Description of Research Expertise:
1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.
2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.
3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.
4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)
Bauman Brittany, Mick Rosemarie, Martinez Eileen, Lawless Theresa M, Zinck Lindsey, Sinclair Paige, Fuhrer Mary, O'Hara Mark, Schneider Charles J, O'Dwyer Peter, Plastaras John, Teitelbaum Ursina, Reiss Kim A: Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial. Journal of the National Comprehensive Cancer Network : JNCCN 17 (4): 358-364,2019.
Demissei Biniyam G, Freedman Gary, Feigenberg Steven J, Plastaras John P, Maity Amit, Smith Amanda M, McDonald Caitlin, Sheline Karyn, Simone Charles B, Lin Lilie L, Carver Joseph R, Liu Peter, Zhang Liyong, Bekelman Justin E, Ky Bonnie: Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma. International journal of radiation oncology, biology, physics 103 (4): 851-860,2019.
Men Kuo, Boimel Pamela, Janopaul-Naylor James, Cheng Chingyun, Zhong Haoyu, Huang Mi, Geng Huaizhi, Fan Yong, Plastaras John P, Ben-Josef Edgar, Xiao Ying: A study of positioning orientation effect on segmentation accuracy using convolutional neural networks for rectal cancer. Journal of applied clinical medical physics 20 (1): 110-117,2019.
Men Kuo, Geng Huaizhi, Cheng Chingyun, Zhong Haoyu, Huang Mi, Fan Yong, Plastaras John P, Lin Alexander, Xiao Ying: Technical Note: More accurate and efficient segmentation of organs-at-risk in radiotherapy with convolutional neural networks cascades. Medical physics 46 (1): 286-292,2019.
R. Rengan, R. Mick, D.A. Pryma, L. L. Lin, J. Christodouleas, J.P. Plastaras, C. B. Simone II, A.K. Gupta, T. L. Evans, J. P. Stevenson, C.J. Langer, J. Kucharczuk, J. Friedberg, S. Lam, D. Patsch, S.M. Hahn, A. Maity: A Phase I/II Trial of the HIV Protease Inhibitor Nelfinavir with Concurrent Chemoradiotherapy (CT-RT) for Unresectable Stage IIIA/IIIB Non-Small Cell Lung Cancer (NSCLC): Long Term Clinical Outcomes JAMA Oncology : 2019.
Wo JY, Plastaras JP, Metz JM, Jiang W, Yeap BY, Drapek LC, Baglini C, Ryan DP, Murphy JE, Kwak E, Parikh A, Allen J, Blaszkowsky L, Delaney T, Ben-Josef E, Hong TS: Pencil Beam Scanning Proton Beam Chemoradiotherapy with 5-Fluorouracil and Mitomycin-C for Definitive Treatment of Carcinoma of the Anal Canal: A Multi-institutional Pilot Feasibility Study International Journal of Radiation Oncology, Biology, Physics accepted : 2019.
J Jones, M Alonso-Basanta, A Maity, J Plastaras, S Zhu, W T Arscott: Acute neurologic toxicity of palliative radiotherapy for brain metastases in patients receiving immune checkpoint blockade Neuro-Oncology Practice : 2018.
Men Kuo, Boimel Pamela, Janopaul-Naylor James, Zhong Haoyu, Huang Mi, Geng Huaizhi, Cheng Chingyun, Fan Yong, Plastaras John P, Ben-Josef Edgar, Xiao Ying: Cascaded atrous convolution and spatial pyramid pooling for more accurate tumor target segmentation for rectal cancer radiotherapy. Physics in medicine and biology 63 (18): 185016,2018.
H. Ahmed, A. Pantel, J. Metz, J.P. Plastaras, and M. Farwell: FDG-Avid Focal Liver Reaction from Proton Therapy in a Patient with Primary Esophageal Adenocarcinoma Journal Clinical Nuclear Medicine 43 (5): e139-e141,2018.
Regine William F, Winter Kathryn, Abrams Ross A, Safran Howard, Kessel Ivan L, Chen Yuhchyau, Fugazzi James A, Donnelly Eric D, DiPetrillo Thomas A, Narayan Samir, Plastaras John P, Gaur Rakesh, Delouya Guila, Suh John H, Meyer Joshua E, Haddock Michael G, Didolkar Mukund S, Padula Gilbert D A, Johnson David, Hoffman John P, Crane Christopher H: Postresection CA19-9 and margin status as predictors of recurrence after adjuvant treatment for pancreatic carcinoma: Analysis of NRG oncology RTOG trial 9704. Advances in radiation oncology 3 (2): 154-162,2018.