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Katharine J. Bar, MD

Katharine J. Bar, MD Physician

Director, Virology Core, Penn Center for AIDS Research
Assistant Professor of Medicine
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Dr. Bar is a Penn Medicine employed physician.

Clinical Specialties

Specialty:

  • Infectious Diseases

Programs & Centers:

Board Certification:

  • Infectious Disease, 2009
  • Internal Medicine, 2005

Clinical Expertise:

  • C. Difficile (Clostridium Difficile Diarrhea)
  • Fever
  • Herpes Simplex Virus (HSV)
  • HIV and AIDS
  • HIV Co-Infection
  • Infections
  • Osteomyelitis
  • Sexually Transmitted Diseases (STD)

Description of Clinical Expertise

HIV care, general infectious disease care

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Iowa College of Medicine
Residency: Medical College of Virginia Hospitals
Fellowship: University of Alabama Hospital

Memberships

American College of Physicians, National HIV Vaccine Trials Network (HVTN) Research and Mentorship Program (RAMP) Scholar Grant Review Board, National Infectious Diseases Society of America, National National Institute for Allergy and Infectious Diseases Special Emphasis Panel Study Section ZRG1 AARR-K(56) "Optimization of Monoclonal Antibodies for Eliminating the HIV Reservoir", National

Hospital Affiliation

Dr. Bar is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

We study the basic mechanisms of transmission, pathogenesis and persistence in HIV and other chronic viral infections.

Current projects include:

1. The HIV transmission bottleneck and virus phenotype in injection drug users

2. The viral dynamics of rebound viremia upon cART interruption, both in the presence and absence of treatment and curative strategies

3. The neutralization properties of SIV challenge swarms and their transmitted/founder viruses

4. The genetic signatures of Herpes Simplex Virus immune escape from vaccine pressure


Lab Personnel:

Benjamin Scheinfeld, technician
D. Brenda Salantes, graduate student

Selected Publications:

Bar KJ, Sneller MC, Harrison LJ, Justement SJ, Overton ET, Petrone ME, Salantes BD, Seamon CA, Scheinfeld B, Kwan RW, Learn GH, Proschan MA, Kreider EF, Bazkova J, Bardsley M, Refsland EW, Messer M, Clarridge KE, Tustin NB, Madden PJ, Oden KS, O'Dell SJ, Jarocki B, Shiakolas AR, Tressler RL, Doria-Rose NA, Bailer RT, Ledgerwood JE, Capparelli EV, Lynch RM, Graham BS, Moir S, Koup RA, Mascola JR, Hoxie JA, Fauci AS, Tebas P, Chun T-W: Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption NEJM : 1-19,2016.

Salazar-Gonzalez JF, Salazar MG, Tully DC, Ogilvie CB, Learn GH, Allen TM, Heath SL, Goepfert P, Bar KJ: Use of dried blood spots to elucidate full-length transmitted/founder HIV-1 genomes Pathogens and Immunity 1 (1): 129-153,2016.

Lee FH, Mason R, Welles H, Learn GH, Keele BF, Roederer M, Bar KJ: Breakthrough virus neutralization resistance as a correlate of protection in a nonhuman primate heterologous SIV vaccine challenge study J Virol : 12388-400,2015.

Sterret S, Edlefsen PT, Learn GH, Haynes BF, Hahn BH, Shaw GM and Bar KJ: Low multiplicity of HIV-1 infection and no vaccine enhancement in VAX003 injection drug users Open Forum Infect Dis 1 (2): ofu056,2014.

Li H, Blair L, Chen Y, Learn G, Pfafferott K, John M, Bhattacharya T, Hahn BH, Mallal S, Shaw GM, Bar KJ: Molecular mechanisms of HIV-1 prophylaxis failure revealed by single genome sequencing J Inf Dis 208 (10): 1598-1603,2013.

Lopker M, Easlick J, Sterrett S, Decker JM, Barbian, Learn G, Keele BF, Robinson JE, Li H, Hahn BH, Shaw GM and Bar KJ: Heterogeneity in neutralization sensitivity of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock J Virol 87 (10): 5477-92,2013.

Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM, Goonetilleke N, Liu MK, Berg A, Hora B, Drinker MS, Eudailey J, Pickeral J, Moody MA, Ferrari G, McMichael A, Perelson AS, Shaw GM, Hahn BH, Haynes BF, Gao F: Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted founder/genome Retrovirology 9 (89): 1742-4690,2012.

Bar KJ, Tsao C, Iyer SS, Decker JM, Yang Y, Bonsignori M, Chen X, Hwang K, Montefiori DC, Liao H, Hraber P, Fischer W, Li H, Wang S, Sterett S, Keele BF, Ganusov VV, Perelson AS, Korber BT, Georgiev I, McLellan JS, Pavlicek JW, Gao F, Haynes BF, Hahn BH, Kwong PD, and Shaw GM: Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape PLoS Pathogens 8 (5): e1002721,2012.

Liao H, Chen X, Munshaw S, Zhang R, Marshall DJ, Vandergrift N, Whitesides JF, Lu X, Yu J, Hwang K, Gao F, Markowitz M, Heath SL, Bar KJ, Goepfert P, Montefiori D, Shaw GM, Alam M, Margolis D, Denny TN, Boyd SD, Marshal E, Egholm M, Simen B, Hanczaruk B, Fire AZ, Voss G, Kelsoe G, Tomaras G, Moody MA, Kepler TB, and Haynes BF: Initial Antibodies to Transmitted HIV-1 gp41 Env are Polyreactive and Have Characteristics of Origin from Mutated Memory B Cells J Exp Med 208 (11): 2237-49,2011.

Bar KJ, Li H, Chamberland A, Tremblay C, Routy JP, Grayson T, Sun C, Learn GH, Morgan CJ, Schumacher JE, Haynes BF, Keele BF, Hahn BH, Shaw GM: Wide Variation in the Multiplicity of HIV-1 Infection Among Injection Drug Users J Virol 84 (12): 6421-6427,2010.

Academic Contact Info

502 D Johnson Pavilion
3610 Hamilton Walk

Philadelphia, PA 19104-6073
Phone: (215) 573-8497
Fax: (215) 349-5111
Patient appointments: 800-789-PENN (7366)

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