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John T. Seykora, MD

John T. Seykora, MD Physician

Associate Professor of Dermatology
Associate Professor of Pathology and Laboratory Medicine

Dr. Seykora is a Penn Medicine employed physician.

About Dr. John T. Seykora

Dr. Seykora reads dermatopathology at HUP, but does not schedule appointments with patients.

Clinical Specialties

Specialty:

  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology - Dermatopathology, 1998
  • Pathology - Anatomic Pathology, 1997

Clinical Expertise:

  • Dermatopathology
  • Diagnosis/Second Opinion
  • Immunodermatology
  • Lesions
  • Oral Lesions
  • Precancerous Lesions
  • Skin Biopsy
  • Skin Cancer

Description of Clinical Expertise

Dermatopathology
1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Practice Locations and Appointments

  • Penn Dermatology

    Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Weill Medical College of Cornell University
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Academy of Dermatology, National American Society of Dermatopathology, National Dermatology Foundation, National NIH ACTS/CE/SEP Study Section, National Pennsylvania Regional Society of Dermatopathologists, Local Philadelphia College of Physicians, Local Philadelphia Dermatological Society, Local Signum Pharmaceuticals, Monmouth Junction, New Jersey, National Society of Investigative Dermatology, National Society of Investigative Dermatology, National

Hospital Affiliation

Dr. Seykora is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Selected Publications:

Billings, PC, Sanzari, JK, Kennedy, AR, Cengel, KA and Seykora, JT: Quantitation of skin pigmentation using open source image analysis software. Pending revisions Experimental Dermatology : 2014.

Wong, WJ, Richardson, T, Seykora, JT, Cotsarelis, G and Simon, MC: Hypoxia inducible factors regulate filaggrin expression and epidermal barrier function. Pending revisions, JID : 2014.

Gober MD, Bashir HM, Seykora JT: Reconstructing skin cancers using animal models. Cancer Metastasis Rev. 32 : 123-128,2013.

Sanzari, JK, Billings, PC, Diffenderfer, ES, Gridley, DS, Seykora, JT, Kennedy, AR and Cengel, KA: Acute Biological Effects of Solar Particle Radiation on Skin Using a Porcine Model. Radiat Res. : 2013.

Kouno M, Lin C, Schechter N, Siegel D, Yang X, Seykora JT, and Stanley, J: Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody. J Invest Dermatol 133 : 2212-20,2013.

Chehoud, C., Rafail, S., Tyldsley, A., Seykora, J., Lambris, J. and Grice, E.: Complement modulates the cutaneous microbiome and inflammatory milieu. PNAS 110 : 15061-6,2013.

Ratushny, V., Gober, M., Hick, R., Ridky, T., and Seykora, J.: “From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.” J Clin Invest. 122 (2): 464–472,2012.

Teta, M., Choi, YS, Okegbe, T., Wong, G., Tam, O., Chong, M., Seykora, J., Nagy, A., Littman, D., Andl, T., and Millar, S.: “Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.” Development 139 : 1405-16,2012.

Wanat KA, Holler PD, Dentchev T, Simbirl K, Robertson E, Seykora JT, Rosenbach M: Viral-Associated Trichodysplasia: characterization of a novel polyoma virus infection with therapeutic insights. Archives of Dermatology 148 : 219-23,2012.

Chu, E Y, Wanat, K A, Miller, C J, Amaravadi, R K, Fecher, L A, Brose, M S, McGettigan, S, Giles, L R, Schuchter, L M, Seykora, J T, Rosenbach, M: Diverse cutaneous side effects associated with BRAF inhibitor therapy: A clinicopathologic study. J Am Acad Dermatol 67 : 1265-72,2012.

Academic Contact Info

Department of Dermatology
421 Curie Blvd
Room 1011 BRB II/III

Philadelphia, PA 19104-6142
Phone: (215) 898-0170
Fax: (215) 573-2143
Patient appointments: 800-789-PENN (7366)

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