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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
My clinical expertise is in Molecular Diagnostics.
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
Research in our laboratory is at the intersection of innate immune system and solid tumor biology. Specifically, we study the mononuclear phagocyte system (MPS) with an emphasis on their role in the tumor microenvironment. MPS is part of the innate immune system and comprises of monocytes, macrophages, and dendritic cells (DC). These cells are functionally, phenotypically, and developmentally heterogeneous with many distinct subsets. We are interested in understanding the molecular basis of this developmental and functional heterogeneity within the MPS. A major focus in our laboratory is to understand the role of MPS within the microenvironment of a group of solid tumors known as sarcomas. DCs and macrophages are thought to play important role in cancer by modulating host-immune responses against the tumor cells, promoting metastasis, angiogenesis, etc. Additionally, the ability of these cells to regulate lymphocyte function makes them an important determinant in the success of cancer immunotherapy. Using a combination of advanced genetically engineered mouse models in conjunction with patient-derived samples, we aim to uncover the molecular pathways underlying tumor-MPS interaction with the overarching goal of targeting them for therapeutic purposes.
Briseño CG*, Haldar M*, Kretzer NM, Wu X, Theisen DJ, Kc W, Durai V, Grajales-Reyes GE, Iwata A, Bagadia P, Murphy TL, Murphy KM.: Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells Cell Reports 15 (11): 2462-2474,2016.
Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR.: The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene 35 (38): 5021-5032,2016.
Jeffrey J. Bednarski, Ruchi Pandey, Emily Schulte, Lynn S. White, Bo-Ruei Chen, Gabriel J. Sandoval, Masako Kohyama, Malay Haldar, Andrew Nickless, Amanda Trott, Genhong Cheng, Kenneth M. Murphy, Craig H. Bassing, Jacqueline E. Payton and Barry P. Sleckman: RAG-mediated DNA double strand breaks activate a cell-type-specific
checkpoint to inhibit pre-B cell receptor signals The Journal of Experimental Medicine 213 (2): 209-223,2016.
Grajales-Reyes GE, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, Kretzer NM, Briseño CG, Durai V, Bagadia P, Haldar M, Schönheit J, Rosenbauer F, Murphy TL, Murphy KM.: Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nature Immunology 16 (7): 708-717,2015.
Haldar Malay, Murphy Kenneth M: Origin, development, and homeostasis of tissue-resident macrophages. Immunological reviews 262 (1): 25-35,2014.
Haldar Malay, Kohyama Masako, So Alex Yick-Lun, Kc Wumesh, Wu Xiaodi, Briseño Carlos G, Satpathy Ansuman T, Kretzer Nicole M, Arase Hisashi, Rajasekaran Namakkal S, Wang Li, Egawa Takeshi, Igarashi Kazuhiko, Baltimore David, Murphy Theresa L, Murphy Kenneth M: Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell 156 (6): 1223-34,2014.
Haldar Malay, Randall R Lor, Capecchi Mario R: Synovial sarcoma: from genetics to genetic-based animal modeling. Clinical orthopaedics and related research 466 (9): 2156-67,2008.
Haldar Malay, Karan Goutam, Tvrdik Petr, Capecchi Mario R: Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis. Developmental cell 14 (3): 437-45,2008.
Haldar Malay, Hedberg Matthew L, Hockin Matthew F, Capecchi Mario R: A CreER-based random induction strategy for modeling translocation-associated sarcomas in mice. Cancer research 69 (8): 3657-64,2009.
Haldar Malay, Hancock Jeffrey D, Coffin Cheryl M, Lessnick Stephen L, Capecchi Mario R: A conditional mouse model of synovial sarcoma: insights into a myogenic origin. Cancer cell 11 (4): 375-88,2007.
413 BRB II/III, 421 Curie Blvd