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Kyong-Mi Chang, MD

Kyong-Mi Chang, MD Researcher

Associate Director, Penn Center for Viral Hepatitis Professor of Medicine

Dr. Chang is employed by Penn Medicine.

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Clinical Specialties


  • Gastroenterology

Programs & Centers:

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Insurance Accepted

  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid

Education and Training

Medical School: Medical College of Pennsylvania
Residency: Saint Francis Hospital and Medical Center-Hartford
Residency: Underwood Memorial Hospital
Residency: Medical College of Pennsylvania
Fellowship: University of California at San Diego Medical Center


AIDS and Related Research Review Group, National American Association for Study of Liver Disease, National American Association for the Study of Liver Disease (AASLD), International American Gastroenterology Association, National American Society for Clinical Investigation, National Digestive Diseases Week (AGA Annual Meeting), National International Coalition to Eliminate HBV (ICE HBV), International International HBV Meeting, International Irish Health Research Board, National National Center for Research Resources, General Clinical Research Center, National NIH GMA2 Member Conflict Study Section Review Committees, NIH Loan Repayment Program (NIAID), National NIH/NIAID Study Section: Microbiology and Infectious Diseases Research Committee (MIDRC), Immunity and Host Defense (IHD) Study Section, National NIH/NIDDK Special Grants Review Committees, National The Million Veteran Program, National VA Merit Review, National VA VISN4 Research Committee, Local VHA Research and Development, National

Hospital Affiliation

Dr. Chang is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Selected Publications:

Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ: Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells Immunity 48 (5) : 1029-1045.e5,2018.

NA Terrault, AS Lok, BJ McMahon, KM Chang, JP Hwang, MM Jonas, RS Brown Jr, NH Bwozej, JB Wong: Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance Hepatology : 2018.

Harris RA, Haberer JE, Musinguzi N, Chang KM, Schechter CB, Doubeni CA, Gross R: Predicting short-term interruptions of antiretroviral therapy from summary adherence data: Development and test of a probability model PLoS One 13 (3): e0194713,2018.

Alter, A, Block TM, Brownstein A, Brosgart C, Chang KM, Chen PJ, Chisari FV, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten T, Gut H, G JT, Yoshida Y, Hu J, Kowdley KV, Li W, Liang TJ, Locarnini S, Lok AS, Mason W, McMahon B, Mehta A, Perrillo R, Revill P, Rice CM, Rinaudo JA, Schinazi R, Seeger C, Shetty K, Tavis J, Zoulim F: A Research Agenda for Curing Chronic Hepatitis B Virus Infection Hepatology 67 (3): 1127-1131,2018.

Bengsch B, Ohtani T, Herati RS, Bovenschene N, Chang KM, Wherry EJ: Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns Journal of Immunological Methods 453 : 3-10,2018.

Klarin D, Damrauer SM, Cho K, Sun YV, Teslovich TM, Honerlaw J, Gagnon DR, DuVall SL, Li Jin, Peloso, Chaffin M, Small AM, Huang J, Tang H, Lynch J, Ho YL, Liu D, Emdin CA, Li AH, Huffman J, Lee JS, Natarajan P, Chowdhury R, Saleheen D, Vujkovic M, Baras A, Pyarajan S, Di Angelantonio E, Neale BM, Naheed A, Khera AV, Danesh J, Chang KM, Abecasis G, Willer C, Dewey FE, Carey DJ, MIGen Consortium, The Geisinger-Regeneron DiscovEHR Collaboration, The VA Million Veteran Program, Concato J, Gaziano JM, Tsao PS: Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program Nature Genetics : 2018.

Block TM, Alter H, Brown N, Brownstein A, Brosgart C, Chang KM, Chen PJ, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten TF, Guo JT, Hoshida Y, Kowdley KV, Li W, Lok AS, McMahon B, Mehta A, Perrillo R, Rice CM, Rinaudo J, Schinazi RF, Shetty K.: Research priorities for the discovery of a cure for chronic hepatitis B: Report of a workshop Antiviral Research 150 : 93-100,2017.

Gowda C, Sheikh U, Maier A, Chang KM, Kaplan DE, LoRe V, Amorosa VK: Identifying barriers and potential strategies to improve HCC surveillance for HBV-infected Veterans Federal Practitioner 34 : S20-S29,2017.

Ojiro K, Qu X, Cho HS, Park J, Vuidepot A, Lissin N, Molloy PE, Bennett A, Jakobsen BK, Kaplan DE, Riley JL, Chang KM: Modulation of HCV-specific CD8 effector T-cell function with antiviral effect in infectious hepatitis C virus co-culture model Journal of Virology 91 (10): e02129-16,2017.

Klarin D, Small A, Huang J, Lynch J, Arya S, Assimes T, Natarajan P, Saleheen D, Kathiresan S, Rader DJ, Concato J, Gaziano M, Cho K, Wilson P, Chang KM, O'Donnel C, Tsao P and Damrauer SM on behalf of the VA Million Veteran Program: Genetic evidence suggests a significant overlap in the pathogenesis of peripheral artery and coronary artery disease Society for Vascular Surgery Vascular Research Initiative Conference : 2017.

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Academic Contact Info

Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue

Philadelphia, PA 19104
Phone: (215) 823-5893