Description of Research Expertise

Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.

Selected Publications

Horwitz A, McCarthy K, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Domeier RM, Rathlev NK, Sergot P, Sanchez LD, Bruce SE, Joormann J, Harte SE, Koenen KC, McLean SA, Sen S.: Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning J Anxiety Disord 104 : 102876,2024.

Bele P, Thaploo A, Coons M, Culkin MC, Santos P, Martinez-Quinones P, Georges AP, Anderson E, Browne KD, Jacovides C, Kaplan LJ, Meaney DF, Smith DH, Pascual JL.: Daily quetiapine after severe TBI improves learning and memory J Trauma Acute Care Surg : 2024.

Haering, S., Seligowski, A. V., Linnstaedt, S. D., Michopoulos, V., House, S. L., Beaudoin, F. L., An, X., Neylan, T. C., Clifford, G. D., Germine, L. T., Rauch, S. L., Haran, J. P., Storrow, A. B., Lewandowski, C., Musey, P. I., Jr., Hendry, P. L., Sheikh, S., Jones, C. W., Punches, B. E., Swor, R. A., Gentile, N. T., Hudak, L. A., Pascual, J. L., Seamon, M. J., Pearson, C., Peak, D. A., Merchant, R. C., Domeier, R. M., Rathlev, N. K., O'Neil, B. J., Sanchez, L. D., Bruce, S. E., Harte, S. E., McLean, S. A., Kessler, R. C., Koenen, K. C., Stevens, J. S., Powers, A.: Sex-dependent differences in vulnerability to early risk factors for posttraumatic stress disorder: results from the AURORA study Psychol Med : 1-11,2024.

Vemu R, Yane TK, Glova GS, Paglia PL, Okyan K, Meaney DF, Chreiman K, Kaplan LJ, Pascual JL.: A simple engineering alteration to IO access device electronics can lead to improved placement accuracy confirmation J Trauma Acute Care Surg 96 : e28-e32,2024.

Culkin MC, Bele P, Georges AP, Santos P, Niziolek G, Kaplan LJ, Smith DH, Pascual JL.: Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood-Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study Neurocrit Care : 2024.

Garrison-Desany HM, Meyers JL, Linnstaedt SD, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Jovanovic T, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Gentile NT, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Bruce SE, Joormann J, Harte SE, McLean SA, Koenen KC, Denckla CA.: Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk Front Psychiatry 15 : 1249382,2024.

Feather CB, Rehrig S, Allen R, Barth N, Kugler EM, Cullinane DC, Falank CR, Bhattacharya B, Maung AA, Seng S, Ratnasekera A, Bass GA, Butler D, Pascual JL, Srikureja D, Winicki N, Lynde J, Nowak B, Azar F, Thompson LA, Nahmias J, Manasa M, Tesoriero R, Kumar SB, Collom M, Kincaid M, Sperwer K, Santos AP, Klune JR, Turcotte J.: To close or not to close? Wound management in emergent colorectal surgery, an EAST Multicenter prospective cohort study J Trauma Acute Care Surg : 2024.

Borst B, Jovanovic T, House SL, Bruce SE, Harnett NG, Roeckner AR, Ely TD, Lebois LAM, Young D, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Sanchez LD, Harte SE, Koenen KC, Kessler RC, McLean SA, Ressler KJ, Stevens JS, van Rooij SJH.: Sex differences in response inhibition-related neural predictors of PTSD in recent trauma-exposed civilians Biol Psychiatry Cogn Neurosci Neuroimaging : 2024.

Gummadi, Sriharsha, Pascual L, Jose L.: Postoperative Neurologic Complications in the Older Adult Current Geriatrics Reports 13 (2): 61-69,2024.

Hinojosa CA, Liew A, An X, Stevens JS, Basu A, van Rooij SJH, House SL, Beaudoin FL, Zeng D, Neylan TC, Clifford GD, Jovanovic T, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Datner EM, Chang AM, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, Sergot P, Sanchez LD, Bruce SE, Miller MW, Pietrzak RH, Joormann J, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Ressler KJ, Fani N.: Associations of alcohol and cannabis use with change in posttraumatic stress disorder and depression symptoms over time in recently trauma-exposed individuals Psychol Med : 2024.

Academic Contact Information

Division of Trauma & Surgical Critical Care
Penn Presbyterian Medical Center
51 North 39th St., MOB 1st Fl., Ste. 120, Rm. 108
Philadelphia, PA 19104
Phone: 215-662-7323
Patient appointments: 800-789-7366