Description of Research Expertise:
1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine.
2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors.
3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
Ong Yi Hong, Dimofte Andreaa, Kim Michele M, Finlay Jarod C, Sheng Tianqi, Singhal Sunil, Cengel Keith A, Yodh Arjun G, Busch Theresa M, Zhu Timothy C: Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy. Photochemistry and photobiology : 2019.
Friedberg Joseph S, Simone Charles B, Culligan Melissa J, Putt Mary E, Barsky Andrew R, Katz Sharyn, Cengel Keith A: Posterior Intercostal Lymph Nodes Double Recurrence and Death Risk in Malignant Pleural Mesothelioma. The Annals of thoracic surgery : 2019.
Grewal Amardeep S, Min Eun Jeong, Long Qi, Grewal Sharonjit K, Jain Varsha, Levin William P, Cengel Keith A, Swisher-McClure Samuel, Aggarwal Charu, Bauml Joshua M, Singh Aditi, Ciunci Christine, Cohen Roger B, Langer Corey, Feigenberg Steven J, Berman Abigail T: Early Tumor and Nodal Response in Patients with Locally-advanced NSCLC Predict for Oncologic Outcomes in Patients Treated with Concurrent Proton Therapy and Chemotherapy: Tumor Regression Predicts Outcomes in LA-NSCLC. International journal of radiation oncology, biology, physics : 2019.
Zhu Timothy C, Ong Yihong, Kim Michele M, Liang Xing, Finlay Jarod C, Dimofte Andreea, Simone Nd Charles B, Friedberg Joseph S, Busch Theresa M, Glatstein Eli, Cengel Keith A: Evaluation of Light Fluence Distribution Using an IR Navigation System for HPPH-mediated Pleural Photodynamic Therapy (pPDT). Photochemistry and photobiology : 2019.
Chinniah Chimbu, Aguarin Louise, Cheng Phillip, Decesaris Cristina, Cutillo Alicia, Berman Abigail T, Frick Melissa, Doucette Abigail, Cengel Keith A, Levin William, Hahn Stephen, Dorsey Jay F, Simone Charles B, Kao Gary D: Early Detection of Recurrence in Patients With Locally Advanced Non-Small-Cell Lung Cancer via Circulating Tumor Cell Analysis. Clinical lung cancer 20 (5): 384-390.e2,2019.
Berger Ian, Cengel Keith A, Simone Charles B, Alley Evan W, Roshkovan Leonid, Haas Andrew R, Patel Akash M, Khalid Urooj, Culligan Melissa J, McNulty Sally, Singhal Sunil, Friedberg Joseph S, Katz Sharyn I: Lymphangitic carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Lung cancer (Amsterdam, Netherlands) 132 : 94-98,2019.
Kim Michele, Irmen Peyton, Shoniyozov Khayrullo, Verginadis Ioannis I, Cengel Keith A, Koumenis Costas, Metz James M, Dong Lei, Diffenderfer Eric: Design and commissioning of an image-guided small animal radiation platform and quality assurance protocol for integrated proton and x-ray radiobiology research. Physics in medicine and biology : 2019.
Luna José Marcio, Chao Hann-Hsiang, Diffenderfer Eric S, Valdes Gilmer, Chinniah Chidambaram, Ma Grace, Cengel Keith A, Solberg Timothy D, Berman Abigail T, Simone Charles B: Predicting radiation pneumonitis in locally advanced stage II-III non-small cell lung cancer using machine learning. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 133 : 106-112,2019.
Cramer Gwendolyn, Shin Michael, Hagan Sarah, Katz Sharyn I, Simone Charles B, Busch Theresa M, Cengel Keith A: Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture. Photochemistry and photobiology 95 (1): 397-405,2019.
Rice Stephanie R, Li Yun R, Busch Theresa M, Kim Michele M, McNulty Sally, Dimofte Andrea, Zhu Timothy C, Cengel Keith A, Simone Charles B: A Novel Prospective Study Assessing the Combination of Photodynamic Therapy and Proton Radiation Therapy: Safety and Outcomes When Treating Malignant Pleural Mesothelioma. Photochemistry and photobiology 95 (1): 411-418,2019.
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