemia
  • Acute Myelogenous Leukemia
  • Acute Promyelocytic Leukemia
  • Adult T-Cell Leukemia
  • Adult T-Cell Lymphoma
  • AIDS Related Malignancies
  • Amyloidosis
  • Anaplastic Large Cell Lymphoma
  • Blood Cancer
  • Bone Marrow Biopsy
  • Bone Marrow Failure Syndromes
  • Burkitt Lymphoma
  • Cancer During Pregnancy
  • Castleman Disease
  • Chronic Lymphocytic Leukemia
  • Chronic Myelocytic Leukemia
  • Chronic Myelomonocytic Leukemia
  • CNS Lymphoma
  • Cutaneous Lymphoma
  • Eosinophilic Granuloma
  • Erdheim-Chester Disease
  • Essential Thrombocytosis
  • Graft Versus Host Disease
  • Hairy Cell Leukemia
  • Hematologic Malignancies
  • Histiocytosis
  • HIV Lymphoma
  • HIV Malignancies
  • Hodgkin Lymphoma
  • Intraocular Lymphoma
  • Large Granular Lymphocytic Leukemia
  • Leukemia
  • Light Chain Disorders
  • Marginal Zone Lymphoma
  • Mediastinal Lymphoma
  • Monoclonal Gammopathy of Undetermined Significance
  • Mucosa-Associated Lymphoid Tissue Lymphoma
  • Multiple Myeloma
  • Myelodysplastic Syndromes (MDS)
  • Myeloproliferative Neoplasms (MPN)
  • Non-Hodgkin Lymphoma
  • Pelvic Malignancy During Pregnancy
  • Peripheral T-Cell Lymphoma
  • Plasma Cell Dyscrasia
  • POEMS Syndrome
  • Polycythemia
  • Primary Myelofibrosis
  • Prolymphocytic Leukemia
  • Refractory Anemia With Excess Blasts
  • Sezary Syndrome
  • Transformed Lymphoma
  • Waldenstrom Macroglobulinemia (WM)
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Practice Locations and Appointments

Insurance Accepted

  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid

Education and Training

Medical School:


American Association for Cancer Research, International American Society of Hematology (and Scientific Committee on Transplantation Biology and Cellular Therapies, 2019-2022), International European Hematology Association, International International Society of Cell Therapy, International Italian Lymphoma Foundation, International Society for Immunotherapy of Cancer, International

Hospital Affiliation

Dr. Ruella is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Ruella's laboratory focuses on the mechanisms of relapse after chimeric antigen receptor T cell (CART) immunotherapies with the goal of rationally design innovative combined immunotherapies for relapsing/refractory leukemia and lymphoma.

Dr. Marco Ruella obtained his medical degree with high honors at the University of Torino, Italy, in 2007, and completed his specialization in clinical hematology in 2012. He worked as attending physician at the Hematology and Cell Therapy Division of the Mauriziano Hospital and was Instructor at the Biotechnology School at the University of Torino. From 2012 to 2018 he was post-doctoral fellow and then instructor at the University of Pennsylvania in the Center for Cellular immunotherapies under the mentorship of Drs. Carl June and Saar Gill. From 2017 to 2018 Dr. Ruella served as the Associate Director of Dr. June’s laboratory. In 2018 Dr. Ruella was appointed Assistant Professor in Medicine in the Division of Hematology/Oncology of the Dept. of Medicine of the University of Pennsylvania and Scientific Director of the Lymphoma Program of the Hospital of the University of Pennsylvania.

Dr. Ruella was awarded the inaugural SITC EMD-Serono Cancer Immunotherapy Clinical Fellowship (2014), the AACR-BMS Oncology Fellowship in Clinical Cancer Research (2015), the ASH Scholar Award (2016), a NIH K99-R00 award (2017), the “Paola Campese” Award Leukemia Research (2017) and more recently the Cancer Support Community Award (2018). Dr. Ruella is author of numerous peer-reviewed publications on targeted immunotherapies for hematological cancers and is inventor in several patents on CART therapy.

Selected Publications:

Ghione P, Moskowitz AJ, De Paola NEK, Horwitz SM, Ruella M.: Novel Immunotherapies for T Cell Lymphoma and Leukemia Curr Hematol Malig Rep. : 2018.

Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ.: Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nat Med. 24(10):1499-1503 : 2018.

Ascierto Paolo A, Brugarolas James, Buonaguro Luigi, Butterfield Lisa H, Carbone David, Daniele Bruno, Ferris Robert, Fox Bernard A, Galon Jérôme, Gridelli Cesare, Kaufman Howard L, Klebanoff Christopher A, Melero Ignacio, Nathan Paul, Paulos Chrystal M, Ruella Marco, Sullivan Ryan, Zarour Hassane, Puzanov Igor: Perspectives in immunotherapy: meeting report from the Immunotherapy Bridge (29-30 November, 2017, Naples, Italy). Journal for immunotherapy of cancer 6 (1): 69,2018.

Ruella Marco, June Carl H: Predicting Dangerous Rides in CAR T Cells: Bridging the Gap between Mice and Humans. Molecular therapy : the journal of the American Society of Gene Therapy 26 (6): 1401-1403,2018.

Bu De-Xiu, Singh Reshma, Choi Eugene E, Ruella Marco, Nunez-Cruz Selene, Mansfield Keith G, Bennett Paul, Barton Nathanial, Wu Qilong, Zhang Jiquan, Wang Yongqiang, Wei Lai, Cogan Shawn, Ezell Tucker, Joshi Shree, Latimer Kellie J, Granda Brian, Tschantz William R, Young Regina M, Huet Heather A, Richardson Celeste J, Milone Michael C: Pre-clinical validation of B cell maturation antigen (BCMA) as a target for T cell immunotherapy of multiple myeloma. Oncotarget 9 (40): 25764-25780,2018.

B.A. Chabner and D.L.Longo: Chapter on Adoptive Cell Therapies in the book “Cancer Chemotherapy and Biotherapy” Lippincott Williams and Wilkins, 2018 in preparation : 2018.

Singh N, Shi J, June CH, Ruella M.: Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer. Curr Hematol Malig Rep 12 (6): 522-529,2017.

Ruella M, Maude SL, Engels B, Barrett DM, Frey N, Marcucci K, Shestova O., Singh N., Perazzelli J., Christian DA, Haagen D., Lacey SF, Melenhorst JJ, Brogdon J, Young R, Porter DL, June CH, Grupp SA, and Gill S.: Clinical Efficacy of Anti-CD22 Chimeric Antigen Receptor T Cells for B-Cell Acute Lymphoblastic Leukemia Is Correlated with the Length of the Scfv Linker and Can be Predicted Using Xenograft Models American Society of Hematology Annual Meeting, Atlanta, GA : 2017.

Ruella M, Barrett DM, Shestova O, Perazzelli J, Posey A, Kozlowski M, Lacey SF, Melenhorst JJ, June CH, and Gill S: A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor (CAR19) positive cells. American Society of Hematology Annual Meeting, Atlanta, GA : 2017.

Ruella M, Kenderian SS.: Next-Generation Chimeric Antigen Receptor T-Cell Therapy: Going off the Shelf. BioDrugs 31 (6): 473-481,2017.

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Academic Contact Info

South Tower 8-112
Perelman Center for Advanced Medicine
3400 Civic Center Blvd

Philadelphia, PA 191004
Phone: (215) 746-4880
Patient appointments: 800-789-7366 (PENN)