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John P. Plastaras, MD

John P. Plastaras, MD Physician

Chief, Gastrointestinal/Lymphoma Service, Radiation Oncology Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Dr. Plastaras is employed by Penn Medicine.

About Dr. John P. Plastaras

Recognized by Best Doctors in America 2015, 2016

Recognized in Philadelphia magazine's May 2019 Top Docs issue

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Hematology
  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2008

Clinical Expertise:

  • Abdominal Chemotherapy
  • Acute Lymphocytic Leukemia
  • Acute Myelogenous Leukemia
  • Acute Promyelocytic Leukemia
  • Adult T-Cell Leukemia
  • Adult T-Cell Lymphoma
  • AIDS Related Malignancies
  • Amyloidosis
  • Anaplastic Large Cell Lymphoma
  • Blood Cancer
  • Bone Marrow Biopsy
  • Bone Marrow Failure Syndromes
  • Burkitt Lymphoma
  • Cancer During Pregnancy
  • Castleman Disease
  • Chronic Lymphocytic Leukemia
  • Chronic Myelocytic Leukemia
  • Chronic Myelomonocytic Leukemia
  • CNS Lymphoma
  • Colon Tumors
  • Cutaneous Lymphoma
  • Eosinophilic Granuloma
  • Erdheim-Chester Disease
  • Essential Thrombocytosis
  • Family History of Colon Cancer
  • Graft Versus Host Disease
  • Hairy Cell Leukemia
  • Hematologic Malignancies
  • Histiocytosis
  • Hodgkin Lymphoma
  • Intraocular Lymphoma
  • Large Granular Lymphocytic Leukemia
  • Leukemia
  • Light Chain Disorders
  • Lymphoma
  • Marginal Zone Lymphoma
  • Mediastinal Lymphoma
  • Monoclonal Gammopathy of Undetermined Significance
  • Mucosa-Associated Lymphoid Tissue Lymphoma
  • Multiple Myeloma
  • Myelodysplastic Syndromes (MDS)
  • Myeloproliferative Neoplasms (MPN)
  • Non-Hodgkin Lymphoma
  • Peripheral T-Cell Lymphoma
  • Plasma Cell Dyscrasia
  • POEMS Syndrome
  • Polycythemia
  • Primary Myelofibrosis
  • Prolymphocytic Leukemia
  • Radiation Toxicity
  • Refractory Anemia With Excess Blasts
  • Sezary Syndrome
  • Transformed Lymphoma
  • Waldenstrom Macroglobulinemia (WM)
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Vanderbilt University
Residency: Memorial Sloan-Kettering Cancer Center
Residency: Hospital of the University of Pennsylvania


American Board of Radiology, National American Society for Radiation Oncology (ASTRO), National International Lymphoma Radiation Oncology Group (ILROG), International

Hospital Affiliation

Dr. Plastaras is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" ( Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" ( Identifier: NCT01449864)

Selected Publications:

A. Wojcieszynski, C. L. Hallemeier, J. B. Ashman, M. G. Haddock, J. Metz, J. Plastaras, E. Ben-Josef, V. K. Reddy, A. Barsky: Proton beam re-irradiation for gastrointestinal malignancies: a systematic review Journal of Gastrointestinal Oncology : 2019.

Bauman Brittany, Mick Rosemarie, Martinez Eileen, Lawless Theresa M, Zinck Lindsey, Sinclair Paige, Fuhrer Mary, O'Hara Mark, Schneider Charles J, O'Dwyer Peter, Plastaras John, Teitelbaum Ursina, Reiss Kim A: Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial. Journal of the National Comprehensive Cancer Network : JNCCN 17 (4): 358-364,2019.

Demissei Biniyam G, Freedman Gary, Feigenberg Steven J, Plastaras John P, Maity Amit, Smith Amanda M, McDonald Caitlin, Sheline Karyn, Simone Charles B, Lin Lilie L, Carver Joseph R, Liu Peter, Zhang Liyong, Bekelman Justin E, Ky Bonnie: Early Changes in Cardiovascular Biomarkers with Contemporary Thoracic Radiation Therapy for Breast Cancer, Lung Cancer, and Lymphoma. International journal of radiation oncology, biology, physics 103 (4): 851-860,2019.

Men Kuo, Boimel Pamela, Janopaul-Naylor James, Cheng Chingyun, Zhong Haoyu, Huang Mi, Geng Huaizhi, Fan Yong, Plastaras John P, Ben-Josef Edgar, Xiao Ying: A study of positioning orientation effect on segmentation accuracy using convolutional neural networks for rectal cancer. Journal of applied clinical medical physics 20 (1): 110-117,2019.

Men Kuo, Geng Huaizhi, Cheng Chingyun, Zhong Haoyu, Huang Mi, Fan Yong, Plastaras John P, Lin Alexander, Xiao Ying: Technical Note: More accurate and efficient segmentation of organs-at-risk in radiotherapy with convolutional neural networks cascades. Medical physics 46 (1): 286-292,2019.

R. Rengan, R. Mick, D.A. Pryma, L. L. Lin, J. Christodouleas, J.P. Plastaras, C. B. Simone II, A.K. Gupta, T. L. Evans, J. P. Stevenson, C.J. Langer, J. Kucharczuk, J. Friedberg, S. Lam, D. Patsch, S.M. Hahn, A. Maity: A Phase I/II Trial of the HIV Protease Inhibitor Nelfinavir with Concurrent Chemoradiotherapy (CT-RT) for Unresectable Stage IIIA/IIIB Non-Small Cell Lung Cancer (NSCLC): Long Term Clinical Outcomes JAMA Oncology : 2019.

Wo JY, Plastaras JP, Metz JM, Jiang W, Yeap BY, Drapek LC, Baglini C, Ryan DP, Murphy JE, Kwak E, Parikh A, Allen J, Blaszkowsky L, Delaney T, Ben-Josef E, Hong TS: Pencil Beam Scanning Proton Beam Chemoradiotherapy with 5-Fluorouracil and Mitomycin-C for Definitive Treatment of Carcinoma of the Anal Canal: A Multi-institutional Pilot Feasibility Study International Journal of Radiation Oncology, Biology, Physics accepted : 2019.

J Jones, M Alonso-Basanta, A Maity, J Plastaras, S Zhu, W T Arscott: Acute neurologic toxicity of palliative radiotherapy for brain metastases in patients receiving immune checkpoint blockade Neuro-Oncology Practice : 2018.

Men Kuo, Boimel Pamela, Janopaul-Naylor James, Zhong Haoyu, Huang Mi, Geng Huaizhi, Cheng Chingyun, Fan Yong, Plastaras John P, Ben-Josef Edgar, Xiao Ying: Cascaded atrous convolution and spatial pyramid pooling for more accurate tumor target segmentation for rectal cancer radiotherapy. Physics in medicine and biology 63 (18): 185016,2018.

H. Ahmed, A. Pantel, J. Metz, J.P. Plastaras, and M. Farwell: FDG-Avid Focal Liver Reaction from Proton Therapy in a Patient with Primary Esophageal Adenocarcinoma Journal Clinical Nuclear Medicine 43 (5): e139-e141,2018.

Academic Contact Info

Department of Radiation Oncology
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 615-3714
Patient appointments: 800-789-7366 (PENN)

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