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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Perelman Center for Advanced Medicine
West Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Penn Presbyterian Medical Center
1st Floor, Pavilion for Advanced Care (PAC), Suite 100
51 N. 39th Street
Philadelphia, PA 19104
A facility of Penn Presbyterian Medical Center
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RESEARCH INTERESTS:1. Defining Mechanisms and Reducing Toxicity from Normal Tissue Damage Caused by Ionizing Radiation: These projects center on modeling the physical patterns of dose deposition by x-rays, gamma rays and charged particles and determining the mechanism(s) that lead to normal tissue toxicity. From a greater understanding of these mechanisms, these projects seek to identify and formulate potential radiation protectors and mitigators for use in human medicine. 2. Cellular Signaling and PDT cytotoxicity: This project is focused on defining the molecular mechanism by which PDT-initiated growth factor and anti-oxidant signaling leads to decreased PDT-mediated cytotoxicity in human cancer cells and tumors. 3. Clinical trials of RT and PDT: These projects involve using insights gained from pre-clinical studies to design early phase interventional trials for patients with cancers that are difficult to treat using current standard modalities.
Luna José Marcio, Chao Hann-Hsiang, Shinohara Russel T, Ungar Lyle H, Cengel Keith A, Pryma Daniel A, Chinniah Chidambaram, Berman Abigail T, Katz Sharyn I, Kontos Despina, Simone Charles B, Diffenderfer Eric S: Machine learning highlights the deficiency of conventional dosimetric constraints for prevention of high-grade radiation esophagitis in non-small cell lung cancer treated with chemoradiation. Clinical and translational radiation oncology 22 : 69-75,2020.
Cramer Gwendolyn, Lewis Robert, Gymarty Ashley, Hagan Sarah, Mickler Michela, Evans Sydney, Punekar Salman R, Shuman Lee, Simone Charles B, Hahn Stephen M, Busch Theresa M, Fraker Douglass, Cengel Keith A: Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative-Mediated Intraperitoneal Photodynamic Therapy in a Canine Model. Photochemistry and photobiology : 2020.
Busch Theresa M, Cengel Keith A, Zhu Timothy C: In Memoriam Jarod C. Finlay, PhD. Photochemistry and photobiology 96 (2): 218,2020.
Cramer Gwendolyn M, Sandell Meo Julia, Finlay Jarod C, Zhu Timothy C, Busch Theresa M, Cengel Keith A: In vivo Spectroscopic Evaluation of the Intraperitoneal Cavity in Canines. Photochemistry and photobiology : 2020.
Dupre Pamela J, Ong Yi Hong, Friedberg Joseph, Singhal Sunil, Carter Shirron, Simone Charles B, Finlay Jarod C, Zhu Timothy C, Cengel Keith A, Busch Theresa M: Light Fluence Rate and Tissue Oxygenation (S O ) Distributions Within the Thoracic Cavity of Patients Receiving Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma. Photochemistry and photobiology : 2020.
Kim Michele M, Zhu Timothy C, Ong Yi Hong, Finlay Jarod C, Dimofte Andreea, Singhal Sunil, Glatstein Eli, Cengel Keith A: Infrared navigation system for light dosimetry during pleural photodynamic therapy. Physics in medicine and biology : 2020.
Frick Melissa A, Feigenberg Steven J, Jean-Baptiste Samuel R, Aguarin Louise A, Mendes Amberly, Chinniah Chimbu, Swisher-McClure Sam, Berman Abigail, Levin William, Cengel Keith A, Hahn Stephen M, Dorsey Jay F, Simone Charles B, Kao Gary D: Circulating Tumor Cells Are Associated with Recurrent Disease in Patients with Early-stage Non-small Cell Lung Cancer Treated with Stereotactic Body Radiotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research : 2020.
Diffenderfer Eric S, Verginadis Ioannis I, Kim Michele M, Shoniyozov Khayrullo, Velalopoulou Anastasia, Goia Denisa, Putt Mary, Hagan Sarah, Avery Stephen, Teo Kevin, Zou Wei, Lin Alexander, Swisher-McClure Samuel, Koch Cameron, Kennedy Ann R, Minn Andy, Maity Amit, Busch Theresa M, Dong Lei, Koumenis Costas, Metz James, Cengel Keith A: Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System. International journal of radiation oncology, biology, physics 106 (2): 440-448,2020.
Ong Yi Hong, Dimofte Andreaa, Kim Michele M, Finlay Jarod C, Sheng Tianqi, Singhal Sunil, Cengel Keith A, Yodh Arjun G, Busch Theresa M, Zhu Timothy C: Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy. Photochemistry and photobiology 96 (2): 340-348,2019.
Friedberg JS, Simone CB, Culligan MJ, Putt ME, Barsky AR, Katz S, Cengel KA: Posterior Intercostal Lymph Nodes Double Recurrence and Death Risk in Malignant Pleural Mesothelioma. Ann Thorac Surg S0003-4975 (19): 31588-7,2019.
Smilow Center for Translational Research, Room 8-136Univ of Pennsylvania, Perelman School of Medicine3400 Civic Center Blvd, Bldg 421
Patient appointments: 800-789-7366