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John P. Reilly, MD, MSCE

John P. Reilly, MD, MSCE Physician

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania

Dr. Reilly is employed by Penn Medicine.

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Clinical Specialties


  • Pulmonary Medicine

Programs & Centers:

Board Certification:

  • Critical Care Medicine, 2014
  • Internal Medicine, 2010
  • Pulmonary Disease, 2012

Clinical Expertise:

  • Acute Respiratory Distress Syndrome (ARDS)
  • Needle Procedure
  • Pulmonary Embolism (Pulmonary Embolus)
  • Respiratory Failure
  • Sepsis (Septicemia)

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: New York University School of Medicine
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: Hospital of the University of Pennsylvania


American College of Chest Physicians, National American Thoracic Society, National Society of Critical Care Medicine, National

Hospital Affiliation

Dr. Reilly is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Dr. Reilly conducts translational patient-oriented research in critical care medicine aimed at understanding clinical and molecular risk factors for sepsis and the acute respiratory distress syndrome (ARDS). He collaborates with other members of the faculty to conduct prospective cohort studies of critically ill patients with severe sepsis and acute trauma. Currently, his research focuses on understanding a novel association between the ABO blood group and risk of organ dysfunction (i.e. ARDS and acute kidney injury) in the setting of trauma and severe sepsis. His ultimate goal is to provide mechanistic insights into critical illness that can be translated to improved care for patients suffering from sepsis and ARDS.

Selected Publications:

Reilly JP, Christie JD: Is it possible to prevent ARDS? Journal of the American Medical Association (JAMA). 315 (22): 2403-2405,2016.

Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MGS: The ABO histo-blood group and acute kidney injury in critically ill trauma and sepsis patients. Clinical Journal of the American Society of Nephrology. 10 (11): 1911-1920,2015.

Reilly JP, Christie JD: Primed for injury: cigarette smokers and ARDS. Critical Care Medicine. 43 (9): 2015-2016,2015.

Zhong M, Zhang H, Reilly JP, Christie JD, Ishihara M, Kumagai T, Azadi P, Reilly MP: ABO blood group as a model for platelet glycan modification in arterial thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 35 (7): 1570-1578,2015.

Reilly JP, Christie JD: Acute Lung Injury and Acute Respiratory Distress Syndrome: Clinical Features, Management, and Outcomes. Fishman's Pulmonary Diseases and Disorders, Fifth Edition. : 2172-2195,2015.

Reilly JP, Christie JD: Linking genetics to ARDS pathogenesis: the role of the platelet. Chest. 147 (3): 585-586,2015.

Qing DY, Conegliano D, Shashaty MG, Seo J, Reilly JP, Worthen GS, Huh D, Meyer NJ, Mangalmurti NS: RBCs induce necroptosis of lung endothelial cells and increase susceptibility to lung inflammation. American Journal of Respiratory and Critical Care Medicine. 190 (11): 1243-1254,2014.

Reid MJA, Merlin J, Biller N, Lyon SM, Reilly JP, Dacso M, Friedman HM: Reducing risk and enhancing education: US medical students on global health electives. American Journal of Infection Control. 42 (12): 1319-1321,2014.

Reilly JP, Meyer NJ: Pattern recognition in the acute respiratory distress syndrome: a critical first step towards personalized therapy. Lancet Respiratory Medicine. 2 (8): 594-595,2014.

Shashaty MGS, Kalkan E, Bellamy SL, Reilly JP, Holena DN, Cummins K, Lanken PN, Feldman HI, Reilly MP, Udupa JK, Christie JD: Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients. Critical Care Medicine. 42 (7): 1619-1628,2014.

Reilly JP, Bellamy S, Shashaty MGS, Gallop R, Meyer NJ, Lanken PN, Kaplan S, Holena DN, May AK, Ware LB, Christie JD: Heterogeneous phenotypes of the acute respiratory distress syndrome after major trauma. Annals of the American Thoracic Society. 11 (5): 728-736,2014.

Reilly JP, Meyer NJ, Shashaty MGS, Feng R, Lanken PN, Gallop R, Kaplan S, Herlim M, Oz NL, Hiciano I, Campbell A, Holena D, Reilly MP, Christie JD: ABO blood type A is associated with increased risk of acute respiratory distress syndrome in whites following both major trauma and severe sepsis. Chest. 145 (4): 753-761,2014.

Academic Contact Info

Hospital of the University of Pennyslvania
5011 Gibson Building
3400 Spruce Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)