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Laura M. Dember, MD

Laura M. Dember, MD Physician

Professor of Medicine at the Hospital of the University of Pennsylvania Professor of Epidemiology in Biostatistics and Epidemiology

Dr. Dember is employed by Penn Medicine.

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About Dr. Laura M. Dember

Recognized by America's Top Doctors, 2012-14

Clinical Specialties

Specialty:

  • Renal Electrolyte and Hypertension

Programs & Centers:

Board Certification:

  • Nephrology, 1994

Description of Clinical Expertise

Dr. Dember has more than 20 years of experience as a general nephrologist and has internationally-recognized expertise in the systemic amyloidoses, a group of rare disorders that often affect the kidneys. She has been involved in the development of novel treatments for AL and AA amyloidosis, and is a member of the University of Pennsylvania multidisciplinary amyloidosis program that evaluates and treats patients with all types of amyloidosis and paraprotein disorders.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Yale University School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania
Fellowship: Brigham and Women's Hospital

Memberships

Agency for Healthcare Research and Quality, Department of Health and Human Services, Member, Technical Expert Panel, , Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasia, National American College of Physicians, National American Society of Nephrology, National Australia and New Zealand Society of Nephrology, International Boston Univeristy Department of Medicine Pilot Study Program, Local College of Physicians of Philadelphia, Local Duke NIDDK O'Brien Kidney Center, Member, External Advisory Committee, National FDA-ASN Kidney Health Initiative, Core Committee Member, Clinical Trial Endpoints in Dialysis Vascular Access , National FDA-ASN Kidney Health Initiative, Workgroup Chair, Pragmatic Trials in Nephrology: Challenges and Opportunities, National International Society of Nephrology, International Invited Group Leader, Sex and the Kidneys: Sex Differences in Renal Disease Meeting, National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD July 13-14, 2017, National Kidney Disease: Improving Global Outcomes, Invited Member, Controversies Conference: "Challenges in the Conduct of Clinical Trials in Nephrology Controversies"; Paris, France, International Massachusetts Medical Society, Local Member, Expert Review Panel, National Institute of Diabetes and Digestive and Kidney Diseases, Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study; July 12, 2017, National National Heart, Lung, and Blood Institute, Systolic Pressure Intervention Trial, Member, Measurements, Procedures, and Quality Control Committee, National National Heart, Lung, and Blood Institute, Systolic Pressure Intervention Trial, Member, Morbidity and Mortality Commitee, National National Institutes of Diabetes and Digestive and Kidney Diseases / American Society of Nephrology, Invited Participant, Clinical Trials Task Force Workshop , National National Institutes of Diabetes and Digestive and Kidney Diseases, Central Repository Sample Request Review Panel, National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Data and Safety Monitoring Board, NIDDK Oral versus IV Iron in Chronic Kidney Disease Trial, National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Dialysis Access Consortium Fistula Trial Protocol Committee, National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Forms Committee, Hemodialysis Novel Therapies Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Hemodialysis Fistula Maturation Consortium, Outcomes Committee, National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Quality Control Committee, Dialysis Access Consortium , National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Special Emphasis Panel, Ancillary Studies to ASSESS AKI, National National Institutes of Diabetes and Digestive and Kidney Diseases, Chair, Steering Committee, Time to Reduce Mortality in End-Stage Renal Disease Trial, National National Institutes of Diabetes and Digestive and Kidney Diseases, Hemodialysis Fistula Maturation Consortium, Chair, Quality Control Committee, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Ad-Hoc Review Group, VA-NIDDK Acute Renal Failure Trial, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Central Database Repository Review Group, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Dialysis Access Consortium Steering Committee, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Executive Committee, Hemodialysis Fistula Maturation Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Executive Committee, Hemodialysis Novel Therapies Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Expert Panel, Workshop on Focused Opportunities for Clinical Research in Kidney Disease, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Publications and Ancillary Studies Committee, Dialysis Access Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Publications and Ancillary Studies Committee, Hemodialysis Fistula Maturation Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Safety Committee, Hemodialysis Novel Therapies Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, Ancillary Studies in the Natural History of Acute Kidney Injury, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, Ancillary Studies to Major Ongoing NIDDK Clinical Research Studies, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, Ancillary Studies to NIDDK / NHLBI Clinical Studies, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, CKD Biomarker Discovery and Validation Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, Frequent Dialysis Clinical Trial Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, Frequent Hemodialysis Network Limited Competition Renewal, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, Pilot and Feasibility Clinical Research Grants in Kidney or Urologic Diseases, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Special Emphasis Panel, R01 Conflict Applications, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Steering Committee, Hemodialysis Fistula Maturation Consortium, National National Institutes of Diabetes and Digestive and Kidney Diseases, Member, Steering Committee, Kidney Disease Clinical Studies Initiative and Reviewer, Concept Initiative Grants, National National Institutes of Diabetes and Digestive and Kidney Diseases, Special Emphasis Review Panel, R13 Grants, National National Institutes of Health, Pathogiology of Kidney Disease Study Section, Ad Hoc Member, National National Kidney Foundation of MA, RI, NH and VT, Local National Kidney Foundation, National NIH Health Care Systems Research Collaboratory, Member, Health Care Systems Interactions Working Group, National NIH Office of the Director, Invited participant, "Innovate to Accelerate Meeting: Identifying Research Priorities for the NIH Common Fund", National Veterans Administration, Member, Merit Award Grant Review Panel, National

