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Kyong-Mi Chang, MD Researcher

Associate Director, Penn Center for Viral Hepatitis Professor of Medicine

Dr. Chang is employed by Penn Medicine.

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Clinical Specialties

Programs & Centers:

Insurance Accepted

  • OPR Medicare
  • OPR New Jersey Medicaid
  • OPR Pennsylvania Medicaid

Education and Training

Medical School: Medical College of Pennsylvania
Residency: Saint Francis Hospital and Medical Center-Hartford
Residency: Underwood Memorial Hospital
Fellowship: University of California at San Diego Medical Center


AIDS and Related Research Review Group, National American Association for Study of Liver Disease, National American Association for the Study of Liver Disease (AASLD), National American Gastroenterology Association, National American Society for Clinical Investigation, National Digestive Diseases Week (AGA Annual Meeting), National International Coalition to Eliminate HBV (ICE HBV), International International HBV Meeting, International Irish Health Research Board, International National Center for Research Resources, General Clinical Research Center, National NIH GMA2 Member Conflict Study Section Review Committees, NIH Loan Repayment Program (NIAID), National NIH/NIDDK Special Grants Review Committees, National VA Office of R&D, National VA Office of R&D, National VA VISN4 Research Committee, Local

Hospital Affiliation

Dr. Chang is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Chang's research expertise is in immune mechanisms of viral persistence and liver disease pathogenesis in human hepatitis C and B viruses, with and without HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also exploring genetic and clinical databases to better understand and improve human health.

Selected Publications:

H Fang, Q Hui, J Lynch, J Honerlaw, TL Assime, J Huang, M Vujovic, SM Damrauer, S Pyarajan, JM Gaziano, SL DuVall, CJ O’Donnell, K Cho, KM Chang, PWF Wilson, PS Tsao, the VA Million Veteran Program, YV Sun* and H Tang*: Harmonizing genetic ancestry and self-identified race/ethnicity in genome-wide association studies The American Journal of Human Genetics 105 : 1-10,2019.

Bick AG, Akwo E, Robinson-Cohen C, Lee K, Lynch J, Assimes TL, DuVall S, Edwards T, Fang H, Freiberg SM, Giri A, Huffman JE, Huang J, Hull L, Kember RL, Klarin D, Lee JS, Levin M, Miller DR, Natarajan P, Saleheen D, Shao Q, Sun YV, Tang H, Wilson O, Chang KM, Cho K, Concato J, Gaziano JM, Kathiresan S, O'Donnell CJ, Rader DJ, Tsao PS, Wilson PW, Hung AM, Damrauer SM; VA Million Veteran Program.: Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program Circulation : 2019.

Klarin D, Lynch J, Aragam K, Chaffin M, Assimes TL, Huang J, Lee KM, Shao Q, Huffman JE, Natarajan P, Arya S, Small A, Sun YV, Vujkov M, Freiberg MS, Wang L, Chen J, Saleheen D, Lee JS, Miller DR, REaven P, Alba, PR, Patterson OV, DuVall SL, Boden WE, Beckman JA, Gaziano JM, Concato J, Rader DJ, Cho K, Chang KM, Wilson PWF, O’Donnell CJ, Kathiresan S, VA Million Veteran Program, Tsao PS, Damrauer SM: Genome-wide association study of peripheral artery disease in the Million Veteran Program Nature Medicine (In Press) : 2019.

Kyong-Mi Chang, Daniel Traum, Jang-June Park, Suzanne Ho, Keisuke Ojiro, David K. Wong, Abdus S. Wahed, Norah Terrault, Mandana Khalili, Richard K. Sterling, Harry L.A. Janssen, Margaret C. Shuhart, Daryl T. Lau, Lewis R. Roberts, Geoffrey S. Johnson, David E. Kaplan, Michael R. Betts, William M. Lee, and Anna S. F. Lok for the Hepatitis B Research Network (HBRN): Distinct phenotype and function of circulating V-delta 1+ and v-delta 2+ gammadelta T-cells in acute and chronic hepatitis B PLoS Pathogens 15 (4): e1007715,2019.

Wang YJ, Traum D, Schug J, Gao L, Liu C, HPAP Consortium, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH: Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes Cell Metabolism 29 (3): 769-783,2019.

Klarin D, Damrauer SM, Cho K, Sun YV, Teslovich TM, Honerlaw J, Gagnon DR, DuVall SL, Li Jin, Peloso, Chaffin M, Small AM, Huang J, Tang H, Lynch J, Ho YL, Liu D, Emdin CA, Li AH, Huffman J, Lee JS, Natarajan P, Chowdhury R, Saleheen D, Vujkovic M, Baras A, Pyarajan S, Di Angelantonio E, Neale BM, Naheed A, Khera AV, Danesh J, Chang KM, Abecasis G, Willer C, Dewey FE, Carey DJ, MIGen Consortium, The Geisinger-Regeneron DiscovEHR Collaboration, The VA Million Veteran Program, Concato J, Gaziano JM, Tsao PS: Genetics of Blood Lipids Among ~300,000 Multi-Ethnic Participants of the Million Veteran Program Nature Genetics 50 (11): 1514-1523,2018.

Bengsch B, Ohtani T, Khan O, Setty M, Manne S, O'Brien S, Gherardini PF, Herati RS, Huang AC, Chang KM, Newell EW, Bovenschen N, Pe'er D, Albelda SM, Wherry EJ: Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells Immunity 48 (5) : 1029-1045.e5,2018.

NA Terrault, AS Lok, BJ McMahon, KM Chang, JP Hwang, MM Jonas, RS Brown Jr, NH Bwozej, JB Wong: Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance Hepatology : 2018.

Alter, A, Block TM, Brownstein A, Brosgart C, Chang KM, Chen PJ, Chisari FV, Cohen C, El-Serag H, Feld J, Gish R, Glenn J, Greten T, Gut H, G JT, Yoshida Y, Hu J, Kowdley KV, Li W, Liang TJ, Locarnini S, Lok AS, Mason W, McMahon B, Mehta A, Perrillo R, Revill P, Rice CM, Rinaudo JA, Schinazi R, Seeger C, Shetty K, Tavis J, Zoulim F: A Research Agenda for Curing Chronic Hepatitis B Virus Infection Hepatology 67 (3): 1127-1131,2018.

Harris RA, Haberer JE, Musinguzi N, Chang KM, Schechter CB, Doubeni CA, Gross R: Predicting short-term interruptions of antiretroviral therapy from summary adherence data: Development and test of a probability model PLoS One 13 (3): e0194713,2018.

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Academic Contact Info

Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue

Philadelphia, PA 19104
Phone: (215) 823-5893