Penn Medicine Provider
Hematology
Joshua Daniel Brandstadter, MD, PhD, MSc
Accepting new patients
Sees patients age 18 and up
Abramson Cancer Center Perelman 4th Floor West

About me

  • Director, Clinical Research, Center for Cytokine Storm Treatment & Laboratory
  • Instructor A of Medicine
  • Instructor A of Medicine (Hematology-Oncology)

Dr. Joshua Brandstadter is a physician-scientist who cares for patients with lymphoma and rare blood disorders, particularly Castleman Disease and histiocytic disorders. In addition to his clinical work, Dr. Brandstadter pursues laboratory-based translational research and serves as Director of Clinical Research for the Center for Cytokine Storm Treatment & Laboratory.

Education and training

  • Medical School: Duke University School of Medicine
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Brandstadter is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Sheila K Pierson, Joshua D Brandstadter, Drew Torigian, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat MD, Corey Casper, Amy Chadburn, Shanmuganathan Chandrakasan, Angela Dispenzieri, Alexander Fosså, Christian Hoffmann, Makoto Ide, Razelle Kurzrock, Sudipto Mukherjee, Sunita D Nasta, José-Tomás Navarro, Ariela Noy, Eric Oksenhendler, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Matthew J Streetly, Raymond Siu Ming Wong, Lu Zhang, Megan S Lim, Gordan Srkalovic, Frits van Rhee, David C Fajgenbaum Characterizing the heterogeneity of Castleman disease and oligocentric subtype: Findings from the ACCELERATE registry , Blood Advances: 2025


Anneka Allman, Brian T Gaudette, Samantha Kelly, Nagham Alouche, Léolène J Carrington, Eric Perkey, Joshua D Brandstadter, Riley Outen, Ashley Vanderbeck, Katlyn Lederer, Yeqiao Zhou, Robert B Faryabi, Tanner F Robertson, Janis K Burkhardt, Anastasia Tikhonova, Iannis Aifantis, Leonardo Scarpellino, Ute Koch, Freddy Radtke, Mechthild Lütge, Angelina De Martin, Burkhard Ludewig, Lena Tveriakhina, Achim Gossler, Lluc Mosteiro, Christian W Siebel, Daniela Gómez Atria, Sanjiv A Luther, David Allman, Ivan Maillard Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs , Immunity, 58(1): 2025


Brandstadter JD, Lutge M, Lim MS, Bagg A, Miller ID, Gonzalez MV, Austin B, Priore SF, Ludewig B, Fajgenbaum DC, Maillard I. Myofibroblast to T-Zone Reticular Cell Ratio Identifies Unicentric Castleman Disease Lymph Nodes , American Society of Hematology Annual Meeting, San Diego, CA.: 2024


Bustamante MS, Pierson SK, Ren Y, Bagg A, Brandstadter JD, Srkalovic G, Mango N, Alapat D, Lechowicz MJ, Li H, Van Rhee F, Lim MS, Fajgenbaum DC. Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease , Haematologica, 109: 2024,2196-2206


Shyamsundar S, Pierson SK, Connolly CM, Teles M, Segev DL, Werbel WA, van Rhee F, Casper C, Brandstadter JD, Noy A, Fajgenbaum DC. Castleman disease patients report mild COVID-19 symptoms and mount a humoral response to SARS-CoV-2 vaccination , Blood Neoplasia, 1(1): 2024,100002. doi: 10.1016/j.bneo.2024.100002.


Rubenstein AI, Pierson SK, Shyamsundar S, Bustamante MS, Gonzalez MV, Milller ID, Brandstadter JD, Mumau MD, Fajgenbaum DC. Immune-mediated thrombocytopenia and IL-6-mediated thrombocytosis observed in idiopathic multicentric Castleman disease , Br J Haematol, 204(3): 2024,921-930


Mango NA, Pierson SK, Sarmiento Bustamante M, Brandstadter JD, van Rhee F, Fajgenbaum DC. Siltuximab administration results in spurious IL-6 elevation in peripheral blood , Am J Hematol, 99(1): 2024,E15-E18.


Pierson SK, Lim MS, Srkalovic G, Brandstadter JD, Sarmiento Bustamante M, Shyamsundar S, Mango N, Lavery C, Austin B, Alapat D, Lechowicz MJ, Bagg A, Li H, Casper C, van Rhee F, Fajgenbaum DC. Treatment Consistent with Idiopathic Multicentric Castleman Disease Guidelines is Associated with Improved Outcomes , Blood Adv, 7(21): 2023,6652-6664


Sarmiento Bustamante M, Shyamsundar S, Coren FR, Bagg A, Srkalovic G, Alapat D, van Rhee F, Lim MS, Lechowicz MJ, Brandstadter JD, Pierson SK, Fajgenbaum DC. Ongoing symptoms following complete surgical excision in unicentric Castleman disease , Am J Hematol, 98(11): 2023,E334-E337.


Brandstadter JD, Outen R, Maillard I. Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity , J Clin Invest, 133(15): 2023,e172251


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