Hospital Affiliation

Dr. Dember is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Dember conducts patient-oriented research including mechanistic studies and clinical trials in chronic kidney disease and end-stage renal disease (ESRD). She has particular interests in hemodialysis vascular access and interventions to improve clinical outcomes in end-stage renal disease. Her research is funded by the National Institutes of Health. Dr. Dember is Principal Investigator for the Data Coordinating Center of the NIDDK Hemodialysis Novel Therapies Consortium which is conducting early phase clinical trials targeting ESRD-associated inflammation and cardiovascular disease, and she is the Principal Investigator for the "TiME Trial", a large, pragmatic cluster-randomized clinical trial being conducted through the NIH Health Care Systems Research Collaboratory. The TiME Trial has enrolled more than 7200 participants at 266 dialysis units throughout the United States and uses highly centralized implementation and data collection approaches that leverage the infrastructure and clinical care delivery systems of dialysis provider organizations. Dr. Dember is also a principal investigator for the NIDDK Hemodialysis Fistula Maturation Study -- a multicenter observational cohort study designed to elucidate predictors and mechanisms of arteriovenous fistula maturation, and she is a member of the Scientific and Data Coordinating Center for the NIDDK Chronic Renal Insufficiency Cohort Study.

Selected Publications:

Tong Xiaoyong, Hou Xiuyun, Wason Christopher, Kopel Tal, Cohen Richard A, Dember Laura M: Smooth Muscle Nitric Oxide Responsiveness and Clinical Maturation of Hemodialysis Arteriovenous Fistulae. Am J Pathol 187 (9): 2095-2101,2017.

Kopel Tal, Kaufman James S, Hamburg Naomi, Sampalis John S, Vita Joseph A, Dember Laura M: Endothelium-Dependent and -Independent Vascular Function in Advanced Chronic Kidney Disease. Clin J Am Soc Nephrol : 2017.

Alpers CE, Imrey PB, Hudkins KL, Wietecha TA, Radeva M, Allon M, Cheung AK, Dember LM, Roy-Chaudhury P, Shiu Y-T, Terry CM, Farber A, Beck GJ, Feldman HI, Kusek JW, Himmelfarb J.: Histopathology of veins at time of creation of arteriovenous fistulas: findings from the Hemodialysis Fistula Maturation Study J Am Soc Nephrol; doi: 10.1681/ASN.2016050598. [Epub ahead of print] : 2017.

Cheung AK, Imrey PB, Alpers CE, Robbin ML, Radeva M, Larive B, Shiu Y-T, Allon M, Dember LM, Greene T, Himmelfarb J, Roy-Chaudhury PR, Terry CM, Vazquez MA, Kusek JW, Feldman HI: Intimal Hyperplasia, Stenosis, and Arteriovenous Fistula Maturation Failure in the Hemodialysis Fistula Maturation Study J Am Soc Nephrol; doi: 10.1681/ASN.2016121355. [Epub ahead of print] : 2017.

Courtright KR, Madden V, Gabler NB, Cooney E, Kim J, Herbst N, Burgoon L, Whealdon J, Dember LM, Halpern SD: A randomized trial of expanding choice sets to motivate advance directive completion Med Decis Making : 2016 .

Sawinski Deirdre, Lim Mary Ann, Cohen Jordana C, Locke Jayme E, Weiss Brendan, Hogan Jonathan J, Dember Laura M: Patient and Kidney Allograft Survival in Recipients with End Stage Renal Disease from Amyloidosis. Transplantation : 2017.

Dember LM, Archdeacon P, Krishnan M, Lacson E, Ling SM, Roy-Chaudhury P, Smith KA, Flessner MF: Pragmatic Trials in Maintenance Dialysis: Perspectives from the Kidney Health Initiative. J Am Soc Nephrol : 2016.

Dixon BS, Beck GJ, Vazquez MA, Greenberg A, Delmez JA, Allon M, Dember LM, Himmelfarb J, Gassman JJ, Greene T, Radeva MK, Davidson IJ, Ikizler TA, Braden GL, Fenves AZ, Kaufman JS, Cotton JR, Martin KJ, McNei JW, Rahman A, Lawson JH, Whiting JF, Hu B, Meyers CM, Kusek JW, Feldman HI, Dialysis Access Consortium (DAC) Study Group: Effect of dipyridamole plus aspirin on hemodialysis graft patency N Engl J Med 360 : 2191-2201,2009.

Dember LM, Beck GJ, Allon M, Delmez J, Dixon BS, Greenberg A, Himmelfarb J, Vazquez VA, Gassman JJ, Greene T, Radeva MK, Braden GL, Ikizler TA, Rocco MV, Davidson IJ, Kaufman JS, Meyers CM, Kusek JW, Feldman HI. Dialysis Access Consortium (DAC) Study Group: Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized, controlled trial JAMA 299 : 2164-71,2008.

Dember LM, Hawkins PN, Hazenberg BPC, Gorevic PD, Merlini G, Butriemene I, Livneh A, Lesnyak O, puechal X, Lachmann H, Obici L, Balshaw R, Garceau D, Hauck W. Skinner M: Eprodisate for the treatment of renal disease in AA amyloidosis N Engl J Med 356 : 2349-60,2007.

Academic Contact Info

Renal-Electrolyte and Hypertension Division
University of Pennsylvania Perelman School of Medicine
Center for Clinical Epidemiology and Biostatistics
Blockley Hall, Office 920
423 Guardian Drive

Philadelphia, PA 19104
Phone: 215-573-5264
Fax: 215-615-0349
Patient appointments: 800-789-7366 (PENN)