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John P. Plastaras, MD

John P. Plastaras, MD Physician

Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Dr. Plastaras is a Penn Medicine employed physician.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

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Clinical Specialties


  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2008

Clinical Expertise:

  • Anal Cancer
  • Bile Duct Cancer
  • Blood Cancer
  • Bone Marrow Transplant
  • Cancer Clinical Trials
  • Cancer Pain Management
  • Colon Cancer
  • Cutaneous T-Cell Lymphoma
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Cancer
  • Gastrointestinal Carcinoid Tumor
  • Liver Cancer
  • Lymphoma
  • Multimodal Therapy (MMT)
  • Neuroendocrine Tumors
  • Non-Hodgkin Lymphoma
  • Pancreatic Cancer
  • Radiation Oncology - Gastroenterology
  • Radiation Treatment
  • Rectal Cancer
  • Small Intestine Cancer
  • Stomach Cancer (Gastric Cancer)
  • Targeted Molecular Therapy

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Vanderbilt University
Residency: Memorial Sloan-Kettering Cancer Center
Residency: Hospital of the University of Pennsylvania


American Association of Cancer Research, National American Board of Radiology, National American College of Radiology, National American Society for Radiation Oncology (ASTRO), National American Society of Clinical Oncology, National Council of Affiliated Regional Radiation Oncology Societies, National International Lymphoma Radiation Oncology Group (ILROG), International Pennsylvania Radiological Society, Local Philadelphia Roentgen Ray Society, Local Radiation Research Society, National Radiologic Society of North America, National

Hospital Affiliation

Dr. Plastaras is a Penn Medicine employed physician.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" ( Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" ( Identifier: NCT01449864)

Selected Publications:

Fernandes Annemarie, Berman Abigail T, Mick Rosemarie, Both Stefan, Lelionis Kristi, Lukens John N, Ben-Josef Edgar, Metz James M, Plastaras John P: A Prospective Study of Proton Beam Reirradiation for Esophageal Cancer. International journal of radiation oncology, biology, physics 95 (1): 483-7,2016.

Datta Jashodeep, McMillan Matthew T, Ruffolo Luis, Lowenfeld Lea, Mamtani Ronac, Plastaras John P, Dempsey Daniel T, Karakousis Giorgos C, Drebin Jeffrey A, Fraker Douglas L, Roses Robert E: Multimodality Therapy Improves Survival in Resected Early Stage Gastric Cancer in the United States. Annals of surgical oncology : 2016.

Zeng C, Plastaras JP, James P, Tochner Z, Hill-Kayser C, Hahn S, and Both S: Proton Pencil Beam Scanning for Mediastinal Lymphoma: Treatment Planning and Robustness Assessment Acta Oncologica In Press : 2016.

Dhakal S, Advani R, Ballas LK, Dabaja BS, Flowers CR, Ha CS, Hoppe BS, Mendenhall NP, Metzger ML, Plastaras JP, Roberts KB, Shapiro R, Smith SM, Terezakis SA, Winkfield KM, Younes A, Constine LS: ACR Appropriateness Criteria® Hodgkin Lymphoma-Favorable Prognosis Stage I and II American Journal of Clinical Oncology : 2016.

Datta Jashodeep, McMillan Matthew T, Ecker Brett L, Karakousis Giorgos C, Mamtani Ronac, Plastaras John P, Giantonio Bruce J, Drebin Jeffrey A, Dempsey Daniel T, Fraker Douglas L, Roses Robert E: Implications of Lymph Node Staging on Selection of Adjuvant Therapy for Gastric Cancer in the United States: A Propensity Score-matched Analysis. Annals of surgery : 2015.

Gandhi SJ, Liang X, Ding X, Zhu TC, Ben-Josef E, Plastaras JP, Metz JM, Both S, Apisarnthanarax S: Clinical decision tool for optimal delivery of liver stereotactic body radiation therapy (SBRT): photons versus protons Practical Radiation Oncology 5 (4): 209-1,2015.

McMillan Matthew T, Ojerholm Eric, Roses Robert E, Plastaras John P, Metz James M, Mamtani Ronac, Karakousis Giorgos C, Fraker Douglas L, Drebin Jeffrey A, Stripp Diana, Ben-Josef Edgar, Datta Jashodeep: Adjuvant Radiation Therapy Treatment Time Impacts Overall Survival in Gastric Cancer. International journal of radiation oncology, biology, physics : 2015.

Datta Jashodeep, McMillan Matthew T, Shang Eric K, Mamtani Ronac, Lewis Russell S, Kelz Rachel R, Teitelbaum Ursina, Plastaras John P, Drebin Jeffrey A, Fraker Douglas L, Karakousis Giorgos C, Roses Robert E: Omission of adjuvant therapy after gastric cancer resection: development of a validated risk model. Journal of the National Comprehensive Cancer Network : JNCCN 13 (5): 531-41,2015.

Fernandes Annemarie T, Apisarnthanarax Smith, Yin Lingshu, Zou Wei, Rosen Mark, Plastaras John P, Ben-Josef Edgar, Metz James M, Teo Boon-Keng: Comparative assessment of liver tumor motion using cine-magnetic resonance imaging versus 4-dimensional computed tomography. International journal of radiation oncology, biology, physics 91 (5): 1034-40,2015.

Ojerholm E, Kirk M, Thompson R, Zhai A, Metz JM, Both S, Ben-Josef E, Plastaras JP: Pencil-beam scanning proton therapy for anal cancer: a dosimetric comparison with intensity-modulated radiotherapy. Acta Oncologica [Epub ahead of print] : 2015.

Academic Contact Info

Department of Radiation Oncology
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 615-3714
Fax: (215) 349-8975
Patient appointments: 800-789-PENN (7366)

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