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John Nicholas Lukens, MD

John Nicholas Lukens, MD Physician

Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Dr. Lukens is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2014

Clinical Expertise:

  • Brachytherapy
  • Melanoma
  • Proton Therapy
  • Skin Cancer

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Mount Sinai Medical Center


American Brachytherapy Society, National American College of Radiology, National American Society for Radiation Oncology (ASTRO), National American Society of Clinical Oncology, National National Comprehensive Cancer Network (NCCN), National

Hospital Affiliation

Dr. Lukens is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My research focuses on the multidisciplinary management of head and neck cancers, in particular novel strategies to understand and mitigate the toxicities associated with head and neck radiotherapy. Additionally, I am interested in identifying subsets of patients with HPV+ cancer who may benefit from treatment de-intensification, and conversely, those with high-risk disease who may benefit from novel targeted therapy and/or immunotherapy.

Selected Publications:

LaRiviere MJ, Avery RA, Dolan JG, Adamson PC, Zarnow DM, Xie Y, Avery SM, Kurtz GA, Hill-Kayser CE, Lustig RA, Lukens JN: Emergent radiation for leukemic optic nerve infiltration in a child receiving intrathecal methotrexate Pract Radiat Oncol : 2019.

Rwigema JM, Langendijk JA, Paul van der Laan H, Lukens JN, Swisher-McClure SD, Lin A: A Model-Based Approach to Predict Short-Term Toxicity Benefits With Proton Therapy for Oropharyngeal Cancer Int J Radiat Oncol Biol Phys : 2019.

Jahan Mohiuddin, MD; Rabie M. Shanti, DMD, MD; Faizan Alawi, DDS; Brian M. Chang, DDS; Neil Taunk, MD; John N. Lukens, MD: HDR Brachytherapy for Primary Treatment of Recurrent Oral Proliferative Verrucous Leukoplakia (PVL) of the Hard Palate: A Case Report ABS Meeting : 2019.

Grewal, A. et al.: Pharyngeal Sparing Radiation for Head and Neck Carcinoma of Unknown Primary following TORS assisted work-up The Laryngoscope : 2019.

J. Nicholas Lukens, Sergei Pustylnikov, Kathy Montone, Mike Feldman, Alexander Lin, Sam Swisher-McClure, Gregory Weinstein, Andrea Facciabene: Tumor Infiltrating Lymphocytes in “Occult Primary” HPV+ Oropharyngeal Squamous Cell Carcinoma (OPSCC): Comparison of the Primary Tumor and Regional Lymph Node Metastases ASTRO 2019 Annual Meeting : 2019.

Li T, Scheuermann R, Lin A, Teo BK, Zou W, Swisher-McClure S, Alonso-Basanta, M, Lukens JN, Fotouhi Ghiam A, Kennedy C, Kim MM, Mihailidis D, Metz JM, Dong L: Impact of Multi-leaf Collimator Parameters on Head and Neck Plan Quality and Delivery: A Comparison between Halcyon™ and Truebeam® Treatment Delivery Systems Cureus 10 (11): e3648,2018.

Caitlin Schonewolf, Hann-Hsiang Chao, David Guttmann, Samuel Swisher-McClure, Alireza Fotouhi Ghiam, Alexander Lin, John Lukens: Lymphovascular Invasion, and Number of Neck Levels Involved Predict Distant Failure in p16+ Oropharyngeal Squamous Cell Carcinoma (OPSCC) Following Transoral Robotic Surgery (TORS) ASTRO Annual Meeting 2018 : 2018.

Amit Maity, Rosemarie Mick, Alexander Huang, Sangeet George, Michael Farwell, John Lukens, Abigail Berman, Tara Mitchell, Joshua Bauml, Lynn Schuchter, Mark O'Hara, Lilie Lin, Angela DeMichele, John Christodouleas, Naomi Haas, Dana Patsch, Stephen Hahn, Andy Minn, E Wherry, Robert Vonderheide: A Phase I Trial Of Pembrolizumab With Hypofractionated Radiotherapy (HFRT) In Patients With Metastatic Cancers ASTRO Annual Meeting 2018 : 2018.

Amit Maity, Rosemarie Mick, Alexander Huang, Sangeet George, Michael Farwell, John Lukens, Abigail Berman, Tara Mitchell, Joshua Bauml, Lynn Schuchter, Mark O'Hara, Lilie Lin, Angela Demichele, John Christodouleas, Naomi B Haas, Dana Patsch, Stephen Hahn, Andy Minn, E. Wherry, and Robert Vonderheide: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. British Journal of Cancer 119 (10): 1200-1207,2018.

Michael LaRiviere, Shannon O'Reilly, Alireza Fotouhi Ghiam, Samuel Swisher-McClure, Alexander Lin, Boon-Keng Kevin Teo, John Lukens: Clinically Significant Organ-at-risk Dose Reductions Are Achieved with IMRT Plan Optimization to Clinical Target Volume (CTV) with Setup Uncertainty Analysis ASTRO Annual Meeting 2018 102 (3): e529,2018.

Academic Contact Info

Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: (215) 662-6567
Patient appointments: 800-789-7366 (PENN)