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John P. Plastaras, MD

John P. Plastaras, MD Physician

Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Dr. Plastaras is employed by Penn Medicine.

About Dr. John P. Plastaras

Recognized by Best Doctors in America 2015, 2016

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2008

Clinical Expertise:

  • Anal Cancer
  • Bile Duct Cancer (Cholangiocarcinoma)
  • Blood Cancer
  • Bone Marrow Transplant
  • Cancer Clinical Trials
  • Cancer Pain Management
  • Colon Cancer
  • Cutaneous T-Cell Lymphoma
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Cancer
  • Gastrointestinal Carcinoid Tumor
  • Liver Cancer
  • Lymphoma
  • Multimodal Therapy (MMT)
  • Neuroendocrine Tumors
  • Non-Hodgkin Lymphoma
  • Pancreatic Cancer
  • Proton Therapy
  • Radiation Oncology - Gastroenterology
  • Radiation Treatment
  • Rectal Cancer
  • Small Intestine Cancer
  • Stomach Cancer (Gastric Cancer)
  • Targeted Molecular Therapy

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Vanderbilt University
Residency: Memorial Sloan-Kettering Cancer Center
Residency: Hospital of the University of Pennsylvania


American Board of Radiology, National American Society for Radiation Oncology (ASTRO), National International Lymphoma Radiation Oncology Group (ILROG), International

Hospital Affiliation

Dr. Plastaras is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" ( Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" ( Identifier: NCT01449864)

Selected Publications:

K Reiss Binder, O O'Dwyer, M O'Hara, B Bauman, C Schneider, U Teitelbaum, J Plastaras, E Martinez, L Zinck, P Sinclair, T Lawless: Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial Journal of the National Comprehensive Cancer Network : 2018.

K Men, P Boimel, J Janopaul-Naylor, C Y Cheng, H Zhong, M Huang, Y Fan, J Plastaras, E Ben-Josef, Y Xiao: A study of positioning orientation effect on segmentation accuracy using convolutional neural networks for rectal cancer Journal of Applied Clinical Medical Physics : 2018.

J Jones, M Alonso-Basanta, A Maity, J Plastaras, S Zhu, W T Arscott: Acute neurologic toxicity of palliative radiotherapy for brain metastases in patients receiving immune checkpoint blockade Neuro-Oncology Practice : 2018.

Men, Kuo; Boimel, Pamela; Janopaul-Naylor, James; Zhong, Haoyu; Huang, Mi; Geng, Huaizhi; Cheng, Chingyun; Fan, Yong; P. Plastaras, John; Ben-Josef, Edgar; Xiao, Ying: Cascaded atrous convolution and spatial pyramid pooling for more accurate tumor target segmentation for rectal cancer radiotherapy Physics in Medicine and Biology : 2018.

H. Ahmed, A. Pantel, J. Metz, J.P. Plastaras, and M. Farwell: FDG-Avid Focal Liver Reaction from Proton Therapy in a Patient with Primary Esophageal Adenocarcinoma Journal Clinical Nuclear Medicine 43 (5): e139-e141,2018.

Baumann Brian C, Wei Jenny, Plastaras John P, Lukens John N, Damjanov Nevena, Hoteit Maarouf, Hsu Christine, Levine Matthew, Mondschein Jeffrey, Nadolski Gregory, Olthoff Kim, Reiss Kim A, Rosen Mark, Siegelman Evan, Metz James M, Ben-Josef Edgar: Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma: High Rates of Local Control With Low Toxicity. American journal of clinical oncology epub : 2018.

Shabason Jacob E, Chen Jerry, Apisarnthanarax Smith, Damjanov Nevena, Giantonio Bruce, Loaiza-Bonilla Arturo, O'Dwyer Peter J, O'Hara Mark, Reiss Kim A, Teitelbaum Ursina, Wissel Paul, Drebin Jeffrey A, Vollmer Charles, Kochman Michael, Mick Rosemarie, Vergara Norge, Jhala Nirag, Doucette Abigail, Lukens John N, Plastaras John P, Metz James M, Ben-Josef Edgar: A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer. Cancer chemotherapy and pharmacology 81 (3): 609-614,2018.

D Guttmann, N Mitra, J Metz, JP Plastaras, W Feng, S Swisher-McClure: Neoadjuvant chemoradiation is associated with improved overall survival in elderly patients with esophageal cancer Journal of Geriatric Oncology 9 (1): 40-46,2018.

W. Tristram Arscott, Abigail Doucette, Pallavi Kumar, John P. Plastaras, Amit Maity, and Joshua Jones: Tolerability of sequential immune therapy and palliative radiotherapy to the cervical and thoracic spine Journal of Radiation Oncology in press : 2018.

Hoppe B S, Hill-Kayser C E, Tseng Y D, Flampouri S, Elmongy H M, Cahlon O, Mendenhall N P, Maity A, McGee L A, Plastaras J P: Consolidative proton therapy after chemotherapy for patients with Hodgkin lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology 28 (9): 2179-2184,2017.

Academic Contact Info

Department of Radiation Oncology
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 615-3714
Patient appointments: 800-789-7366 (PENN)

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