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Katherine L. Nathanson, MD

Katherine L. Nathanson, MD Physician

Professor of Medicine Professor of Genetics

Languages spoken:

  • French

Dr. Nathanson is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Medical Genetics

Programs & Centers:

Board Certification:

  • Medical Genetics, 1999

Clinical Expertise:

  • Acoustic Neuromas
  • Birt-Hogg-Dubé Syndrome
  • Cancer Genetic Testing
  • Genetic and Rare Diseases Treatments and Procedures
  • Genetic Counseling
  • Genetic Skin Disorders
  • Genetic Testing
  • Hereditary Cancer Syndrome
  • Hereditary Papillary Renal Cancer
  • Klinefelter Syndrome (XXY Syndrome)
  • Li-Fraumeni Syndrome (LFS)
  • Neurofibromatosis Type 1 (NF1)
  • Paragangliomas
  • Pheocromocytoma
  • Schwannomatosis
  • Tuberous Sclerosis
  • Von Hippel Lindau Syndrome (VHL)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Beth Israel Deaconess Medical Center
Fellowship: Children's Hospital of Philadelphia

Memberships

AACR-Kure It Grant for Kidney Cancer Research Scientific Review Committee, National ACMGE Milestones Working Group for Medical Genetics, National American Association for Cancer Research, National American Association for the Advancement of Science, National American College of Medical Genetics, National American College of Physicians , National American Society for Clinical Investigation, National American Society for Human Genetics, National Australian National Health and Medical Research Council, International Breast Cancer Information Core Steering Committee , National Cancer Research UK (UK), International Cancer Research UK, International Cancer Working Group, PhenX Project (sponsored by NHGRI), National Department of Defense Breast Cancer, National Department of Defense Breast Cancer, National Genesis Oncology Trust, New Zealand , International Genome Quebec, International Hidary Foundation-MRA Team Science Awards for Acral Melanoma Genomics, International Lance Armstrong Foundation Study Section, National Melanoma Research Breakthrough Consortium, National Melanoma Research Foundation , National Movember GAP5 Translational Research Steering Committee (Testicular Cancer), International National Cancer Institute Blue Ribbon Panel Working Group - Tumor Evolution and Progression, National National Cancer Institute, Special Emphasis Panel/Scientific Review Group (R21), National National Institutes of Health, Cancer Biomarker Study Section, National National Institutes of Health, Cancer Genetics Study Section, National National Institutes of Health, Cancer Genetics Study Session, National National Institutes of Health, Intramural Site Visit Review, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Laboratory of Translational Genomics, National National Institutes of Health, National Cancer Institute Loan Repayment Program Study Section , National National Institutes of Health, National Cancer Institute, Intramural Site Visit Review, Cancer and Inflammation Program, National National Institutes of Health, National Cancer Institute, National National Institutes of Health, National Cancer Institute, Special Emphasis Panel/Scientific Review Group P20/U54, National National Institutes of Health, NHGRI Special Emphasis Panel ZHG1 HGR-N (J1), T32 review, National Selected for AAMC Mid-Career Women Faculty Professional Development Seminar, Austin TX, National Susan G. Komen for the Cure Grants Program, National TCGA Pheochromocytoma/Paraganglioma Disease Working Group, National TCGA Testicular Germ Cell Tumor Working Group, National Cancer Institute , National Tuberous Sclerosis Alliance, National UK Medical Research Council, International VA MERIT Review - Special Emphasis - Research on Clinical Application of Genetics, National

Hospital Affiliation

Dr. Nathanson is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Dr. Nathanson’s research focuses on the genetics of human cancer, both germline changes which confer susceptibility to cancer and somatic genetic changes associated with outcome.

Her research projects fall into several areas:

1) Identification and characterization of germline genetic changes associated with breast cancer susceptibility. These projects utilize two sample sets, a large clinical database of high risk breast cancer patients and a case-control study of white and black patients with breast cancer. Currently the projects in the laboratory focus on resequencing of BRCA1-associated genes as candidate breast cancer susceptibility genes in patients with high risk breast cancer and studying copy number variation as associated with potential susceptibility to high risk breast cancer in families with multiple cases of breast cancer.

2) Identification of genetic changes associated with testicular cancer susceptibility in case-control sample set. Dr. Nathanson recently completed a successful genome wide association study in testicular cancer, and is in the process of designing and doing a number of follow-up studies.

3) Identification of somatic genetic markers in melanoma as determinants of response to therapy. The projects in the laboratory focus on several aspects of melanoma genetics including genotyping patients to determine targeted therapy selection, using genetics and genomics to sub-set melanomas, as well as understand response to therapy, and identify novel genes important in melanoma progression.

Selected Publications:

Maxwell KN, Wubbenhorst B, Wenz BM, De Sloover D, Pluta J, Emery L, Barrett A, Kraya A, Anastopoulos IN, Yu S, Jiang Y, Chen H, Zhang NR, Hackman N, D'Andrea K, Daber R, Morrissette JJD, Mitra N, Feldman M, Domchek SM, Nathanson KL : BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers Nat Comm 8 (1): 319,2017.

Fishbein L, Ben-Maimon S, Keefe S, Cengel K, Pryma DA, Loaiza-Bonilla A, Fraker DL, Nathanson KL, Cohen DL: SDHB mutation carriers with malignant pheochromocytoma respond better to CVD Endocr Relat Cancer 24 (8): L51-L55,2017.

