Find a Doctor or Practice Location

You can also search for providers and practices at Penn Medicine Lancaster General Health or Princeton Health.

within
I am searching for a
Reset Form
Katherine L. Nathanson, MD

Katherine L. Nathanson, MD Physician

Professor of Medicine Professor of Genetics

Languages spoken:

  • French

Dr. Nathanson is employed by Penn Medicine.

About Dr. Katherine L. Nathanson

Recognized by America's Top Doctors 2015 – 2017

Recognized in Philadelphia magazine's May 2018 Top Docs issue

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties

Specialty:

  • Medical Genetics

Programs & Centers:

Board Certification:

  • Medical Genetics, 1999

Clinical Expertise:

  • Acoustic Neuroma (Vestibular Schwannoma)
  • Birt-Hogg-Dubé Syndrome
  • Cancer Genetic Testing
  • Genetic and Rare Diseases Treatments and Procedures
  • Genetic Counseling
  • Genetic Skin Disorders
  • Genetic Testing
  • Hereditary Cancer Syndrome
  • Hereditary Papillary Renal Cancer
  • Klinefelter Syndrome (XXY Syndrome)
  • Li-Fraumeni Syndrome (LFS)
  • Neurofibromatosis Type 1 (NF1)
  • Paraganglioma
  • Pheocromocytoma
  • Schwannomatosis
  • Tuberous Sclerosis
  • Von Hippel Lindau Syndrome (VHL)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Beth Israel Deaconess Medical Center
Fellowship: Children's Hospital of Philadelphia

Memberships

American Association for Cancer Research, National American College of Medical Genetics, National American College of Physicians, National American Society for Clinical Investigation, National American Society for Human Genetics, National Breast Cancer Information Core Steering Committee, National Movember GAP5 Translational Research Steering Committee (Testicular Cancer), International National Institutes of Health, National Cancer Institute Loan Repayment Program Study Section, National National Institutes of Health, National Cancer Institute, Special Emphasis Panel, Feasibility and Planning Studies for SPOREs to Investigate Cancer Health Disparities (P20), National National Institutes of Health, National Cancer Institute, Special Emphasis Panel, RFA-CA-17-035-Pre-Cancer Atlas Research Centers, National Tuberous Sclerosis Alliance, National

Hospital Affiliation

Dr. Nathanson is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Nathanson’s research focuses on the genetics of human cancer, both germline changes which confer susceptibility to cancer and somatic genetic changes associated with outcome.

Her research projects fall into several areas:

1) Identification and characterization of germline genetic changes associated with breast cancer susceptibility. These projects utilize two sample sets, a large clinical database of high risk breast cancer patients and a case-control study of white and black patients with breast cancer. Currently the projects in the laboratory focus on resequencing of BRCA1-associated genes as candidate breast cancer susceptibility genes in patients with high risk breast cancer and studying copy number variation as associated with potential susceptibility to high risk breast cancer in families with multiple cases of breast cancer.

2) Identification of genetic changes associated with testicular cancer susceptibility in case-control sample set. Dr. Nathanson recently completed a successful genome wide association study in testicular cancer, and is in the process of designing and doing a number of follow-up studies.

3) Identification of somatic genetic markers in melanoma as determinants of response to therapy. The projects in the laboratory focus on several aspects of melanoma genetics including genotyping patients to determine targeted therapy selection, using genetics and genomics to sub-set melanomas, as well as understand response to therapy, and identify novel genes important in melanoma progression.

Selected Publications:

MacFarland SP, Zelley K, Long JM, McKenna D, Mamula P, Domchek SM, Nathanson KL, Brodeur GM, Rustgi AK, Katona BW, Maxwell KN.: Earlier colorectal cancer screening may be necessary in patients with Li-Fraumeni Syndrome Gastroenterology 156 (1): 273-274,2019.

Zhao H, Mitra N, Kanetsky PA, Nathanson KL, Rebbeck TR: A practical approach to adjusting for population stratification in genome-wide association studies: principal components and propensity scores (PCAPS) Stat Appl Genet Mol Biol. : 2018.

