Description of Research Expertise:
My research is focused on 1) developing strategies to mitigate breast cancer risk associated with metabolic syndrome by lifestyle modifications and by re-purposing some of the commonly prescribed medications to prevent breast cancer initiation and progression; 2) elucidating how novel immunotherapy such as CAR T therapy can induce epitope spreading and how combination therapy can unleash the anti-tumor effects of our own immune system; and 3) how we can use large data to enhance our understanding of tumor biology with the common goal of improving breast cancer outcomes.
Tchou Julia, Zhao Yangbing, Levine Bruce L, Zhang Paul J, Davis Megan M, Melenhorst Jan Joseph, Kulikovskaya Irina, Brennan Andrea L, Liu Xiaojun, Lacey Simon F, Posey Avery D, Williams Austin D, So Alycia, Conejo-Garcia Jose R, Plesa Gabriela, Young Regina M, McGettigan Shannon, Campbell Jean, Pierce Robert H, Matro Jennifer M, DeMichele Angela M, Clark Amy S, Cooper Laurence J, Schuchter Lynn M, Vonderheide Robert H, June Carl H: Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer. Cancer immunology research 5 (12): 1152-1161,2017.
So Alycia, De La Cruz Lucy M, Williams Austin D, Bahng Joseph, Liao Geraldine, McDonald Elizabeth S, Fisher Carla S, Czerniecki Brian J, Sataloff Dahlia, Tchou Julia: The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ-A single institution's experience. Journal of surgical oncology : 2017.
Mustafa Rose E, DeStefano Lauren M, Bahng Joey, Yoon-Flannery Kahyun, Fisher Carla S, Zhang Paul J, Tchou Julia, Czerniecki Brian J, De La Cruz Lucy M: Evaluating the Risk of Upstaging HER2-Positive DCIS to Invasive Breast Cancer. Annals of surgical oncology 24 (10): 2999-3003,2017.
Williams Austin D, So Alycia, Synnestvedt Marie, Tewksbury Colleen M, Kontos Despina, Hsiehm Meng-Kang, Pantalone Lauren, Conant Emily F, Schnall Mitchell, Dumon Kristoffel, Williams Noel, Tchou Julia: Mammographic breast density decreases after bariatric surgery. Breast cancer research and treatment 165 (3): 565-572,2017.
Nabet Barzin Y, Qiu Yu, Shabason Jacob E, Wu Tony J, Yoon Taewon, Kim Brian C, Benci Joseph L, DeMichele Angela M, Tchou Julia, Marcotrigiano Joseph, Minn Andy J: Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. Cell 170 (2): 352-366.e13,2017.
Cochran J M, Chung S H, Leproux A, Baker W B, Busch D R, DeMichele A M, Tchou J, Tromberg B J, Yodh A G: Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy. Physics in medicine and biology 62 (12): 4637-4653,2017.
Basta Marten N, Wu Liza C, Kanchwala Suhail K, Serletti Joseph M, Tchou Julia C, Kovach Stephen J, Fosnot Joshua, Fischer John P: Reliable prediction of postmastectomy lymphedema: The Risk Assessment Tool Evaluating Lymphedema. American journal of surgery 213 (6): 1125-1133.e1,2017.
Gershuni Victoria, Li Yun R, Williams Austin D, So Alycia, Steel Laura, Carrigan Elena, Tchou Julia: Breast cancer subtype distribution is different in normal weight, overweight, and obese women. Breast cancer research and treatment 163 (2): 375-381,2017.
Svoronos Nikolaos, Perales-Puchalt Alfredo, Allegrezza Michael J, Rutkowski Melanie R, Payne Kyle K, Tesone Amelia J, Nguyen Jenny M, Curiel Tyler J, Cadungog Mark G, Singhal Sunil, Eruslanov Evgeniy B, Zhang Paul, Tchou Julia, Zhang Rugang, Conejo-Garcia Jose R: Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer discovery 7 (1): 72-85,2017.
Perales-Puchalt Alfredo, Svoronos Nikolaos, Rutkowski Melanie R, Allegrezza Michael J, Tesone Amelia J, Payne Kyle K, Wickramasinghe Jayamanna, Nguyen Jenny M, O'Brien Shane W, Gumireddy Kiranmai, Huang Qihong, Cadungog Mark G, Connolly Denise C, Tchou Julia, Curiel Tyler J, Conejo-Garcia Jose R: Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target. Clinical cancer research : an official journal of the American Association for Cancer Research 23 (2): 441-453,2017.