Description of Research Expertise

Dr. Shindler's research is examining potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.

Keywords
Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision

Selected Publications

McDougald DS, Dine KE, Zezulin AU, Bennett J, Shindler KS: SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis Invest. Ophthalmol. Vis. Sci. 59 : 1212-1220,2018.

Grinblat GA, Khan RS, Dine K, Wessel H, Brown L, Shindler KS: RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome Invest. Ophthalmol. Vis. Sci. 59 : 2470-2477,2018.

Khan RS, Dine K, Bauman B, Lorentsen M, Lin L, Brown H, Hanson LR, Svitak AL, Wessel H, Brown L, Shindler KS: Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model Sci. Rep. 7 : 41768,2017.

Khan RS, Dine K, Das Sarma J, Shindler KS: SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease Acta Neuropathol. Commun. 2 (1): 3,2014.

Zuo L, Khan RS, Lee V, Dine K, Wu W, Shindler KS: SIRT1 promotes RGC survival and delays loss of function following optic nerve crush Invest. Ophthalmol. Vis. Sci. 54 (7): 5097-102,2013.

Chen Y, Khan RS, Cwanger A, Song Y, Steenstra C, Bang S, Cheah JH, Dunaief J, Shindler KS, Snyder SH, Kim SF: Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity J. Neurosci. 33 (8): 3582-7,2013.

Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS: Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis Front. Neurol. 3 : 84,2012.

Shindler KS, Chatterjee D, Biswas K, Goyal A, Dutt M, Nassrallah M, Khan RS, Das Sarma J: Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus J. Neuropathol. Exp. Neurol. 70 (6): 470-80,2011.

Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A: Oral resveratrol reduces neuronal damage in a model of multiple sclerosis J. of Neuro-Ophthalmol. 30 (4): 328-39,2010.

Das Sarma J, Kenyon LC, Hingley ST, Shindler KS: Mechanisms of primary axonal damage in a viral model of multiple sclerosis J. Neurosci. 29 (33): 10272-10280,2009.

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Academic Contact Information

Scheie Eye Institute
51 North 39th Street
Philadelphia, PA 19104
Patient appointments: 800-789-7366