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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
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Responses are measured on a scale of 1 to 5 with 5 being the best score.
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We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections. Current projects include:1. The HIV transmission bottleneck and virus phenotype in injection drug users2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure Lab Personnel:Benjamin Scheinfeld, technicianD. Brenda Salantes, graduate student
O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Hou P, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; Covid-19 Phase 3 Prevention Trial Team.: Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med
385 (13): 1185-1195,2021.
Weimin Liu, Ronnie M Russell, Frederic Bibollet-Ruche, Ashwin N Skelly, Scott Sherrill-Mix, Drew A Freeman, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E Hensley, Thomas Ketas, Albert Cupo, Victor M Cruz Portillo, John P Moore, Paul D Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard, Michael S Saag, Randall S Davis, George M Shaw, William J Britt, Sixto M Leal Jr, Paul Goepfert, Beatrice H Hahn: Predictors of Nonseroconversion after SARS-CoV-2 Infection Emerg Infect Dis 27(9):2454-2458 (9): 2454-2458,2021.
O'Brien MP, Forleo-Neto E, Sarkar N, Isa F, Hou P, Chan KC, Musser BJ, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM.: Subcutaneous REGEN-COV Antibody Combination in Early SARS-CoV-2 Infection medRxiv : 2021.
CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication: CCR5-edited CD4+ T cells augment HIV-specific immunity to enable post-rebound control of HIV replication J Clin Invest 131 (7): e144486,2021.
Li H, Wang S, Lee FH, Roark RS, Murphy AI, Smith J, Zhao C, Rando J, Chohan N, Ding Y, Kim E, Lindemuth E, Bar KJ, Pandrea I, Apetrei C, Keele BF, Lifson JD, Lewis MG, Denny TN, Haynes BF, Hahn BH, Shaw GM: New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure J Virol 71 (21): e00071-21,2021.
Ziani W, Bauer A, Lu H, Wang X, Wu X, Bar KJ, Li H, Liu D, Shaw GM, Veazey RS, Xu H: Immune responses and viral persistence in SHIV.C.CH848-infected rhesus macaques J Virol 2198 (20): e02198-20,2021.
Gondim MVP, Sherrill-Mix S, Bibollet-Ruche F, Russell RM, Trimboli S, Smith AG, Li Y, Liu W, Avitto AN, DeVoto JC, Connell J, Fenton-May AE, Pellegrino P, Williams I, Papasavvas E, Lorenzi JCC, Salantes DB, Mampe F, Monroy MA, Cohen YZ, Heath S, Saag MS, Montaner LJ, Collman RG, Siliciano JM, Siliciano RF, Plenderleith LJ, Sharp PM, Caskey M, Nussenzweig MC, Shaw GM, Borrow P, Bar KJ, Hahn BH: Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption Sci Transl Med 13 (576): 2021.
Obregon-Perko V, Bricker KM, Mensah G, Uddin F, Kumar MR, Fray EJ, Siliciano RF, Schoof N, Horner A, Mavigner M, Liang S, Vanderford T, Sass J, Chan C, Berendam SJ, Bar KJ, Shaw GM, Silvestri G, Fouda GG, Permar SR, Chahroudi A: Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4+ T Cells J Virol 95 (2): e01669-20,2020.
Lynn N Bertagnolli, Joseph Varriale, Sarah Sweet, Jacqueline Brockhurst, Francesco R Simonetti, Jennifer White, Subul Beg, Kenneth Lynn, Karam Mounzer, Ian Frank, Pablo Tebas, Katharine J Bar, Luis J Montaner, Robert F Siliciano, Janet D Siliciano: Autologous IgG antibodies block outgrowth of a substantial but variable fraction of viruses in the latent reservoir for HIV-1 Proceed Nat Acad Sci 117 (50): 32066-32077,2020.
Berendam SJ, Styles TM, Morgan-Asiedu PK, Tenney D, Kumar A, Obregon-Perko V, Bar KJ, Saunders KO, Santra S, De Paris K, Tomaras GD, Chahroudi A, Permar SR, Amara RR, Fouda GG: Systematic assessment of antiviral potency, breadth, and synergy of triple broadly neutralizing antibody combinations against Simian-Human Immunodeficiency Viruses J Virol 95 (3): e01667-20,2020.
502 D Johnson Pavilion3610 Hamilton Walk
Patient appointments: 800-789-7366