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Kathleen E. O'Neill, MD, MTR

Kathleen E. O'Neill, MD, MTR Physician

Co-Principal Investigator UNTIL Trial Assistant Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

Languages spoken:

  • Spanish

Dr. O'Neill is employed by Penn Medicine.

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About Dr. Kathleen E. O'Neill

Dr. O’Neill is an attending surgeon specializing in reproductive endocrinology and infertility. She also serves as an assistant professor of obstetrics and gynecology and is the co-principal investigator of the Uterus Transplant for Uterine Factor Infertility (UNTIL) Trial.

Clinical Specialties

Specialty:

  • Reproductive Endocrinology and Infertility

Programs & Centers:

Board Certification:

  • Obstetrics and Gynecology, 2014

Clinical Expertise:

  • Absolute Uterine Factor Infertility
  • Adrenogenital Syndrome
  • Amenorrhea
  • Anovulatory Bleeding
  • Arcuate Uterus
  • Assisted Reproductive Technology (ART)
  • Asthenospermia
  • Bicornuate Uterus
  • Congenital Adrenal Hyperplasia
  • Congenital Uterine Anomaly
  • Delayed Menarche
  • Delayed Puberty
  • Diminished Ovarian Reserve
  • Egg Donation
  • Egg Retrieval
  • Embryo Transfer
  • Endometrioma
  • Endometriosis
  • Fertility Preservation
  • Fertility Problem
  • Fibroid Tumors Removal
  • Gonadal Dysgenesis
  • Gynecologic Disorders of Athletes
  • Hypogonadism
  • Hysteroscopic Myomectomy
  • Hysteroscopy
  • Imperforate Hymen
  • In Vitro Fertilization (IVF)
  • Infertility
  • Intracytoplasmic Sperm Injection (ICSI)
  • Intrauterine Insemination (IUI)
  • Irregular Menstruation
  • Laparoscopic Myomectomy
  • Leiomyoma
  • Menstrual Disorders
  • Menstrual Disorders in Athletes
  • Mullerian Anomalies (Müllerian Duct Anomalies)
  • Oligomenorrhea
  • Ovarian Dysfunction
  • Ovarian Failure
  • Ovulation Induction
  • Premature Menopause (Premature Ovarian Insufficiency)
  • Primary Amenorrhea
  • Primary Ovarian Insufficiency
  • Recurrent Pregnancy Loss
  • Secondary Amenorrhea
  • Semen Analysis
  • Septate Hymen
  • Septate Uterus
  • Sperm Cryopreservation (Sperm Banking)
  • Surrogacy
  • Tubal Diseases
  • Tubal Factor Infertility
  • Tubal Ligation Reversal
  • Unexplained Infertility
  • Unicornuate Uterus
  • Uterine Abnormality
  • Uterine Bleeding
  • Uterine Fibroid Embolization (UFE)
  • Uterine Fibroid Embolization Counseling
  • Uterine Fibroids (Leiomyomas)
  • Uterine Infertility
  • Uterine Myoma
  • Uterine Polyps (Endometrial Polyps)
  • Uterine Surgery
  • Uterine Transplant
  • Uterus Didelphys
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Barnes-Jewish Hospital - Washington University, St. Louis
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Congress of Obstetricians and Gynecologists, Junior Fellow, National American Society for Reproductive Medicine, National Philadelphia Area Reproductive Endocrine Society, Local

Hospital Affiliation

Dr. O'Neill is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Early embryo development, unexplained infertility, endometrium, uterus transplant

Selected Publications:

O'Neill K, Alexander J, Azuma R, Xiao R, Snyder NW, Mesaros CA, Blair IA, Pinney SE: Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner. Int J Mo Sci 19 (9): 2018.

Stuart TJ, O'Neill K, Condon D, Sasson I, Sen P, Xia Y, Simmons RA: Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse. Biol Repro 98(6):795-809 : 2018.

O'Neill KE, Senapati S, Maina I, Gracia C, Dokras A: GnRH agonist with low-dose hCG (dual trigger) is associated with higher risk of severe ovarian hyperstimulation syndrome compared to GnRH agonist alone. J Assist Reprod Genet 33 (9): 1175-1184,2016.

O'Neill K, Senapati S, Dokras A: Use of gonadotropin-releasing hormone agonist (GnRHa) trigger during IVF is associated with similar endocrine profiles and oocyte measures in women with and without PCOS Fertil Steril 103(1):264-69 : 2015.

O'Neill K, Tuuli M, Odibo A, Odem R, Cooper A: Sex-related growth differences are present but not enhanced in in vitro fertilization pregnancies Fertil Steril 101 (2): 407-412,2014.

Tsai J, Schulte M, O'Neill K, Chi MM, Frolova AI, Moley KH: Glucosamine inhibits decidualization of human endometrial stromal cells and decreases litter sizes in mice Biol Reprod 89 (1): 16,2013.

Cooper A, O'Neill K, Allsworth J, Jungheim E, Odibo A, Gray D, Ratts V, Moley K, Odem R: Smaller fetal size in singletons after infertility therapies: the influence of technology and the underlying infertility Fertil Steril 96 (5): 2011.

Frolova A, O'Neill K, Moley K: Dehydroepiandrosterone inhibits glucose flux through the pentose phosphate pathway in human and mouse endometrial stromal cells, preventing decidualization and implantation Molec Endocrinol 25 (8): 1444-1455,2011.

Ganesh SK, Joo J, Skelding K, Mehta L, Zheng G, O'Neill K, Billings EM, Helgadottir A, Andersen K. Thorgeirsson G, Gudnason T, Geller NL, Simari RD, Holmes DR, O'Neill WW, Nabel EG: Time course analysis of gene expression identifies multiple genes with differential expression in patients with in-stent restenosis. BMC Med Genomics 4:20 : 2011.

Cahill AG, Parks L, Harper L, Heitmann E, O'Neill K: Abnormal fetal heart rate tracings in patients with thick meconium staining of the amniotic fluid Am J Obstet Gynecol 200 (3): 342-343,2009.

Academic Contact Info

University of Pennsylvania
Department of Obstetrics and Gynecology
Division of Reproductive Endocrinology and Infertility
421 Curie Blvd, 1353 BRB II/III

Philadelphia, PA 19104
Phone: (215) 898-0825
Patient appointments: 800-789-7366 (PENN)