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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
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We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections. Current projects include:1. The HIV transmission bottleneck and virus phenotype in injection drug users2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure Lab Personnel:Benjamin Scheinfeld, technicianD. Brenda Salantes, graduate student
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication: CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication Journal of Clinical Investigation 131 (7): 2021.
Li H, Wang S, Lee FH, Roark RS, Murphy AI, Smith J, Zhao C, Rando J, Chohan N, Ding Y, Kim E, Lindemuth E, Bar KJ, Pandrea I, Apetrei C, Keele BF, Lifson JD, Lewis MG, Denny TN, Haynes BF, Hahn BH, Shaw GM: New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure Journal of Virology 71 (21): 2021.
Ziani W, Bauer A, Lu H, Wang X, Wu X, Bar KJ, Li H, Liu D, Shaw GM, Veazey RS, Xu H: Immune responses and viral persistence in SHIV.C.CH848-infected rhesus macaques Journal of Virology 2198 (20): 2021.
Gondim MVP, Sherrill-Mix S, Bibollet-Ruche F, Russell RM, Trimboli S, Smith AG, Li Y, Liu W, Avitto AN, DeVoto JC, Connell J, Fenton-May AE, Pellegrino P, Williams I, Papasavvas E, Lorenzi JCC, Salantes DB, Mampe F, Monroy MA, Cohen YZ, Heath S, Saag MS, Montaner LJ, Collman RG, Siliciano JM, Siliciano RF, Plenderleith LJ, Sharp PM, Caskey M, Nussenzweig MC, Shaw GM, Borrow P, Bar KJ, Hahn BH: Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption Science Translational Medicine 13 (576): 2021.
Obregon-Perko V, Bricker KM, Mensah G, Uddin F, Kumar MR, Fray EJ, Siliciano RF, Schoof N, Horner A, Mavigner M, Liang S, Vanderford T, Sass J, Chan C, Berendam SJ, Bar KJ, Shaw GM, Silvestri G, Fouda GG, Permar SR, Chahroudi A: Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4+ T Cells Journal of Virology 95 (e01669-20): 2020.
Lynn N Bertagnolli, Joseph Varriale, Sarah Sweet, Jacqueline Brockhurst, Francesco R Simonetti, Jennifer White, Subul Beg, Kenneth Lynn, Karam Mounzer, Ian Frank, Pablo Tebas, Katharine J Bar, Luis J Montaner, Robert F Siliciano, Janet D Siliciano: Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1 Proceedings of the National Academy of Sciences 117 (50): 32066-32077,2020.
Roark RS, Li H, Williams WB, Chug H, Mason RD, Gorman J, Wang S, Lee FH, Rando J, Bonsignori M, Hwang KK, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet-Ruche F, Liu W, Connell J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang GY, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond D, Doria-Rose NA, Schramm CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GM.: Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science abd2638 : 2020.
Berendam SJ, Styles TM, Morgan-Asiedu PK, Tenney D, Kumar A, Obregon-Perko V, Bar KJ, Saunders KO, Santra S, De Paris K, Tomaras GD, Chahroudi A, Permar SR, Amara RR, Fouda GG: Systematic assessment of antiviral potency, breadth, and synergy of triple broadly neutralizing antibody combinations against Simian-Human Immunodeficiency Viruses Journal of Virology JVI.01667-20 : 2020.
Dashti A, Waller C, Mavigner M, Schoof N, Bar KJ, Shaw GM, Vanderford T, Liang S, Lifson J, Dunham RM, Ferrari G, Tuyishime M, Lam CK, Nordstrom JL, Margolis DM, Silvestri G, Chahroudi A: SMAC mimetic plus triple combination bispecific HIVxCD3 DART® molecules in SHIV.C.CH505-infected, ART-suppressed rhesus macaques Journal of Virology VI.00793-20. (doi: 10.1128/JVI.00793-20): 2020.
Bauer AM, Ziani W, Lindemuth E, Kuri-Cervantes L, Li H, Lee FH, Watkins M, Xu H, Veazey R, Bar KJ: Novel Transmitted/Founder Simian-Human Immunodeficiency Viruses for Human Immunodeficiency Virus Latency and Cure Research Journal of Virology 94 (8; e01659-19): 2020.
502 D Johnson Pavilion3610 Hamilton Walk
Patient appointments: 800-789-7366