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Sees patients age 18 and up
Sees patients age 18 and up
Perelman Center for Advanced Medicine
South Pavilion, 1st Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
The Miner laboratory studies the intersection of autoimmunity and antiviral immunity. This includes studies of rare rheumatic diseases caused by mutations in genes that regulate immune responses to viruses, such as the TREX1, cGAS, STING, RIG-I, and STAT1 genes. The Miner laboratory is also developing novel therapeutics for rare diseases, and is conducting whole-genome CRISPR/Cas9 screens to discover novel regulators of these pathways.Examples of diseases studied in the Miner laboratory include: * Retinal vasculopathy with cerebral leukoencephalopathy (RVCL), caused by mutations in TREX1. * STING-associated vasculopathy with onset in infancy (SAVI), caused by mutations in STING. * Chronic mucocutaneous candidiasis (CMC), caused by mutations in STAT1* Monogenic systemic lupus erythematosus (SLE), caused by mutations in NF-kB signaling pathways* Hemophagocytic lymphohistiocytosis (HLH), caused by mutations in viral RNA-sensing pathways* Viral infections (e.g., models of chikungunya viral arthritis, and models of Zika virus, West Nile virus, bunyavirus, coronavirus, and herpesvirus pathogenesis).
Platt DJ, Lawrence D, Qian W, Rodger R, Schriefer L, Miner CA, Menos AM, Kennedy EA, Peterson ST, Stinson WA, Baldridge MT, Miner, JJ: Transferrable protection by gut microbes against STING-associated lung disease Cell Rep. 35 (6): 109133,2021.
Miner JJ, Platt DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA, Apte RS.: "HSV-1 and Zika virus but not SARS-CoV-2 replicate in the human cornea and are restricted by corneal type III interferon." Cell Rep. 33 (5): 108339,2020.
Ford AL, Chin V, Fellah S, Binkley MM, Bodin A, Balasetti V, Taiwo Y, Kang P, Lin D, Jen J, Grand G, Bogacki M, Liszewski K, Hourcade D, Chen Y, Hassenstab J, Lee JM, An H, Miner JJ, Atkinson JP.: "Lesion evolution and neurodegeneration in RVCL-S, a monogenic microvasculopathy." Neurology. 95 (14): 1918-31,2020.
Bennion BG, Croft CA, Ai TL, Qian W, Menos AM, Miner CA, Fremond ML, Doisne JM, Andhey PS, Platt DJ, Bando JK, Wang ER, Luksch H, Molina TJ, Robison EDO, Artyomov MN, Rosen-Wolff A, Colonna M, Rieux-Laucat F, Di Santo JP, Neven B, Miner JJ.: "STING gain-of-function disrupts lymph node organogenesis and innate lymphoid cell development in mice." Cell Rep. 31 (11): 107771,2020.
Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ.: "STING-associated lung disease in mice relies on T cells but not type I interferon" J Allergy Clin Immunol. 144 (1): 154-266,2019.
Bennion BG, Ingle H, Ai TL, Miner CA, Platt DJ, Smith AM, Baldridge MT, Miner JJ.: "A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice" J Virol. 93 (4): e01806-18,2019.
Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ.: "A human STAT1 gain-of-function mutation impairs CD8+ T cell responses against gammaherpesvirus-68." J Virol. 93 (19): 307-19,2019.
Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ.: "Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice." Sci Transl Med. 426 (10): 7090,2018.
Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Platt DJ, Yan N, Miner JJ.: "STING-associated vasculopathy develops independently of IRF3 in mice" J Exp Med. 214 (11): 3279-92,2017.
Miner JJ, Cao, B, Govero, J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS: "Zika virus infection during pregnancy in mice causes placental damage and fetal demise." Cell. 165 (5): 1081-91,2016.
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