Penn Medicine Provider
Cardiology
Kenneth B. Margulies, MD
he/his
5.0
(143)
Accepting new patients
Sees patients age 18 and up
Penn Heart and Vascular Center

About me

  • Research Director, Heart Failure/Transplantation
  • Director, Cardiology Clinical Research Unit
  • Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
  • Professor of Medicine in Physiology

I am a physician-scientist with a clinical practice focused on Advanced Heart Failure and Transplant Cardiology and Inherited Cardiomyopathies.

Recognized by America's Top Doctors 2015 - 2023

Recognized in Philadelphia magazine's annual Top Docs issues from 2017 - 2023

Education and training

  • Medical School: Jefferson Medical College
  • Residency: Mayo Clinic
  • Fellowship: Mayo Clinic

What my patients think about me

Average Rating
5.0

143 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

April 2025
5.0
5.0
excellent physician
April 2025
5.0
5.0
very thorough and very knowledgeable
April 2025
5.0
5.0
great guy makes u feel better
March 2025
5.0
5.0
he took responsibility for contacting the pacemaker/defibrillator doctor to coordinate my treatment

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Margulies is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Zheng SL, Henry A, Cannie D, Lee M, Miller D, McGurk KA, Bond I, Xu X, Issa H, Francis C, De Marvao A, Theotokis PI, Buchan RJ, Speed D, Abner E, Adams L, Aragam KG, Ärnlöv J, Raja AA, Backman JD, Baksi J, Barton PJR, Biddinger KJ, Boersma E, Brandimarto J, Brunak S, Bundgaard H, Carey DJ, Charron P, Cook JP, Cook SA, Denaxas S, Deleuze JF, Doney AS, Elliott P, Erikstrup C, Esko T, Farber-Eger EH, Finan C, Garnier S, Ghouse J, Giedraitis V, Guðbjartsson DF, Haggerty CM, Halliday BP, Helgadottir A, Hemingway H, Hillege HL, Kardys I, Lind L, Lindgren CM, Lowery BD, Manisty C, Margulies KB, Moon JC, Mordi IR, Morley MP, Morris AD, Morris AP, Morton L, Noursadeghi M, Ostrowski SR, Owens AT, Palmer CNA, Pantazis A, Pedersen OBV, Prasad SK, Shekhar A, Smelser DT, Srinivasan S, Stefansson K, Sveinbjörnsson G, Syrris P, Tammesoo ML, Tayal U, Teder-Laving M, Thorgeirsson G, Thorsteinsdottir U, Tragante V, Trégouët DA, Treibel TA, Ullum H, Valdes AM, van Setten J, van Vugt M, Veluchamy A, Verschuren WMM, Villard E, Yang Y; COVIDsortium; DBDS Genomic Consortium; Estonian Biobank Research Team; HERMES Consortium; Asselbergs FW, Cappola TP, Dube MP, Dunn ME, Ellinor PT, Hingorani AD, Lang CC, Samani NJ, Shah SH, Smith JG, Vasan RS, O'Regan DP, Holm H, Noseda M, Wells Q, Ware JS, Lumbers RT Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy , Nat Genet, 56(12): 2024,2646-2658


Selvaraj S, Patel S, Sauer AJ, McGarrah RW, Jones P, Kwee LC, Windsor SL, Ilkayeva O, Muehlbauer MJ, Newgard CB, Borlaug BA, Kitzman DW, Shah SJ, Margulies KB, Husain M, Inzucchi SE, McGuire DK, Lanfear DE, Javaheri A, Umpierrez G, Mentz RJ, Sharma K, Kosiborod MN, Shah SH Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction , Circ Heart Fail, 17(11): 2024,e011980


Hill MC, Simonson B, Roselli C, Xiao L, Herndon CN, Chaffin M, Mantineo H, Atwa O, Bhasin H, Guedira Y, Bedi KC Jr, Margulies KB, Klattenhoff CA, Tucker NR, Ellinor PT Large-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation , Nat Commun, 15(1): 2024,10002


Chaumont C, Peyster E, Siontis KC, Muser D, Kapa S, Markman TM, Pathak RK, Oraii A, Rodriguez-Queralto O, Anselme F, Margulies KB, Marchlinski FE, Frankel DS Unipolar Voltage Mapping to Predict Recovery of Left Ventricular Ejection Fraction in Patients With Recent-Onset Nonischemic Cardiomyopathy , Circulation: 2024


Boyle TA, Reza N, Hyman M, Supple G, See VY, Marzolf A, Hornsby N, de Feria A, Wang T, Margulies KB, Owens AT, Frankel DS Atrial Fibrillation in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy: Real-World Incidence, Management, and Outcomes , JACC Clin Electrophysiol, S2405-500X(24): 2024


Doan KV, Luongo TS, Ts'olo TT, Lee WD, Frederick DW, Mukherjee S, Adzika GK, Perry CE, Gaspar RB, Walker N, Blair MC, Bye N, Davis JG, Holman CD, Chu Q, Wang L, Rabinowitz JD, Kelly DP, Cappola TP, Margulies KB, Baur JA Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics , Nat Cardiovasc Res, 3(10): 2024,1236-1248


Lu F, Liou C, Ma Q, Wu Z, Xue B, Xia Y, Xia S, Trembley MA, Ponek A, Xie W, Shani K, Bortolin RH, Prondzynski M, Berkson P, Zhang X, Naya FJ, Bedi KC, Margulies KB, Zhang D, Parker KK, Pu WT Virally delivered CMYA5 enhances the assembly of cardiac dyads , Nat Biomed Eng: 2024


Meddeb M, Koleini N, Binek A, Keykhaei M, Darehgazani R, Kwon S, Aboaf C, Margulies KB, Bedi KC Jr, Lehar M, Sharma K, Hahn VS, Van Eyk JE, Drachenberg CI, Kass DA Myocardial ultrastructure of human heart failure with preserved ejection fraction , Nat Cardiovasc Res, 3(8): 2024,907-914


Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, Van Der Laan S, Prosser BL, Margulies KB Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction , Sci Transl Med, 16(756): 2024,eadm8842


Lazaropoulos MP, Gibb AA, Chapski DJ, Nair AA, Reiter AN, Roy R, Eaton DM, Bedi KC Jr, Margulies KB, Wellen KE, Estarás C, Vondriska TM, Elrod JW. Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program , Nat Cardiovasc Res, 3(7): 2024,869-882


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