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Jonathan P. Katz, MD

Jonathan P. Katz, MD Physician

Associate Professor of Medicine

Dr. Katz is a Penn Medicine employed physician.

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Clinical Specialties

Specialty:

  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 1998

Clinical Expertise:

  • Endoscopy

Practice Locations and Appointments

  • Penn Gastroenterology

    Perelman Center for Advanced Medicine South Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Chicago School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

AGA Augustyn Award Review Panel, National AGA Funderburg Award Review Panel , National AGA Institute, Research Awards Panel, National AGA Microbiome Junior Investigator Research Award Review Panel , National AGA Rome Foundation Pilot Award Review Panel, National AGA-Broad Student Research Fellowship Review Panel, National AGA-Elsevier Pilot/Gut Microbiome Pilot Award Review Panel, National American Association for Cancer Research, International American Association for the Advancement of Science, National American Gastroenterological Association, National American Gastroenterological Association, Trainee and Young GI Policy Council, National Cancer Research UK, International DDW Abstract Review Committee, International Gastroenterology Research Group, National Health Research Board (HRB), Ireland, International Medical Research Council (MRC), Great Britain, International Medical Research Council (MRC), Molecular and Cellular Medicine Board (MCMB), Great Britain, International Medical Research Council (MRC), Molecular and Cellular Medicine Board (MCMB), International Molecular and Cellular Oncology P01 Special Emphasis Panel, National NCI Cellular and Molecular Biology P01 Cluster Grant Review Panel, National NCI Provocative Question 6 Special Emphasis Panel, National NIDDK DDK-C Study Section, National NIDDK P01 Special Emphasis Panel, National NIDDK Silvio O. Conte Digestive Diseases Research Core Centers P30 Special Emphasis Panel, National NIDDK Silvio O. Conte Digestive Diseases Research Core Centers P30 Special Emphasis Panel, National NIH Gastrointestinal Mucosal Pathobiology (GMPB) Study Section, National NIH OTC K04 CDP member conflict Special Emphasis Panel , National NIH ZRG1 CB-J (30) Study Section, National NIH ZRG1 DKUS C Special Emphasis Panel, National NIH ZRG1 DKUS-H (02) M Review Panel, National Pilot Projects, New England Medical Center, Center for Gastroenterology Research on Absorptive and Secretory Processes (GRASP), National Pilot Projects, University of Pennsylvania, Center for Molecular Studies in Digestive and Liver Diseases, Local Wellcome Trust, International

Hospital Affiliation

Dr. Katz is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Radnor: Has privileges to perform procedures.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Research Interests
Transcriptional regulation
Epithelial homeostasis
Gastrointestinal carcinogenesis

Key words: gastrointestinal cancer, Krüppel-like factors, proliferation, differentiation

Description of Research
Our research is focused broadly on functional analyses of gastrointestinal epithelial proliferation, differentiation, and carcinogenesis, using both in vivo and in vitro approaches, including murine models and innovative three-dimensional tissue culture systems. To dissect the critical pathways regulating gastrointestinal epithelial homeostasis and disease, we have focused predominantly on the roles of two critical transcriptional regulators in the Krüppel-like factor (KLF) family of proteins, KLF4 and KLF5, with a particular focus on the biology of the squamous-lined esophagus. Both KLF4 and KLF5 have been implicated in key cellular process such differentiation, inflammation, stemness, and carcinogenesis in a number of tissues and cell types. Current areas of investigation in our laboratory include the functional interactions between KLF4 and the non-canonical Wnt ligand WNT5A and between KLF5 and the tumor suppressor p53. Overall, these studies seek to define the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis.

Rotation Projects
Several rotation projects are available in the laboratory based upon applicant interests. Please contact Dr. Katz directly to discuss potential projects.

Lab personnel:
Jonathan Katz, MD – Principal Investigator
Yizeng Yang, MD, PhD - Senior Research Investigator
Khvaramze Shaverdashvili, MD, PhD - Postdoctoral Fellow
Daniel Weinblatt - Research Specialist
Jinshen Wang, MD - Visiting Scholar
Divya Rao - Undergraduate Student

Administrative Assistant:
Marielle Kent
Phone: 215-898-0850
Email: hsharpe@mail.med.upenn.edu

Selected Publications:

Tetreault, M.P., Yang, Y., Katz, J.P: Krüppel-like factors in cancer. Nature Reviews Cancer 13 (10): 701-13,2013.

Tarapore, R.S., Yang, Y., Katz, J.P.: Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival. Neoplasia 15 (5): 472-80,2013.

Yang, Y., Tarapore, R.S., Jarmel, M.H., Tetreault, M.P., Katz, J.P.: p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle 11 (21): 2012.

Tetreault, M.P., Alrabaa, R., McGeehan, M., Katz, J.P.: Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One 7 (5): e38338,2012.

Yang, Y., Nakagawa, H., Tetreault, M.P., Billig, J., Victor, N., Goyal, A., Sepulveda, A.R., Katz, J.P.: Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Research 71 (20): 6475-84,2011.

Tetreault, M.P., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Tobias, J.W., Katz, J.P.: Esophageal squamous cell dysplasia and delayed differentiation with deletion of Krüppel-like factor 4 in murine esophagus. Gastroenterology 139 (1): 171-81.e9,2010.

Tetreault, M.P., Wang, M.L., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Katz, J.P.: Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology 139 (6): 2124-2134.e9,2010.

Yang, Y., Tetreault, M.P., Yermolina, Y., Goldstein, B.G., Katz, J.P.: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. Journal of Biological Chemistry 283 : 18812-20,2008.

Yang, Y., Goldstein, B.G., Nakagawa, H., Katz, J.P.: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 21 : 543-50,2007.

Yang, Y., Goldstein, B.G., Chao, H., Katz, J.P.: KLF4 and KLF5 regulate proliferation, apoptosis, and invasion in esophageal cancer cells. Cancer Biology and Therapy 4 : 1216-21,2005.

View all publications

Academic Contact Info

421 Curie Boulevard
913 Biomedical Research Building II/III

Philadelphia, PA 19104-4863
Phone: 215-746-7780
Fax: 215-573-2024
Patient appointments: 800-789-7366 (PENN)

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