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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with particularly focus in human hepatitis C and B viruses, +/- HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also examining the genetic basis of cardio metabolic disorders using big data involving clinical and genetic data. Since 2020, Dr. Chang has actively engaged in research involving COVID-19 given her expertise in clinical research as well as virology/immune pathogenesis.
Small AM, Huffman JE, Klarin D, Sabater-Lleal M, Lynch JA, Assimes TL, Sun YV, Miller D, Freiberg MS, Morrison AC, Rader DJ, Wilson PWF, Cho K, Tsao PS, Chang KM, Smith NL, O'Donnell CJ, de Vries PS, Damrauer SM; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Hemostasis Working Group and the VA Million Veteran Program.: Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report Arterioscler Thromb Vasc Biol 41 (1) : 380-386,2021.
Thom CS, Ding Z, Levin MG, Damrauer SM, Lee KM, Lynch J, Chang KM, Tsao PS, Cho K, Wilson PWF, Assimes TL, Sun YV, O'Donnell CJ, VA Million Veteran Program, Vujkovic M, Voight BF: Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes but not coronary artery disease Hum Mol. Genet 29 (19): 2020.
Small A, Huffman J, Klarin D, Lynch JA, Assimes T, Duvall S, Sun Y, Shere L, Natarajan P, Gaziano M, Rader D, Wilson P, Tsao P, Chang KM, Cho K, O'Donnell C, Casas J, Damrauer S: PCSK9 loss of function is protective against extra-coronary atherosclerotic
cardiovascular disease in a large multi-ethnic cohort PLOS One : 2020.
D Klarin, S Verma, R Judy, O Dikilitas, B Wolford, I Paranjpe, M Levin, C Pan, C Tcheandjieu, J Spin, J Lynch, T Assimes, L Nyronning, E Mattsson, T Edwards, J Denny, E Larson, MT Lee, D Carrell, Y Zhang, GJarvik, A Gharavi, J Harley, F Mentch, J Pacheco, H Hakonarson, A Skogholt, L Thomas, M Gabrielsen, K Hveem, J Nielsen, W Zhou, L Fritsche, J Huang, P Natarajan, Y Sun, S DuVall, D Rader, K Cho, KM Chang, P Wilson, C O'Donnell, S Kathiresan, S Scali, S Berceli, C Willer, G Jones, M Bown, G Nadkarni, I Kullo, M Ritchie, S Damrauer, and P Tsao: Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program Circulation 142 (17): 2020.
KE Johnson, KM Siewert, D Klarin, SM Damrauer, the VA Million Veteran Program, KM Chang, PS Tsao, TL Assimes, KN Maxwell, BF Voight: The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study PLOS Medicine : 2020.
M Serper, M Vujkovic, DE Kaplan, R Carr, KM Lee, Q Shao, DM Miller, PD Reaven, LS Phillips, CJ O'Donnell, JB Meigs, PWF Wilson, R Vickers-Smith, HR Kranzler, AC Justice, JM Gaziano, S Muralidhar, S Pyarajan, SL DuVall, TL Assimes, JS Lee, PS Tsao, DJ Rader, SM Damrauer, JA Lynch, D Saleheen, BF Voight, KM Chang: Validating a Non-Invasive, ALT-Based Non-Alcoholic Fatty Liver Phenotype in the Million Veteran Program PLOS ONE : 2020.
KJ Wangensgeen and KM Chang: Multiple roles for hepatitis B and C viruses and the host in the development of hepatocellular carcinoma Hepatology : 2020.
Lau DTY, Ganova-Raeva L, Wang J, Mogul D, Chung RT, Lister-Melman M, Chang KM, Shaikh OS, Janssen HLA, Wahed AS, Lok AS, Hepatitis B Research Network: Precore and basal core promoter hepatitis B virus (HBV) variants are present from a young age and differ across HBV genotypes Hepatology : 2020.
M Vujkovic, JM Keaton, JA Lynch, DR Miller, J Zhou, C Tcheandjieu, JE Huffman, TL Assimes, K Lorenz, X Zhu, AT Hilliard, RL Judy, J Juang, KM Lee, D Klarin, S Pyarajan, J Danesh, O Melander, A Rasheed, NH Mallick, SS Sheikh, S Hameed, IH Qureshi, MH Afzal, U Malik, A Jalal, S Abbas, X Sheng, L Gao, KH Kaestner, K Susztak, YV Sun, SL Duvall, K Cho, JS Lee, JM Gaziano, LS Philips, JB Meigs, PD Reaven, PW Wilson, TL Edwards, DJ Rader, SM Damrauer, CJ O'Donnell, PS Tsao, HPAP Consortium, Regeneron Genetics Center, VA Million Veteran Program, KM Chang*, BF Voight* and D Saleheen*: Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis Nature Genetics 52 (7) : 680-691,2020.
Siewert KM, Klarin D, Damrauer SM, Chang KM, Tsao PS, Assimes TL, Davey Smith G, Voight BF: Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache Int J Epidemiol 49 (3): 1022-1031,2020.
Corporal Michael J. Crescenz VA Medical CenterMedical Research Building A4243900 Woodland Avenue