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John N. Lukens, MD

John N. Lukens, MD Physician

Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania

Languages spoken:

  • French

Dr. Lukens is a Penn Medicine employed physician.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Radiation Oncology

Programs & Centers:

Board Certification:

  • Radiation Oncology, 2014

Clinical Expertise:

  • Cancer Clinical Trials
  • Esophageal Cancer
  • Eyelid Tumors
  • Gastrointestinal Cancer
  • Head and Neck Tumor
  • Mouth Cancer (Oral Cancer)
  • Orbital Tumors
  • Pancreatic Cancer
  • Prostate Cancer
  • Radiation Oncology - Gastroenterology
  • Radiation Oncology - Head/Neck
  • Rectal Cancer
  • Sinus Cancer
  • Skin Cancer
  • Submandibular Tumor
  • Throat Cancer

Description of Clinical Expertise

My clinical expertise is in the treatment of head and neck cancers and gastrointestinal cancers. Additionally, I have specialized training in brachytherapy, which consists of placing radioactive sources within, or directly adjacent to a tumor, as a means of delivering highly targeted radiation. I have experience in head and neck, prostate, and gastrointestinal brachytherapy, as well as intra-operative radiotherapy. I have a particular clinical interest in the re-treatment of patients who have undergone a prior course of radiation, through the integration of highly targeted techniques such as proton therapy and brachytherapy. I believe strongly in the importance of an interdisciplinary approach, and work closely with my surgical and medical oncology colleagues to optimize patient outcomes.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Mount Sinai Medical Center


American Brachytherapy Society , National American College of Radiology, National American Society for Radiation Oncology (ASTRO), National American Society of Clinical Oncology, National

Hospital Affiliation

Dr. Lukens is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My research focuses on the multidisciplinary management of head and neck cancers, in particular novel strategies to understand and mitigate the toxicities associated with head and neck radiotherapy. Additionally, I am interested in identifying subsets of patients with HPV+ cancer who may benefit from treatment de-intensification, and conversely, those with high-risk disease who may benefit from novel targeted therapy and/or immunotherapy.

Selected Publications:

Hatten KM, O'Malley BW Jr, Bur AM, Patel MR, Rassekh CH, Newman JG, Cannady SB, Chalian AA, Hodnett BL, Lin A, Lukens JN, Cohen RB, Bauml JM, Montone KT, Livolsi VA, Weinstein GS: Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries. JAMA Otolaryngol Head Neck Surg 143 (3): 267-273,2017.

Gamez M, Agarwal M, Hu KS, Lukens JN, Harrison LB: Hypofractionated palliative radiotherapy with concurrent radiosensitizing chemotherapy for advanced head and neck cancer using the QUAD-SHOT regimen Anticancer research : 2017.

Daniel M. Trifiletti, Andrew Smith, Nandita Mitra, Surbhi Grover, John N. Lukens, Roger B. Cohen, Paul Read, William M. Mendenhall, Alexander Lin, Samuel Swisher-McClure: Beyond Positive Margins and Extracapsular Extension: Evaluating the Utilization and Clinical Impact of Postoperative Chemoradiotherapy in Resected Locally Advanced Head and Neck Cancer Journal of Clinical Oncology : 2017.

Eric Ojerholm, J. Nicholas Lukens, Peter H. Ahn, Geoffrey Geiger, Samuel Swisher-McClure, Jason Newman, Ara Chalian, Gregory Weinstein, Bert W. O'Malley Jr., Roger Cohen, Alexander Lin: Benefits of omitting primary site radiotherapy after TORS: only time will tell Practical Radiation Oncology : 2016.

Sharma S, Bekelman J, Lin A, Lukens JN, Roman BR, Mitra N, Swisher-McClure S: Clinical impact of prolonged diagnosis to treatment interval (DTI) among patients with oropharyngeal squamous cell carcinoma Oral Oncology 56 : 17-24,2016.

Annemarie Fernandes, MD Abigail T. Berman, MD Rosemarie Mick, MS Stefan Both, PhD Kristi Lelionis, MS John N. Lukens, MD Edgar Ben-Josef, MD James M. Metz, MD John P. Plastaras, MD, PhD: A Prospective Study of Proton Beam Reirradiation for Esophageal Cancer International Journal of Radiation Oncology, Biology, Physics : 2016.

Sarah A. Milgrom, Shekeab Jauhari, John P. Plastaras, Yago Nieto, Grace L. Smith, Chelsea C. Pinnix, Bouthaina S. Dabaja, Pamela K. Allen, J. Nicholas Lukens, Amit Maity, Yasuhiro Oki, Michelle A. Fanale, and Sunita D. Nasta: A Multi-Institutional Analysis of Peri-Transplant Radiation Therapy in Patients with Relapsed/Refractory Hodgkin Lymphoma Undergoing Autologous Stem Cell Transplantation Cancer : 2016.

Surbhi Grover, Nandita Mitra, Fei Wan, John N. Lukens, Sonam Sharma, Jessica Bauman, Farzad Masroor, Roger B. Cohen, Arati Desai, Kenneth Algazy, Michelle Alonso-Basanta, Peter Ahn, Boon-Keng Kevin Teo, Ara A. Chalian, Gregory S. Weinstein, Bert W. O’Malley, Jr, Alexander Lin: A Single-institution Comparison of Cetuximab, Carboplatin, and Paclitaxel Induction Chemotherapy Followed by Chemoradiation (CRT) Versus CRT for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (LA-SCCHN) American Journal of Clinical Oncology : 2016.

David J. Thomson, Boon-Keng Kevin Teo, Ashley Ong, Khong Wei Ang, Maura Kirk, Peter H. Ahn, John N. Lukens, Samuel Swisher-McClure, Tom Liptrot, Timothy D. Solberg, Nick J. Slevin, Alexander Lin, MD: The Impact of Anatomic Change on Pencil Beam Scanning in the Treatment of Oropharynx Cancer International Journal of Particle Therapy 2 (2): 393-403,2015.

Surbhi Grover, Samuel Swisher-McClure, Nandita Mitra, Jiaqi Li, Roger B Cohen, Peter H Ahn, John N Lukens, Ara A Chalian, Gregory S Weinstein, Bert W O'Malley, Jr, Alexander Lin: Total Laryngectomy Versus Larynx Preservation for T4a Larynx Cancer: Patterns of Care and Survival Outcomes International Journal of Radiation Oncology, Biology, Physics 92 (3): 594-601,2015.

Academic Contact Info

Perelman Center for Advanced Medicine
3400 Civic Center Blvd.

Philadelphia, PA 19104
Phone: 215-662-6567
Patient appointments: 800-789-7366 (PENN)