Description of Research Expertise:
Dr. Shindler's research is examing potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.
Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision
Khan RS, Dine K, Das Sarma J: SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
Acta Neuropathol. Commun. 2 (1): 3,2014.
Zuo L, Khan RS, Lee V, Dine K, Wu W: SIRT1 promotes RGC survival and delays loss of function following optic nerve crush Invest. Ophthalmol. Vis. Sci. 54 (7): 5097-102,2013.
Chen Y, Khan RS, Cwanger A, Song Y, Steenstra C, Bang S, Cheah JH, Dunaief J, Shindler KS, Snyder SH: Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity
J. Neurosci. 33 (8): 3582-7,2013.
Khan RS, Fonseca-Kelly Z, Callinan C, Zuo L, Sachdeva MM: SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells Front. Cell. Neurosci. 6 : 63,2012.
Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K,Dutt M: Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis Front. Neurol. 3 : 84,2012.
Quinn T, Dutt M: Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis Front. Neurol. 2 : 50,2011.
Shindler KS, Chatterjee D, Biswas K, GoyalA, DuttM, Nassrallah M, Khan RS: Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus J. Neuropathol. Exp. Neurol. 70 (6): 470-80,2011.
Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC: Oral resveratrol reduces neuronal damage in a model of multiple sclerosis J. of Neuro-Ophthalmol. 30 (4): 328-39,2010.
Das Sarma J, Kenyon LC, Hingley ST: Mechanisms of primary axonal damage in a viral model of multiple sclerosis J. Neurosci. 29 (33): 10272-10280,2009.
Shindler KS, Ventura E, Rex, TS, Elliott P: SIRT1 activation confers neuroprotection in experimental optic neuritis Invest. Ophthalmol. Vis. Sci. 48 (8): 3602-3609,2007.
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