Description of Research Expertise:
We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections.
Current projects include:
1. The HIV transmission bottleneck and virus phenotype in injection drug users
2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies
3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses
4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure
Lab Personnel:
Benjamin Scheinfeld, technician
D. Brenda Salantes, graduate student
Selected Publications:
Goswami R, Nelson AN, Tu JJ, Dennis M, Feng L, Kumar A, Mangold J, Mangan RJ, Mattingly C, Curtis AD 2nd, Obregon-Perko V, Mavigner M, Pollara J, Shaw GM, Bar KJ, Chahroudi A, De Paris K, Chan C, Van Rompay KKA, Permar SR: Analytical Treatment Interruption after Short-Term Antiretroviral Therapy in a Postnatally Simian-Human Immunodeficiency Virus-Infected Infant Rhesus Macaque Model
MBio 10 (5): pii: e01971-19,2019.
Bar KJ, Coronado E, Hensley-McBain T, O'Connor MA, Osborn JM, Miller C, Gott TM, Wangari S, Iwayama N, Ahrens CY, Smedley J, Moats C, Lynch RM, Haddad EK, Haigwood NL, Fuller DH, Shaw GM, Klatt NR, Manuzak JA: Simian-Human Immunodeficiency Virus SHIV.CH505 Infection of Rhesus Macaques Results in Persistent Viral Replication and Induces Intestinal Immunopathology
J Virol 93 (18): pii: e00372-19,2019.
Nelson AN, Goswami R, Dennis M, Tu J, Mangan RJ, Saha PT, Cain DW, Curtis AD, Shen X, Shaw GM, Bar K, Hudgens M, Pollara J, De Paris K, Van Rompay KKA, Permar SR: Simian-Human Immunodeficiency Virus SHIV CH505-infected infant and adult rhesus macaques exhibit similar HIV Env-specific antibody kinetics, despite distinct T-follicular helper (Tfh) and germinal center B cell landscapes
J Virol : pii: e00168-19,2019.
Zahid MN, Wang S, Learn GH, Abt PL, Blumberg EA, Reese PP, Goldberg DS, Shaw GM, Bar KJ: High multiplicity infection following transplantation of hepatitis C virus-positive organs J Clin Invest 130 : pii: 127203,2019.
Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby D, Dawson L, Dubé K, Eron J, Frater J, Gandhi R, Geleziunas R, Goulder P, Hanna G, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen C, Tressler R, Weiss C, Zheng L, Robb M, Michael N, Mellors J: Recommendations for Analytical Antiretroviral Treatment Interruptions in HIV Research Trials – Report of a Consensus Meeting The Lancet HIV 6 (4): e259-e268,2019.
McLean RC, Reese PP, Acker M, Atluri P, Bermudez C, Goldberg L, Abt PL, Blumberg EA, Van Deerlin VM, Reddy KR, Bloom RD, Hasz R, Suplee L, Sicilia A, Woodards A, Zahid MN, Bar KJ, Porrett P, Levine M, Hornsby N, Gentile C, Smith J, Goldberg DS: Transplanting hepatitis C virus-infected hearts into uninfected recipients: A single-arm trial Am J Transplant : doi: 10.1111/ajt.15311,2019.
Salantes DB, Zheng Y, Mampe F, Srivastava T, Beg S, Lai J, Li JZ, Tressler RL, Koup RA, Hoxie J, Abdel-Mohsen M, Sherrill-Mix S, McCormick K, Overton ET, Bushman FD, Learn GH, Siliciano RF, Siliciano JM, Tebas P, Bar KJ: HIV-1 latent reservoir size and diversity are stable following brief treatment interruption J Clin Invest 128 (7): 3102-3115,2018.
Li F, Ma L, Feng Y, Ruan Y, Hu J, Song H, Liu P, Ma J, Rui B, Kerpen K, Scheinfeld B, Srivastava T, Metzger D, Li H, Bar KJ, Shao Y: HIV-1 and hepatitis C virus selection bottleneck in Chinese people who inject drugs AIDS 32 (3): 309-320,2018.
Barbian HJ, Jackson-Jewett R, Brown CS, Bibollet-Ruche F, Learn GH, Decker T, Kreider EF, Li Y, Denny TN, Sharp PM, Shaw GM, M.D., Lifson JD, Acosta EP, Saag MS, Bar KJ, Hahn BH: Effective Treatment of SIVcpz-Induced Immunodeficiency in a Captive Western Chimpanzee Retrovirology 14 (1): 35,2017.
Bar KJ, Sneller MC, Harrison LJ, Justement SJ, Overton ET, Petrone ME, Salantes BD, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Bazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden KS, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun T-W: Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption NEJM 375 (21): 2037-2050,2016.