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M. Sean Grady, MD

M. Sean Grady, MD Surgeon

Chairman, Department of Neurosurgery Professor of Otorhinolaryngology: Head and Neck Surgery Charles Harrison Frazier Professor of Neurosurgery

Dr. Grady is employed by Penn Medicine.

About Dr. M. Sean Grady

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Best Doctors in America 2003 - 2018

Recognized annually in Philadelphia magazine's Top Docs issues from 2004 to 2018

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Neurosurgery

Programs & Centers:

Board Certification:

  • Neurological Surgery, 1990

Clinical Expertise:

  • Acoustic Neuroma (Vestibular Schwannoma)
  • Arteriovenous Malformations (AVM)
  • Brain Aneurysm
  • Brain Metastasis
  • Brain Tumors
  • Cancer Surgery
  • Cervical Myelopathy
  • Cranial Base Surgery (Skull Base Surgery)
  • Herniated Disc Pain
  • Lumbar Disc Surgery
  • Meningioma
  • Minimally Invasive Endoscopic Surgery
  • Spinal Cord Cancer
  • Spinal Disc Degeneration

Description of Clinical Expertise

Dr. Grady was appointed the Charles Harrison Frazier Professor & Chairman of the Department of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania in March 1999. He received his undergraduate degree from the University of California, San Diego and medical degree from Georgetown University School of Medicine. He trained in Neurological Surgery at the University of Virginia from 1981-1987 and was a faculty member at the University of Washington from 1987-1999. He is Board Certified by the American Board of Neurological Surgeons and is a fellow of the American College of Surgeons. Dr. Grady served as the Secretary for American Board of Neurological Surgery from 2004-2008, and was appointed Chairman of the ABNS from 2008-2009. Dr. Grady served as a member of the editorial board for the Journal of Neurosurgery from 2000-2010.

Dr. Grady's clinical focus is in the area of Cranial Base Tumors, Pituitary Tumors, Meningiomas, Schwannomas, Malignant Skull Base Tumors as well as Cerebrovascular Disorders, Aneurysms, AVM's. Dr. Grady and Dr. Bert O’Malley (Chairman, Department of Otorhinolaryngology - Head and Neck Surgery) are co-directors of the Cranial Base Center. In addition, Dr. Grady performs general neurosurgery procedures for herniated discs of the back and neck.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Vetrans Choice Program (6/2018 Not Active)

Education and Training

Medical School: Georgetown University School of Medicine
Residency: University of Virginia Health System


ACGME Residency Review Committee for Neurological Surgery, National American Academy of Neurological Surgery, National American Association for the Advancement of Science, National American Association of Neurological Surgeons, National American Board of Neurological Surgery, National American College of Surgeons, National American Medical Association, National Cervical Spine Research Society, National College of Physicians of Philadelphia, Local John Morgan Society, Local Joint Section, Neurotrauma & Critical Care (AANS/CNS), National Joint Section, Spine & Peripheral Nerves (AANS/CNS), National Neurosurgical Society of America, National Neurotrauma Society, National Pennsylvania Medical Society, Local Pennsylvania Neurosurgical Society, Local Philadelphia Neurological Society, Local Society of Neurological Surgeons, National Union League of Philadelphia, Local

Hospital Affiliation

Dr. Grady is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Grady's research interests include memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery.

Selected Publications:

Farquhar DR, Luke K, Worral D, Chiu A, Lee J YK, Grady MS, O'Malley BW, Newman JG, Kennedy D, Palmer J, Adappa N, Khalili SK: Propensity Score Analysis of Endoscopic and Open Approaches to Malignant Paranasal and Skull Base Tumor Outcomes The Laryngoscope : In Press,2015.

Massaro Allie M, Doerfler Sean, Nawalinski Kelsey, Michel Bernard, Driscoll Nicolette, Ju Connie, Patel Hiren, Quattrone Francis, Frangos Suzanne, Maloney-Wilensky Eileen, Sean Grady Michael, Stein Sherman C, Kasner Scott E, Kumar Monisha A: Thromboelastography Defines Late Hypercoagulability After TBI: A Pilot Study. Neurocritical care : 2014.

Xiong Guoxiang, Elkind Jaclynn A, Kundu Suhali, Smith Colin J, Antunes Marcelo B, Tamashiro Edwin, Kofonow Jennifer M, Mitala Christina M, Stein Sherman C, Grady M Sean, Einhorn Eugene, Cohen Noam A, Cohen Akiva S: Traumatic brain injury-induced ependymal ciliary loss decreases cerebral spinal fluid flow. Journal of neurotrauma 31 (16): 1396-404,2014.

Lovatt Ditte, Ruble Brittani K, Lee Jaehee, Dueck Hannah, Kim Tae Kyung, Fisher Stephen, Francis Chantal, Spaethling Jennifer M, Wolf John A, Grady M Sean, Ulyanova Alexandra V, Yeldell Sean B, Griepenburg Julianne C, Buckley Peter T, Kim Junhyong, Sul Jai-Yoon, Dmochowski Ivan J, Eberwine James: Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue. Nature methods 11 (2): 190-6,2014.

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady Sean M: Implementation of a departmental picture archiving and communication system: a productivity and cost analysis. Neurosurgery 73 (3): 528-33,2013.

Ramakrishnan Vijay R, Suh Jeffrey D, Lee Jennifer Y, O'Malley Bert W, Grady M Sean, Palmer James N: Sphenoid sinus anatomy and suprasellar extension of pituitary tumors. Journal of neurosurgery 119 (3): 669-74,2013.

Macyszyn Luke, Lega Brad, Bohman Leif-Erik, Latefi Ahmad, Smith Michelle J, Malhotra Neil R, Welch William, Grady M Sean: Implementation of a Departmental Picture Archiving and Communication System (PACS): A Productivity and Cost Analysis. Neurosurgery : 2013.

Lee John Y K, Barroeta Julieta E, Newman Jason G, Chiu Alexander G, Venneti Sriram, Grady M Sean: Endoscopic endonasal resection of anterior skull base meningiomas and mucosa: implications for resection, reconstruction, and recurrence. Journal of neurological surgery. Part A, Central European neurosurgery 74 (1): 12-7,2013.

Yin Terry, Lindley Timothy E, Albert Gregory W, Ahmed Raheel, Schmeiser Peter B, Grady M Sean, Howard Matthew A, Welsh Michael J: Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injury. PloS one 8 (8): e72379,2013.

Grady MS, Lee J, O'Malley B, Palmer J, Ramakrishnan V: Sphenoid Sinus Anatomy and Suprasellar Extension of Pituitary Tumors. Journal of Neurosurgery : 2013.

Academic Contact Info

HUP - 3 Silverstein
3400 Spruce Street
clinical: 215.662.3483
administrative: 215.349.8325

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)

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