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Lawrence B. Holzman, MD

Lawrence B. Holzman, MD Physician

Chief, Renal-Electrolyte and Hypertension
C. Mahlon Kline Professor of Medicine

Dr. Holzman is a Penn Medicine employed physician.

About Dr. Lawrence B. Holzman

Recognized by America's Top Doctors, 2012-14

Recognized by Best Doctors in America 2003. 2011-2016

Recognized by Philadelphia Magazine's annual Top Docs issue,  2015-2016

Clinical Specialties

Specialty:

  • Medicine
    • Renal Electrolyte and Hypertension

Programs & Centers:

Board Certification:

  • Internal Medicine, 1987

Clinical Expertise:

  • Berger's Disease
  • Cryoglobulinemia
  • Diabetic Kidney Diseases
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Glomerular Diseases
  • Glomerulonephritis
  • Glomerulonephritis - Inflammatory
  • Granulomatosis with Polyangiitis
  • Kidney Biopsy
  • Kidney Scleroderma
  • Kidney Vasculitis
  • Lupus Nephritis
  • Membranous Glomerulonephritis (MGN)
  • Microscopic Polyangiitis
  • Nephritis
  • Nephrotic Syndrome
  • Polycystic Kidney Disease
  • Proteinuria
  • Systemic Lupus Erythematosus (SLE)

Description of Clinical Expertise

Glomerular disease
Systemic lupus erythematosis
Systemic vasculitis

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Medicine and Dentistry of New Jersey
Residency: Medical College of Pennsylvania
Fellowship: University of Michigan Medical Center

Memberships

American Association for the Advancement of Science, National American Association of Physicians, National American College of Physicians, National American Heart Association/American Stroke Association, National American Society for Cell Biology, National American Society for Clinical Investigation, National American Society for Microbiology, National American Society of Nephrology, National Chair, Glomerular Disease Advisory Group, American Society of Nephrology, National Chair, Glomerular Disease Advisory Group, American Society of Nephrology, National Kidney Council, American Heart Association, National NIH/NIDDK External Expert Panel, National

Hospital Affiliation

Dr. Holzman is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Holzman is an established and NIH funded laboratory investigator, well recognized for his investigations of mechanisms of cell signaling and also of podocyte biology, where he has contributed importantly to our understanding of the mechanisms that govern podocyte cytoskeletal architecture.

The Holzman lab studies the biochemistry and function of DLK, a member of the mixed lineage kinase family of MAPK kinase kinases. The laboratory initially discovered and cloned DLK and first demonstrated that DLK is a MAP3 kinase capable of activating the mitogen activated protein kinase family of JNK kinases. It showed that DLK is activated by insulin and in soon to be published work demonstrated that deletion of DLK in mice results in a phenotype of resistance to diet induced obesity and cell autonomous increased insulin sensitivity.

Dr. Holzman also investigates the biology of the glomerular podocyte, a unique epithelial cell that appears to play a central role in most forms of glomerular disease. The octopus-like processes of the podocyte interdigitate and form specialized intercellular junctions that function as the kidney glomerular filter. The lab has been a leader in characterizing the molecular components of this intercellular junction and first established evidence to support the hypothesis that these junctional components participate in regulating podocyte morphology by modulating actin cytoskeletal dynamics. The lab has particularly focused on signaling functions of members of the cell adhesion molecules of the Nephrin family and has contributed seminal work on the atypical cadherin FAT1. As part of this work, the lab has developed a transgenic mouse strategy for examining the functional biology of proteins and their interactions specifically in the podocyte that is now used internationally.

Selected Publications:

Spinale Joann M, Mariani Laura H, Kapoor Shiv, Zhang Jidong, Weyant Robert, Song Peter X, Wong Hetty N, Troost Jonathan P, Gadegbeku Crystal A, Gipson Debbie S, Kretzler Matthias, Nihalani Deepak, Holzman Lawrence B: A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease. Kidney international 87 (3): 564-74,2015.

Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PXK, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KEC, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M: Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int 83 (4): 749-56,2013.

George B, Verma R, Soofi AA, Garg P, Zhang J, Park T, Giardino L, Ryzhova L, Johnstone DB, Wong H, Nihalani D, Salant DJ, Hanks SK, Curran T, Rastaldi MP, and Holzman LB: Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mice J Clin Invest 122 (2): 674-92,2012.

Deepak N, Wong H, Verma R, Holzman LB: Src Family Kinases Directly Regulate JIP1 Module Dynamics and Activation Mol Cell Biol 27 (7): 2431-2441,2007.

Verma R, Kovari I, Abdul S, Nihalani D, Patrie K, Holzman LB: Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization J Clin Invest 116 (5): 1346-1359,2006.

Moeller MJ, Soofi A, Sanden S, Floege J, Kriz W, Holzman LB: An efficient system for tissue-specific over-expression of transgenes in podocytes in vivo Am J Physiol Renal Physiol 289 (2): F481-F488,2005.

Moeller MJ, Soofi A, Watzel C, Kriz W, Holzman LB: Protocadherin FAT1 binds Ena/VASP and is necessary for lamellipodial dynamics, cell polarization, and cell migration EMBO J 23 (19): 3769-3779,2004.

Holzman LB, St. John P, Kovari I, Verma R, Holthofer H, Abrahamson D: Nephrin is localized to the slit pore of the glomerular epithelial cell Kidney Intl 56 (4): 1481-1491,1999.

Nihalani D, Meyer D, Pajni S, Holzman LB: Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components EMBO J 20 (13): 3447-3458,2001.

Holzman LB, Merritt S, Fan G: Identification, molecular cloning, and characterization of Dual Leucine Zipper Kinase: a novel serine/threonine kinase that defines a second subfamily of MLK kinases J Biol Chem 269 (49): 30808-30817,1994.

Academic Contact Info

Renal-Electrolyte and Hypertension Division
405 Clinical Research Building
415 Curie Boulevard

Philadelphia, PA 19104-6140
Patient appointments: 800-789-PENN (7366)

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