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Lin Z. Li, PhD

Lin Z. Li, PhD Researcher

Research Associate Professor of Radiology

Dr. Li is employed by Penn Medicine.

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American Philosophical Society, International SPIE, International The International Society of Oxygen Transport to Tissue, International

Hospital Affiliation

Dr. Li is employed by Penn Medicine.


Description of Research Expertise:

NMR and optical imaging in cancer and aging

Selected Publications:

Lin Z.J. Li, Rong Zhou, Tuoxiu Zhong, Lily Moon, Eun Ju. Kim, Hui Qiao, M. J. Hendrix, Britton Chance, Jerry D. Glickson: Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Advances in Experimental Medicine and Biology 599 : 67-78,2007.

*Lin Z. Li, *Rong Zhou, He N. Xu, Lily Moon, Tuoxiu Zhong, Eun Ju Kim, Hui Qiao, Dennis Leeper, Britton Chance, Jerry D. Glickson (*Equal contribution): Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential PNAS 106 (16): 6608-6613,2009.

He N. Xu, Julia Tchou, Min Feng, Huaqing Zhao, Lin Z. Li.: Optical redox imaging indices discriminate human breast cancer from normal tissues Journal of Biomedical Optics 21 (11): 114003-1-8,2016.

Sun, N., Xu, H.N., Luo, Q., Li, L.Z.: Potential indexing of the invasiveness of breast cancer cells by mitochondrial redox ratios Adv Exp Med Biol 923 : 121-127,2016.

He N. Xu, Julia Tchou, Lin Z. Li: Redox imaging of human breast cancer core biopsies: a preliminary investigation Academic Radiology 20 (4): 764-768,2013.

He N. Xu, Gang Zheng, Julia Tchou, Shoko Nioka, Lin Z. Li: Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging. SpringerPlus 2 (1): 73 (1-9),2013.

He N. Xu, Shoko Nioka, Jerry D. Glickson, Britton Chance, Lin Z. Li: Quantitative mitochondrial redox imaging of breast cancer metastatic potential Journal of Biomedical Optics 15 (3): 036010(1-10),2010.

He N. Xu, Shoko Nioka, Lin Z. Li: Imaging heterogeneity in the mitochondrial redox state of premalignant pancreas in the pancreas-specific PTEN-null transgenic mouse model Biomarker Research 1 (1): 6(1-11),2013.

Lily Moon, David W. Frederick, Joseph A. Baur, and Lin Z. Li: Imaging redox state in mouse muscles of different ages Adv Exp Med Biol 977 : 51-57,2017.

Lin Z. Li, Nannan Sun: Autofluorescence perspective of cancer diagnostics Natural Biomarkers for Cellular Metabolism: Biology, Techniques, and Applications : 273-297,2014.

Lin Z. Li: Imaging mitochondrial redox potential and its possible link to tumor metastatic potential. J Bioenerg Biomembr 44 (6): 645-653,2012.

Nathan G. Dolloff, Xiahong Ma, David T. Dicker, Robin C. Humphreys, Lin Z. Li and Wafik S. El-Deiry: Spectral imaging-based methods for quantifying autophagy and apoptosis Cancer Biology and Therapy 12 (4): 349-356,2011.

Xiaohong Ma, Shengfu Piao, Dan Wang, Quentin Mcafee, Katherine L. Nathanson, Julian J. Lum, *Lin Z. Li, *Ravi Amaravadi (*Equal contribution): Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma Clinical Cancer Research 17 (10): 3478-3489,2011.

Lin Z. Li, Stephen Kadlececk, He N. Xu, Dania Daye, Benjamin Pullinger, Harrilla Profka, Lewis Chodosh, Rahim Rizi: Ratiometric analysis in hyperpolarized NMR (I): Test of the two-site exchange model and the quantification of reaction rate constants NMR in Biomedicine 26 (10): 1308-20,2013.

Lin Z. Li, He N. Xu, S. Kadlececk, Kavindra Nath, Kejia Cai, Hari Hariharan, Jerry D. Glickson, Rahim Rizi: Non-invasive quantification of intracellular redox state in tissue by hyperpolarized 13C-NMR. Proceedings of the Annual Meeting of the International Society of Magnetic Resonance in Medicine, Melbourne, Australia : 2012.

Lin Z. Li: A pre-tracer approach for improving the accuracy of metabolic measurements by hyperpolarized nuclear magnetic resonance Quant Imaging Med Surg 6 (5): 612-614,2016.

He N. Xu, Stephen Kadlececk, Hoora Shaghaghi, Huaqing Zhao, Harilla Profka, Mehrdad Pourfathi, Rahim Rizi, Lin Z. Li: Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized 13C labeled pyruvate Quantitative Imaging in Medicine and Surgery 6 (1): 57-66,2016.

He N. Xu, Stephen Kadlececk, Harrilla Profka, Jerry D. Glickson, Rahim Rizi, Lin Z. Li: Is higher lactate an indicator of tumor metastatic risk?-A pilot MRS study using hyperpolarized 13C-pyruvate. Academic Radiology 21 (2): 223-231,2014.

Kejia Cai, He N. Xu, Anup Singh, Lily Moon, Mohammad Haris, Ravinder, Reddy, Lin Z. Li: Breast cancer redox heterogeneity detectable with chemical exchange saturation transfer (CEST) MRI Molecular Imaging and Biology 16 (5): 670-9,2014.

Lin Z. Li, Z.Y.J. Wang: Magnetic susceptibility quantitation with MRI by solving boundary value problems Medical Physics 30 (3): 449-453,2003.

Lin Z. Li, John S. Leigh: High-precision mapping of the magnetic field utilizing the harmonic function mean value property Journal of Magnetic Resonance 148 (2): 442-448,2001.

Lin Z. Li: Magnetic susceptibility quantification for arbitrarily shaped objects in inhomogeneous fields Magnetic Resonance in Medicine 46 (5): 907-916,2001.

Lin Z. Li: Averaging of harmonic physical fields over an annular region enclosing field sources American Journal of Physics 70 (10): 1029-1033,2002.

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