Kenneth B. Margulies, MD

he/his
Cardiology
Accepting new patients
Sees patients age 18 and up
Penn Heart and Vascular Center
Penn Medicine Provider

About me

  • Research Director, Heart Failure/Transplantation
  • Director, Cardiology Clinical Research Unit
  • Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
  • Professor of Medicine in Physiology

I am a physician-scientist with a clinical practice focused on Advanced Heart Failure and Transplant Cardiology and Inherited Cardiomyopathies.

My education and training

  • Medical School: Thomas Jefferson University
  • Residency: Mayo Clinic
  • Fellowship: Mayo Clinic

Spoken languages

English
English

Reviews

Average Rating

212 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
August 2026
the doctor is a pure professional as always!!!
Anonymous
July 2026
thorough
Anonymous
June 2026
he has made me feel 100% better in my health.
Anonymous
June 2026
excellent doctor

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Margulies is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Hahn VS, Chaffin M, Simonson B, Jenkin SC, Mulligan AS, Rezaee M, Bedi KC Jr, Margulies KB, Klattenhoff CA, Sharma K, Kass DA, Ellinor PT. Single-Cell Analysis of Human Heart Failure With Preserved Ejection Fraction. , Circ Res, 139(2): 2026


Shen KM, Shields EJ, Barka V, Karnay A, Kurzlechner LM, Yang JD, Wang Q, Lee BW, Suay-Corredera C, Nguyen SC, Joyce EF, Margulies KB, Prosser BL, Shah PP, Jain R. The cytoskeleton contributes to abnormal genome-lamina interactions in LMNA-deficient cardiomyocytes. , J Cell Biol, 225(5): 2026


Tanosaki S, Zhang Y, Bedi K, Margulies K, Cox JE, Arany Z, Abel ED. Choice of cardioplegia influences metabolomics of human cardiac tissue. , Proc Natl Acad Sci U S A, 123(20): 2026


Kim DD, Madabhushi A, Margulies KB, Peyster EG. An Integrated Clinical-Histopathologic Prediction Model for Cardiac Allograft Rejection: Translating Machine Learning into Clinical Risk Frameworks. , J Heart Lung Transplant: 2026


Gao W, Hu P, Wick B, Qiu Q, Zhang H, Li Y, Kang X, Bedi K, Haeussler M, Sasaki K, Margulies K, Wu H. An integrative single-nucleus multiomic atlas of the human left ventricle identifies gene regulatory network dynamics across cardiac development, aging, and disease. , Genome Biol, 27(1): 2026


Scarborough EA, Randell RM, Uchida K, Stone KR, Margulies KB, Prosser BL Microtubule dynamics control the direction of cardiomyocyte growth. , Science: 2026


Jani VP, Rhodehamel M, Fenwick AJ, Ma W, Fisher E, Giannakopoulos MT, Moon S, Castillo RL, Kennedy LM, Irving TC, Tardiff JC, Murphy E, Chaerkady R, Wang Q, Barry ME, Hahn VS, Sharma K, Margulies KB, Bedi KC Jr, Cammarato A, Kass DA Severe obesity in human HFpEF alters contractile protein function and organization. , Science: 2026


Sunderland N, Asselin G, Henry A, Nelson CP, Lemieux Perreault LP, Asselbergs FW, Boersma E, Cappola TP, Chazara O, Chutkow W, Cyr MC, Gkatzionis A, Gui H, Haefliger C, Hedman ÅK, Hillege H, Hyde CL, Kamanu FK, Kardys I, Koekemoer AL, Kraus WE, Lang CC, Malarstig A, Margulies KB, Marston NA, Melloni GEM, Morley MP, O'Donoghue ML, Owens AT, Paul DS, Tilling K, van der Harst P, van Setten J, van Vugt M, Verweij N, Veluchamy A, Wallentin L, Wang X, Xing H, Yang Y, White HD, Zannad F, Smith JG, Brunner-La Rocca HP, Lanfear DE, Mann DL, de Denus S, Tardif JC, Voors AA, Samani NJ, Ellinor PT, Ruff CT, Sabatine MS, Sattar N, McMurray JJV, Paternoster L, Dubé MP, Lumbers RT. Body Mass Index, Clinical Outcomes, and Mortality in Heart Failure: A Mendelian Randomization Study. , J Am Coll Cardiol: 2026


Pitoulis F, Pamias-Lopez B, Bedi K, Cheng L, Lee B, Acker M, Peyster E, Margulies K, Prosser B, Ibrahim M Junctophilin-2 abundance is unaltered in human heart failure samples with disrupted T-tubules and contractility. , J Mol Cell Cardiol., 215: 2026


Ibrahim M, Courelli V, Cheng L, Song L, Pamias-Lopez B, Vite A, Toubat O, Pitoulis F, Prosser B, Margulies K. T-tubular remodeling occurs in a cardiomyocyte-autonomous manner following pathological mechanical stiffness exposure. , J Mol Cell Cardiol Plus: 2026


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