Description of Research Expertise:
1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" (ClinicalTrials.gov Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.
2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.
3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.
4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" (ClinicalTrials.gov Identifier: NCT01449864)
K Reiss Binder, O O'Dwyer, M O'Hara, B Bauman, C Schneider, U Teitelbaum, J Plastaras, E Martinez, L Zinck, P Sinclair, T Lawless: Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial Journal of the National Comprehensive Cancer Network : 2018.
K Men, P Boimel, J Janopaul-Naylor, C Y Cheng, H Zhong, M Huang, Y Fan, J Plastaras, E Ben-Josef, Y Xiao: A study of positioning orientation effect on segmentation accuracy using convolutional neural networks for rectal cancer Journal of Applied Clinical Medical Physics : 2018.
J Jones, M Alonso-Basanta, A Maity, J Plastaras, S Zhu, W T Arscott: Acute neurologic toxicity of palliative radiotherapy for brain metastases in patients receiving immune checkpoint blockade Neuro-Oncology Practice : 2018.
Men, Kuo; Boimel, Pamela; Janopaul-Naylor, James; Zhong, Haoyu; Huang, Mi; Geng, Huaizhi; Cheng, Chingyun; Fan, Yong; P. Plastaras, John; Ben-Josef, Edgar; Xiao, Ying: Cascaded atrous convolution and spatial pyramid pooling for more accurate tumor target segmentation for rectal cancer radiotherapy Physics in Medicine and Biology : 2018.
H. Ahmed, A. Pantel, J. Metz, J.P. Plastaras, and M. Farwell: FDG-Avid Focal Liver Reaction from Proton Therapy in a Patient with Primary Esophageal Adenocarcinoma Journal Clinical Nuclear Medicine 43 (5): e139-e141,2018.
Baumann Brian C, Wei Jenny, Plastaras John P, Lukens John N, Damjanov Nevena, Hoteit Maarouf, Hsu Christine, Levine Matthew, Mondschein Jeffrey, Nadolski Gregory, Olthoff Kim, Reiss Kim A, Rosen Mark, Siegelman Evan, Metz James M, Ben-Josef Edgar: Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma: High Rates of Local Control With Low Toxicity. American journal of clinical oncology epub : 2018.
Shabason Jacob E, Chen Jerry, Apisarnthanarax Smith, Damjanov Nevena, Giantonio Bruce, Loaiza-Bonilla Arturo, O'Dwyer Peter J, O'Hara Mark, Reiss Kim A, Teitelbaum Ursina, Wissel Paul, Drebin Jeffrey A, Vollmer Charles, Kochman Michael, Mick Rosemarie, Vergara Norge, Jhala Nirag, Doucette Abigail, Lukens John N, Plastaras John P, Metz James M, Ben-Josef Edgar: A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer. Cancer chemotherapy and pharmacology 81 (3): 609-614,2018.
D Guttmann, N Mitra, J Metz, JP Plastaras, W Feng, S Swisher-McClure: Neoadjuvant chemoradiation is associated with improved overall survival in elderly patients with esophageal cancer Journal of Geriatric Oncology 9 (1): 40-46,2018.
W. Tristram Arscott, Abigail Doucette, Pallavi Kumar, John P. Plastaras, Amit Maity, and Joshua Jones: Tolerability of sequential immune therapy and palliative radiotherapy
to the cervical and thoracic spine
Journal of Radiation Oncology in press : 2018.
Hoppe B S, Hill-Kayser C E, Tseng Y D, Flampouri S, Elmongy H M, Cahlon O, Mendenhall N P, Maity A, McGee L A, Plastaras J P: Consolidative proton therapy after chemotherapy for patients with Hodgkin lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology 28 (9): 2179-2184,2017.