Description of Research Expertise:
My research is focused on 1) developing strategies to mitigate breast cancer risk associated with metabolic syndrome by lifestyle modifications and by re-purposing some of the commonly prescribed medications to prevent breast cancer initiation and progression; 2) elucidating how novel immunotherapy such as CAR T therapy can induce epitope spreading and how combination therapy can unleash the anti-tumor effects of our own immune system; and 3) how we can use large data to enhance our understanding of tumor biology with the common goal of improving breast cancer outcomes.
Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, Magnani L, Calvo F: Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts Nature Communications : 2019 (Epub).
Williams AD, Li YR, So A, Steel L, Carrigan E, Ro V, Nguyen J, Tchou J: The impact of aspirin use on breast cancer subtype and clinical course Journal of Surgical Research 230 : 71-79,2018.
Williams AD, Reyes SA, Arlow RL, Tchou J, De La Cruz LM: Is age trumping genetic profiling in clinical practice? Relationship of chemotherapy recommendation and oncotype DX recurrence score in patients aged < 50 years versus ≥ 50 years, and trends over time Annals of Surgical Oncology 25 (10): 2875-2883,2018.
Williams AD, So A, Tchou J: Overall survival is similar between women who seek care at one or more institutions after diagnosis of operable breast cancer in the community Surgical Oncology 27 (3): 387-391,2018.
Modarressi T, Levine MA, Tchou J, Khan AN: Gestational gigantomastia complicated by PTHrP-mediated hypercalcemia Journal of Clinical Endocrinology & Metabolism 103 (9): 3124-3130,2018.
Yoon-Flannery K, DeStefano LM, De La Cruz LM, Fisher CS, Lin LY, Coffua LS, Mustafa RE, Sataloff DM, Tchou JC, Brooks AD: Quality of life and sexual well-being after nipple sparing mastectomy: A matched comparison of patients using the breast Q Journal of Surgical Oncology 118 (1): 238-242,2018.
So Alycia, De La Cruz Lucy M, Williams Austin D, Bahng Joseph, Liao Geraldine, McDonald Elizabeth S, Fisher Carla S, Czerniecki Brian J, Sataloff Dahlia, Tchou Julia: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience Journal of Surgical Oncology 117 (4): 558-566,2018.
Jakub James W, Peled Anne Warren, Gray Richard J, Greenup Rachel A, Kiluk John V, Sacchini Virgilio, McLaughlin Sarah A, Tchou Julia C, Vierkant Robert A, Degnim Amy C, Willey Shawna: Oncologic safety of prophylactic nipple-sparing mastectomy in a population with BRCA mutations: A multi-institutional study JAMA Surgery 153 (2): 123-129,2018.
Tchou Julia, Zhao Yangbing, Levine Bruce L, Zhang Paul J, Davis Megan M, Melenhorst Jan Joseph, Kulikovskaya Irina, Brennan Andrea L, Liu Xiaojun, Lacey Simon F, Posey Avery D, Williams Austin D, So Alycia, Conejo-Garcia Jose R, Plesa Gabriela, Young Regina M, McGettigan Shannon, Campbell Jean, Pierce Robert H, Matro Jennifer M, DeMichele Angela M, Clark Amy S, Cooper Laurence J, Schuchter Lynn M, Vonderheide Robert H, June Carl H: Safety and efficacy of intratumoral injections of chimeric antigen receptor (CAR) T cells in metastatic breast cancer Cancer Immunology Research 5 (12): 1152-1161,2017.
Williams AD, Payne KK, Posey AD Jr, Hill C, Conejo-Garcia J, June CH, Tchou J: Immunotherapy for breast cancer: Current and future strategies Current Surgical Reports 5 : pii: 31,2017.