Parekh V, Sobanko J, Miller CJ, Karakousis G, Xu W, Letrero R, Elenitsas R, Xu X, Elder DE, Amaravadi R, Schuchter LM, Nathanson KL, Wilson MA, Chu EY: NRAS Q61R and BRAF G466A mutations in atypical melanocytic lesions newly arising in advanced melanoma patients treated with vemurafenib J Cutan Pathol. : 2018.

Jiang Y, Wang R, Urrutia E, Anastopoulos IN, Nathanson KL, Zhang NR.: CODEX2: full-spectrum copy number variation detection by high-throughput DNA sequencing Genome Biol. 19 (1): 202,2018.

Wang S, Huo D, Ogundiran TO, Ojengbede O, Zheng W, Nathanson KL, Nemesure B, Ambs S, Olopade OI, Zheng Y: Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry Mol Carcinog 57 (10): 1311-1318,2018.

Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Randell S, Sadek N, Beroard A, Xiao M, Tian T, Tan J, Saeed U, Sugarman E, Krepler C, Brafford PA, Sproesser K, Murugan S, Somasundaram R, Garman B, Wubbenhorst B, Woo J, Yin X, Liu Q, Frederick DT, Miao B, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Kwong LN, Amaravadi RK, Lu Y, Boland G, Wei Z, Nathanson KL, Mills GB, Flaherty KT, Shay JW, Herlyn M, Vasilopoulos T, Herbig U: Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma Clin Cancer Res 24 (19): 4771-4784,2018.

Qian F, Wang S, Mitchell J, McGuffog L, Barrowdale D, Leslie G, Oosterwijk JC, Chung WK, Evans DG, Engel C, Kast K, Aalfs CM, Adank MA, Adlard J, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Arun BK, Ausems MGEM, Azzollini J, Barouk-Simonet E, Barwell J, Belotti M, Benitez J, Berger A, Borg A, Bradbury AR, Brunet J, Buys SS, Caldes T, Caligo MA, Campbell I, Caputo SM, Chiquette J, Claes KBM, Margriet Collée J, Couch FJ, Coupier I, Daly MB, Davidson R, Diez O, Domchek SM, Donaldson A, Dorfling CM: Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study J Natl Cancer Inst. : 2018.

Margolis DJ, Mitra N, Gochnauer H, Wubbenhorst B, D'Andrea K, Kraya A, Hoffstad O, Gupta J, Kim B, Yan A, Chiesa Fuxench Z, Nathanson KL: Uncommon filaggrin variants are associated with persistent atopic dermatitis in African Americans J Invest Dermatol 138 (7): 1501-1506,2018.

Stewart DR, Korf BR, Nathanson KL, Stevenson DA, Yohay K.: Care of adults with neurofibromatosis type 1: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG) Genet Med 20 (7): 671-682,2018.

Shen H, Shih J, Hollern DP, Wang L, Bowlby R, Tickoo SK, Thorsson V, Mungall AJ, Newton Y, Hegde AM, Armenia J, Sánchez-Vega F, Pluta J, Pyle LC, Mehra R, Reuter VE, Godoy G, Jones J, Shelley CS, Feldman DR, Vidal DO, Lessel D, Kulis T, Cárcano FM, Leraas KM, Lichtenberg TM, Brooks D, Cherniack AD, Cho J, Heiman DI, Kasaian K, Liu M, Noble MS, Xi L, Zhang H, Zhou W, ZenKlusen JC, Hutter CM, Felau I, Zhang J, Schultz N, Getz G, Meyerson M, Stuart JM; Cancer Genome Atlas Research Network, Akbani R, Laird PW: Integrated Molecular Characterization of Testicular Germ Cell Tumors Cell Rep. 23 (11): 3392-3406,2018.

Academic Contact Info

356 BRB II/III
421 Curie Blvd
University of Pennsylvania

Philadelphia, PA 19104
Phone: (215) 662-4740
Patient appointments: 800-789-7366 (PENN)

Related Links