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Kathleen E. O'Neill, MD, MTR

Kathleen E. O'Neill, MD, MTR Physician

Assistant Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

Languages spoken:

  • Spanish

Dr. O'Neill is employed by Penn Medicine.

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Clinical Specialties


  • Reproductive Endocrinology and Infertility

Programs & Centers:

Board Certification:

  • Obstetrics and Gynecology, 2014

Clinical Expertise:

  • Adolescent Gynecologic Surgery
  • Connective Tissue Disease and Pregnancy
  • Endoscopic Laser Surgery
  • Gynecologic Surgery
  • Hysteroscopic Surgery
  • In Vitro Fertilization (IVF)
  • Laparoscopic Surgery
  • Mullerian Anomalies (Müllerian Duct Anomalies)
  • Recurrent Pregnancy Loss (Recurrent Miscarriage)
  • Reproductive Endocrinology

Description of Clinical Expertise

Mullerian anomalies and Uterus transplant

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: Barnes-Jewish Hospital - Washington University, St. Louis
Fellowship: Hospital of the University of Pennsylvania


American Congress of Obstetricians and Gynecologists, Junior Fellow, National American Society for Reproductive Medicine, National Philadelphia Area Reproductive Endocrine Society, Local

Hospital Affiliation

Dr. O'Neill is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Early embryo development, unexplained infertility, endometrium, uterus transplant

Selected Publications:

O'Neill K, Stuart TJ, Condon D, Sasson I, Sen P, Xia Y, Simmons RA.: Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse Biology of Reproduction : 2018.

Practice Committee and the Task Force on Guidance for Uterus Transplant of the American Society for Reproductive Medicine: American Society for Reproductive Medicine Position Statement on Uterus Transplantation American Society for Reproductive Medicine : 2018.

Feldman RA, O'Neill K, Butts SF, Dokras A: Antimullerian hormone levels and cardiometabolic risk in young women with polycystic ovary syndrome Fertil Steril 107 (1): 276-281,2017.

O'Neill KE, Stuart T, Condon D, Mainigi M, Simmons RA: The placental metabolome is a window to long-term metabolic health: lessons from an obesogenice mouse model. Oral presentation, American Society for Reproductive Medicine Meeting, Salt Lake City, UT : 2016.

O'Neill KE, Senapati S, Maina I, Gracia C, Dokras AD.: GnRH agonist with low-dose hCG (dual trigger) is associated with higher risk of severe ovarian hyperstimulation syndrome compared to GnRH agonist alone. J Assist Reprod Genet 33 (9): 1175-1184,2016.

O'Neill KE, Mainigi M, Stuart T, Condon D, Simmons RA: Sex differences in gene expression are restricted to extraembryonic tissue in early post-implantation embryos. Oral presentation, Society for Reproductive Investigation Meeting, Montreal, Canada : 2016.

O'Neill KE, Stuart T, Mainigi M, Simmons RA: Antioxidants reverse obesity-induced transcriptomic changes in oocytes. Oral presentation, Society for Gynecologic Investigation Meeting, San Francisco : 2015.

O'Neill K, Senapati S, Dokras A: Use of gonadotropin-releasing hormone agonist (GnRHa) trigger during IVF is associated with similar endocrine profiles and oocyte measures in women with and without PCOS Fertil Steril 103(1):264-69 : 2015.

O'Neill KE, Coutifaris C: Gonadotropin-releasing hormone agonist trigger in clinical in vitro fertilization: Can the suboptimal candidate be defined? Fertil Steril 104 (3): 555-556,2015.

O'Neill KE, Senapati S, Gracia C, Dokras A: GnRH agonist with lose-dose hCG co-trigger is associated with higher risk of severe OHSS than GnRH agonist alone. Oral presentation, American Society for Reproductive Medicine Meeting, Honolulu, HI : 2014.

Academic Contact Info

University of Pennsylvania
Department of Obstetrics and Gynecology
Division of Reproductive Endocrinology and Infertility
421 Curie Blvd, 1353 BRB II/III

Philadelphia, PA 19104
Phone: (215) 898-0825
Patient appointments: 800-789-7366 (PENN)