Description of Research Expertise
Dementia care delivery, health services research
Selected Publications
Kyra O’Brien MD, Justin Clapp PhD MPH, Shana D. Stites PsyD MS MA, Kristin Harkins MPH, Cameron Coykendall, Melanie Kleid, Jason Karlawish MD, Emily Largent JD PhD RN: Improving hospitalizations and care transitions for people living with dementia: Lessons from the COVID-19 pandemic
Poster session presented at the 2023 Annual Scientific Meeting of the American Geriatrics Society : 2023.
Kyra O’Brien MD, Cameron Coykendall, Melanie Kleid, Kristin Harkins MPH, Nathaniel Chin MD, Justin Clapp PhD, Jason Karlawish MD: Clinician perspectives on the clinical use of plasma Alzheimer’s disease biomarkers Poster session presented at the NIA IMPACT Collaboratory 2023 Scientific Conference on embedded Pragmatic Clinical Trials (ePCTs) in Dementia : 2023.
Emily A Largent, Joshua Grill, Kyra O'Brien, David Wolk, Kristin Harkins, Jason Karlawish: Testing for Alzheimer Disease Biomarkers and Disclosing Results Across the Disease Continuum Neurology : 2023.
O’Brien K, Burke R, and Karlawish, J: A Roadmap for Modifying Clinician Behavior to Improve the Detection of Cognitive Impairment Journal of General Internal Medicine 38 : 508–512,2023.
Kyra O'Brien, Rui Feng, Frederick Sieber, Edward R. Marcantonio, Ann Tierney, Jay Magaziner, Jeffrey L. Carson, Derek Dillane, Daniel I. Sessler, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S. Schwenk, Mitchell Marshall, J. Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A. Hoeft, Jason Karlawish, Samir Mehta, Derek J. Donegan, Annamarie Horan, Susan S. Ellenberg, Mark D. Neuman: Outcomes with spinal versus general anesthesia for patients with and without preoperative cognitive impairment: Secondary analysis of a randomized clinical trial Alzheimer's & Dementia : 2023.
O’Brien KS, Wolk D, Lee E, Das S, Wisse L, De Jager PL, Schneider JA, Bennett DA, McMillan C.: Evidence for a Longevity Genetic Locus Associated with Tau Load in PART Platform. 71st American Academy of Neurology Annual Meeting, Philadelphia, PA : 2019.
McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA: Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Ann Clin Transl Neurol 5 (8): 927-934,2018.
Jefferson-George KS, Wolk DA, Lee EB, McMillan CT: Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimers Dement 13 (9): 1048-1053,2017.
Jefferson-George KS, Lee E, Wolk D, McMillan CT: Cognitive Reserve in Primary Age-Related Tauopathy Poster session presented at Institute on Aging Annual Research Retreat, University of Pennsylvania, Philadelphia, PA : 2016.
Jefferson-George KS, Lee E, Wolk D, McMillan CT: Cognitive Reserve in Primary Age-Related Tauopathy Poster session presented at 68th American Academy of Neurology Annual Meeting, Vancouver, BC, Canada : 2016.
Academic Contact Information
Penn Neuroscience Center - Neurology
3400 Civic Center Blvd
2nd Floor, South Pavilion
Philadelphia,
PA
19104
Patient appointments: 800-789-7366