Kyra O'Brien, MD, MSHP
Neurology
Accepting new patients
Sees patients age 18 and up
Penn Memory Center
Schedule onlineCall 215-662-7810
Headshot of Kyra O'Brien, MD, MSHP
Penn Medicine Provider

About me

  • Assistant Professor of Neurology at the Hospital of the University of Pennsylvania

Education and training

  • Medical School: University of Pennsylvania School of Medicine
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

What my patients think about me

Average Rating

292 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
April 2026
very knowledgeable
Anonymous
April 2026
she answered all my questions in an easy to understand manner.
Anonymous
April 2026
provider had a good bedside manner.
Anonymous
March 2026
she is thoughtful, experienced, and quick to see an opportunity to apply these qualities towards her patient's care

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. O'Brien is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Claire Erickson, Kyra S. O'Brien, Emily A. Largent, Kristin Harkins, Cameron Coykendall, Melanie Kleid, Justin T. Clapp, Jason Karlawish Expert consensus on communicating tau PET results to persons living with MCI or dementia: Findings from a modified Delphi study , Alzheimer's & Dementia, 22(4): 2026

Kyra O'Brien, Cameron Coykendall, Kristin Harkins, Xingmei Wang, Abigail Perelman, Megan Zhang, Jason Karlawish Study of the utility and impact of a plasma p-tau181 Alzheimer’s biomarker (SUITABLE) , Alzheimer's & Dementia: Translational Research & Clinical Interventions: 2026

Kyra O’Brien, Sydney Pugh, Cameron Coykendall, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Eric Eaton, and Kevin Johnson WATCH: Warning Assessment and Alerting Tool for Cognitive Health , Poster session presented at the fourth annual a2 National Symposium: 2026

Sydney Pugh, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Kyra O’Brien, Eric Eaton, Kevin Johnson WATCH-SS: A Trustworthy and Explainable Modular Framework for Detecting Cognitive Impairment from Spontaneous Speech , Pacific Symposium on Biocomputing: 2026

Katheryn A Q Cousins, Rory Boyle, Colleen Morse, Anurag Verma, Christopher A Brown, Kyra S O'Brien, Marina Serper, Nadia Dehghani, Penn Medicine BioBank, Corey T McMillan, Edward B Lee, Leslie M Shaw, David A Wolk Electronic Health Records to Test Multimorbidity Influences to Plasma Biomarker Interpretation for Alzheimer's Disease , Annals of Neurology: 2025

Kyra O'Brien and Jason Karlawish Alzheimer’s Disease: New Diagnostic Technologies and Treatments - The Role of Neuroimaging in Diagnosis of Alzheimer Disease , American Geriatrics Society: 2025

Kyra O’Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke Implementation of an Electronic Health Record-Integrated Cognitive Assessment Pathway in Primary Care , Poster session presented at the 2025 Patient-Centered Outcomes Research Institute Annual Meeting, Washington, DC: 2025

Nessen SJ, Chary AN, Bhananker AR, Muir KJ, Southerland LT, O'Brien K, and Friedman AB NOTICE-ED: Nurse or Technician Insights Into Cognitive Evaluations in the Emergency Department , Journal of the American Geriatrics Society , 73(8): 2025,2503-2511

Cameron Coykendall, Megan Zhang, Abigail Perelman, Kristin Harkins, Jason Karlawish, Kyra O'Brien Study of the Utility and Impact of Plasma p-tau181 Alzheimer's Biomarkers - SUIT-ABLE: Patient and Care Partner Outcomes , Poster session presented at the 2025 Association International Conference, Toronto, Canada: 2025

Kyra O'Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke Building a cognitive screening and assessment pathway for primary care: The experience of one health care system , Poster session presented at the 2025 Association International Conference, Toronto, Canada: 2025