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Kenneth S. Shindler, MD, PhD

Kenneth S. Shindler, MD, PhD Physician

Associate Professor of Neurology Associate Professor of Ophthalmology

Dr. Shindler is employed by Penn Medicine.

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Clinical Specialties


  • Ophthalmology

Programs & Centers:

Board Certification:

  • Ophthalmology, 2005

Description of Clinical Expertise

Neuro-ophthalmology. Dr. Shindler treats patients with neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Superior Vision Benefit Mgmt, Inc (Block Vision)
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Washington University
Residency: Penn Presbyterian Medical Center
Residency: Scheie Eye Institute
Fellowship: Scheie Eye Institute


American Academy of Ophthalmology, National American Board of Ophthalmology, National Association for Research in Vision and Ophthalmology, International North American Neuro-Ophthalmology Society, International Pennsylvania Academy of Ophthalmology, Local Research to Prevent Blindness, National Society for Neuroscience, International Society of Heed Fellows, National

Hospital Affiliation

Dr. Shindler is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Shindler's research is examing potential mechanisms to provide neuroprotection of retinal ganglion cells in optic neuritis. Optic neuritis is an inflammatory disease of the optic nerve that often occurs as part of the neurodegenerative disease multiple sclerosis. Damage to nerve cells can lead to permanent vision loss in these patients. Dr. Shindler's studies are helping to identify new therapies to prevent nerve damage in this disease, and such therapies will also likely have benefits for other neurodegenerative diseases as well.

Neuro-ophthalmologic conditions, including optic neuropathies, papilledema, and binocular double vision

Selected Publications:

Khan RS, Dine K, Das Sarma J: SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease Acta Neuropathol. Commun. 2 (1): 3,2014.

Zuo L, Khan RS, Lee V, Dine K, Wu W: SIRT1 promotes RGC survival and delays loss of function following optic nerve crush Invest. Ophthalmol. Vis. Sci. 54 (7): 5097-102,2013.

Chen Y, Khan RS, Cwanger A, Song Y, Steenstra C, Bang S, Cheah JH, Dunaief J, Shindler KS, Snyder SH: Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity J. Neurosci. 33 (8): 3582-7,2013.

Khan RS, Fonseca-Kelly Z, Callinan C, Zuo L, Sachdeva MM: SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells Front. Cell. Neurosci. 6 : 63,2012.

Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K,Dutt M: Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis Front. Neurol. 3 : 84,2012.

Quinn T, Dutt M: Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis Front. Neurol. 2 : 50,2011.

Shindler KS, Chatterjee D, Biswas K, GoyalA, DuttM, Nassrallah M, Khan RS: Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus J. Neuropathol. Exp. Neurol. 70 (6): 470-80,2011.

Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC: Oral resveratrol reduces neuronal damage in a model of multiple sclerosis J. of Neuro-Ophthalmol. 30 (4): 328-39,2010.

Das Sarma J, Kenyon LC, Hingley ST: Mechanisms of primary axonal damage in a viral model of multiple sclerosis J. Neurosci. 29 (33): 10272-10280,2009.

Shindler KS, Ventura E, Rex, TS, Elliott P: SIRT1 activation confers neuroprotection in experimental optic neuritis Invest. Ophthalmol. Vis. Sci. 48 (8): 3602-3609,2007.

View all publications

Academic Contact Info

Scheie Eye Institute
51 North 39th Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)

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