Description of Research Expertise:
Jose Pascual is a clinical surgeon specialized in trauma and critical care who has a special interest in shock and head injury. His research interests are shared in basic science research where he evaluates, in vivo, through intravital microscopy the real time microcirculation of pia on live rodent brains. He seeks to learn how a variety of insults including head injury and shock affect the microcirculation and how different management strategies influence these changes. This basic science work is translated into several clinical projects both retrospective and prospective evaluating the effects of different osmotherapeutic agents in traumatic brain injured patients as well as the immunemodulating effects of different resuscitation fluids in different forms of shock.
Moore S, Weiss B, Pascual JL, Kaplan LJ.: Management of Acute Respiratory Failure in the Patient with Sepsis or Septic Shock. Surg Infect (Larchmt). : 2018.
Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson VE, Kaplan L, Marks J, Smith DH, Pascual JL.: Early Non-anticoagulant Desulfated Heparin After TBI: Reduced Brain Edema and Leukocyte Mobilization is Associated with Improved Watermaze Learning Ability Weeks After Injury. J Trauma Acute Care Surg : 2018.
Nagata K, Suto Y, Cognetti J, Browne KD, Kumasaka K, Johnson V, Kaplan L, Marks JA, Smith DH, Pascual JL.: Non-Anticoagulant desulfated heparin acutely reduces leukocyte mobilization and brain edema and improves watermaze learning ability weeks after traumatic brain injury. Podium presentation at the 76th Annual Meeting of the American Association for the Surgery of Trauma, Baltimore, MD. : 2017.
Sherma A, Sinha S, Oselkin M, Pascual J, Schuster J: External carotid pseudoaneurysm due to wound vacuum placement after self-inflicted shotgun blast to face. Podium at 3rd Annual Critical Care Spectacular Case Presentation Competition, Philadelphia Drinker Society,Philadelphia, PA : 2017.
Resnick S, Seamon MJ, Holena DH, Pascual JL, Reilly PM, Martin ND.: Early Declaration of Death by Neurologic Criteria Results in Greater Organ Donor Potential J Surg Res : 2017.
Pascual JL, Cannon J.: Hemorrhagic Shock: Recognition, Pathophysiology and Management. Nova Science Publishers, Inc., New York, NY. : 2017.
J, Gray J, Miano T, Redline G, Teufel H, Collins T, Pascual-Lopez J, Sylvia M, Martin ND: Pain, Agitation, and Delirium Guidelines: Interprofessional Perspectives to Translate the Evidence. Dimens Crit Care Nurs : 36(3):164-173.,2017.
Nunn AM, Hatchimonji JS, Holena DN, Seamon MJ, Smith BP, Kaplan LJ, Martin ND, Reilly PM, Schwab CW, Pascual JL: Boarding ICU patients: Are our rounding practices subpar? Am J Surg
Nagata K, Browne KD, Suto Y, Kumasaka K, Cognetti J, Johnson VE, Marks J, Smith DH, Pascual JL.: Early Heparin Administration After TBI: Prolonged Cognitive Recovery Associated With Reduced Cerebral Edema and Neutrophil Sequestration. J Trauma Acute Care Surg. 2017 May 22. doi: 10.1097/TA.0000000000001590 J Trauma Acute Care Surg. : 2017.
Kuo LE, Kaufman E, Hoffman RL, Pascual JL, Martin ND, Kelz RR, Holena DN.: Failure-to-rescue after injury is associated with preventability: The results of mortality panel review of failure-to-rescue cases in trauma.
PMID: 27788924 Surgery. 2017 Mar;161(3):782-790. doi: 10.1016/j.surg.2016.08.017. Epub 2016 Oct 25. : 2017.