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John P. Plastaras, MD

John P. Plastaras, MD Physician

Associate Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Dr. Plastaras is employed by Penn Medicine.

About Dr. John P. Plastaras

Recognized by Best Doctors in America 2015, 2016

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2008

Clinical Expertise:

  • Anal Cancer
  • Bile Duct Cancer
  • Blood Cancer
  • Bone Marrow Transplant
  • Cancer Clinical Trials
  • Cancer Pain Management
  • Colon Cancer
  • Cutaneous T-Cell Lymphoma
  • Esophageal Cancer
  • Gallbladder Cancer
  • Gastrointestinal Cancer
  • Gastrointestinal Carcinoid Tumor
  • Liver Cancer
  • Lymphoma
  • Multimodal Therapy (MMT)
  • Neuroendocrine Tumors
  • Non-Hodgkin Lymphoma
  • Pancreatic Cancer
  • Proton Therapy
  • Radiation Oncology - Gastroenterology
  • Radiation Treatment
  • Rectal Cancer
  • Small Intestine Cancer
  • Stomach Cancer (Gastric Cancer)
  • Targeted Molecular Therapy

Description of Clinical Expertise

radiation therapy, lymphoma, gastroinstestinal cancer, proton radiotherapy, total body irradiation

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Vanderbilt University
Residency: Memorial Sloan-Kettering Cancer Center
Residency: Hospital of the University of Pennsylvania


American Board of Radiology, National American Society for Radiation Oncology (ASTRO), National American Society of Clinical Oncology, National International Lymphoma Radiation Oncology Group (ILROG), International

Hospital Affiliation

Dr. Plastaras is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

1. Reirradiation with Proton Therapy: He is the Principal Investigator for the ongoing multicenter clinical study "Proton Radiotherapy for Recurrent Tumors" ( Identifier: NCT01126476). He is interested in factors that increase the risk of toxicity from reirradiation as well as factors that predict for radioresistance in these recurrent tumors.

2. Decreasing Toxicity of Lymphoma Radiotherapy: Interests include developing proton radiotherapy techniques for patients with lymphoma, developing models for predicting radiation-related toxicity, and using highly conformal techniques.

3. Using Moleclar Imaging to Estimate Radiation Dose during Radioimmunotherapy.

4. Proton therapy for gastrointestinal (GI) malignancies: He is the Principal Investigator for the clinical study "Proton therapy for upper GI cancers" ( Identifier: NCT01449864)

Selected Publications:

H. Ahmed, A. Pantel, J. Metz, J. Plastaras, and M. Farwell: FDG-Avid Focal Liver Reaction from Proton Therapy in a Patient with Primary Esophageal Adenocarcinoma Journal Clinical Nuclear Medicine : 2018.

D Guttmann, N Mitra, J Metz, J Plastaras, W Feng, S Swisher-McClure: Neoadjuvant chemoradiation is associated with improved overall survival in elderly patients with esophageal cancer Journal of Geriatric Oncology : 2017.

D Guttmann, M Frick, R Carmona, C Deville Jr., W Levin, A Berman, C Chinniah, S Hahn, J Plastaras, C Simone II: A prospective study of proton reirradiation for recurrent and secondary soft tissue sarcoma Radiotherapy and Oncology (The Green Journal) : 2017.

Y Tseng, D Cutter, J Plastaras, R Parikh, O Cahlon, M Chuong, K Dedeckova, M Kahn, S Lin, L McGee, E Shen, S Terezakis, S Badiyan, Y Kirova, R Hoppe, N Mendenhall, M Pankuch, S Flampouri, U Ricardi, B Hoppe: Evidence-Based Review on the Utilization of Proton Therapy in Lymphoma from the Particle Therapy Cooperative Group Lymphoma Subcommittee International Journal of Radiation Oncology, Biology, Physics : 2017.

S. Dhakal, R. Advani, L. Ballas, B. Dabaja, C. Flowers, C. Ha, b. Hoppe, N. Mendenhall, M. Metzger, J. Plastaras, K. Roberts, R. Shapiro, S. Smith, S. Terezakis, K. Winkfield, A. Younes and L. Constine.: ACR Appropriateness Criteria® Hodgkin Lymphoma-Favorable Prognosis Stage I and II American Journal of Clinical Oncology 39 (6): 535,2016.

K Winkfield, R Advani, L Ballas, B Dabaja, S Dhakal, C Flowers, C Soo Ha, B Hoppe, D Mansur, N Mendenhall, M Metzger, J Plastaras, K Roberts, R Shapiro, S Smith, S Terezakis, A Younes, L Constine: ACR Appropriateness Criteria® Recurrent Hodgkin Lymphoma The Oncology Journal : 2016.

Fernandes Annemarie, Berman Abigail T, Mick Rosemarie, Both Stefan, Lelionis Kristi, Lukens John N, Ben-Josef Edgar, Metz James M, Plastaras John P: A Prospective Study of Proton Beam Reirradiation for Esophageal Cancer. International journal of radiation oncology, biology, physics 95 (1): 483-7,2016.

Datta Jashodeep, McMillan Matthew T, Ruffolo Luis, Lowenfeld Lea, Mamtani Ronac, Plastaras John P, Dempsey Daniel T, Karakousis Giorgos C, Drebin Jeffrey A, Fraker Douglas L, Roses Robert E: Multimodality Therapy Improves Survival in Resected Early Stage Gastric Cancer in the United States. Annals of surgical oncology : 2016.

Zeng C, Plastaras JP, James P, Tochner Z, Hill-Kayser C, Hahn S, and Both S: Proton Pencil Beam Scanning for Mediastinal Lymphoma: Treatment Planning and Robustness Assessment Acta Oncologica In Press : 2016.

Dhakal S, Advani R, Ballas LK, Dabaja BS, Flowers CR, Ha CS, Hoppe BS, Mendenhall NP, Metzger ML, Plastaras JP, Roberts KB, Shapiro R, Smith SM, Terezakis SA, Winkfield KM, Younes A, Constine LS: ACR Appropriateness Criteria® Hodgkin Lymphoma-Favorable Prognosis Stage I and II American Journal of Clinical Oncology : 2016.

Academic Contact Info

Department of Radiation Oncology
Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 615-3714
Patient appointments: 800-789-7366 (PENN)

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