Wang S, Huo D, Ogundiran TO, Ojengbede O, Zheng W, Nathanson KL, Nemesure B, Ambs S, Olopade OI, Zheng Y: Association of breast cancer risk and the mTOR pathway in women of African ancestry in "The Root" Consortium Carcinogenesis 38 (8): 789-796,2017.

Lecarpentier J, Silvestri V, Kuchenbaecker KB, Barrowdale D, Dennis J, McGuffog L, Soucy P, Leslie G, Rizzolo P, Navazio AS, Valentini V, Zelli V, Lee A, Amin Al Olama A, Tyrer JP, Southey M, John EM, Conner TA, Goldgar DE, Buys SS, Janavicius R, Steele L, Ding YC, Neuhausen SL, Hansen TVO, Osorio A, Weitzel JN, Toss A, Medici V, Cortesi L, Zanna I, Palli D, Radice P, Manoukian S, Peissel B, Azzollini J, Viel A, Cini G, Damante G, Tommasi S, Peterlongo P, Fostira F, Hamann U, Evans DG, Henderson A, Brewer C: Prediction of breast and prostate cancer risks in male BRCA1 and BRCA2 mutation carriers using polygenic risk scores J Clin Oncol 35 (20): 2240-2250,2017.

Feng Y, Rhie SK, Huo D, Ruiz-Narvaez EA, Haddad SA, Ambrosone CB, John EM, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Nyante S, Bandera EV, Ingles SA, Press MF, Deming SL, Rodriguez-Gil JL, Zheng Y, Yao S, Han YJ, Ogundiran TO, Rebbeck TR, Adebamowo C, Ojengbede O, Falusi AG, Hennis A, Nemesure B, Ambs S, Blot W, Cai Q, Signorello L, Nathanson KL, Lunetta KL, Sucheston-Campbell LE, Bensen JT, Chanock SJ, Le Marchand L, Olshan AF, Kolonel LN, Conti DV, Coetzee G, Stram DO, Olopade OI, Palmer JR, Haiman CA: Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry Cancer Epidemiol Biomarkers Prev 26 (7): 1016-1026,2017.

Wang Z, McGlynn KA, Rajpert-De Meyts E, Bishop DT, Chung CC, Dalgaard MD, Greene MH, Gupta R, Grotmol T, Haugen TB, Karlsson R, Litchfield K, Mitra N, Nielsen K, Pyle LC, Schwartz SM, Thorsson V, Vardhanabhuti S, Wiklund F, Turnbull C, Chanock SJ, Kanetsky PA, Nathanson KL; Testicular Cancer Consortium: Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor Nat Genet 49 (7): 1141-1147,2017.

Shaffer SM, Dunagin MC, Torborg SR, Torre EA, Emert B, Krepler C, Beqiri M, Sproesser K, Brafford PA, Xiao M, Eggan E, Anastopoulos IN, Vargas-Garcia CA, Singh A, Nathanson KL, Herlyn M, Raj A: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance. Nature 546 (7658): 431-435,2017.

Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, Dennis J, Pirie A, Riggan MJ, Chornokur G, Earp MA, Lyra PC Jr, Lee JM, Coetzee S, Beesley J, McGuffog L, Soucy P, Dicks E, Lee A, Barrowdale D, Lecarpentier J, Leslie G, Aalfs CM, Aben KK, Adams M, Adlard J, Andrulis IL, Anton-Culver H, Antonenkova N; AOCS study group., Aravantinos G, Arnold N, Arun BK, Arver B, Azzollini J, Balmaña J, Banerjee SN, Barjhoux L, Barkardottir RB, Bean Y, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bermisheva: Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer Nat Genet 49 (5): 680-691,2017.

Fang J, Jia J, Makowski M, Xu M, Wang Z, Zhang T, Hoskins JW, Choi J, Han Y, Zhang M, Thomas J, Kovacs M, Collins I, Dzyadyk M, Thompson A, O'Neill M, Das S, Lan Q, Koster R; PanScan Consortium.; TRICL Consortium.; GenoMEL Consortium., Stolzenberg-Solomon RS, Kraft P, Wolpin BM, Jansen PWTC, Olson S, McGlynn KA, Kanetsky PA, Chatterjee N, Barrett JH, Dunning AM, Taylor JC, Newton-Bishop JA, Bishop DT, Andresson T, Petersen GM, Amos CI, Iles MM, Nathanson KL, Landi MT, Vermeulen M, Brown KM, Amundadottir LT.: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nat Commun 8 : 15034,2017.

Huang AC, Postow MA, Orlowski RJ, Mick R, Bengsch B, Manne S, Xu W, Harmon S, Giles JR, Wenz B, Adamow M, Kuk D, Panageas KS, Carrera C, Wong P, Quagliarello F, Wubbenhorst B, D'Andrea K, Pauken KE, Herati RS, Staupe RP, Schenkel JM,McGettigan S, Kothari S, George SM, Vonderheide RH, Amaravadi RK, Karakousis GC, Schuchter LM, Xu X, Nathanson KL, Wolchok JD, Gangadhar TC, Wherry EJ: T-cell invigoration to tumour burden ratio associated with anti-PD-1 response Nature 545 (7652): 60-65,2017.

Academic Contact Info

356 BRB II/III
421 Curie Blvd
University of Pennsylvania

Philadelphia, PA 19104
Phone: 215-662-4740
Patient appointments: 800-789-7366 (PENN)

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