Description of Research Expertise:
My research focuses on the multidisciplinary management of head and neck cancers, in particular novel strategies to understand and mitigate the toxicities associated with head and neck radiotherapy. Additionally, I am interested in identifying subsets of patients with HPV+ cancer who may benefit from treatment de-intensification, and conversely, those with high-risk disease who may benefit from novel targeted therapy and/or immunotherapy.
Selected Publications:
LaRiviere MJ, Avery RA, Dolan JG, Adamson PC, Zarnow DM, Xie Y, Avery SM, Kurtz GA, Hill-Kayser CE, Lustig RA, Lukens JN: Emergent radiation for leukemic optic nerve infiltration in a child receiving intrathecal methotrexate Pract Radiat Oncol : 2019.
Rwigema JM, Langendijk JA, Paul van der Laan H, Lukens JN, Swisher-McClure SD, Lin A: A Model-Based Approach to Predict Short-Term Toxicity Benefits With Proton
Therapy for Oropharyngeal Cancer Int J Radiat Oncol Biol Phys : 2019.
Jahan Mohiuddin, MD; Rabie M. Shanti, DMD, MD; Faizan Alawi, DDS; Brian M. Chang, DDS; Neil Taunk, MD; John N. Lukens, MD: HDR Brachytherapy for Primary Treatment of Recurrent Oral Proliferative Verrucous Leukoplakia (PVL) of the Hard Palate: A Case Report ABS Meeting : 2019.
J. Nicholas Lukens, Sergei Pustylnikov, Kathy Montone, Mike Feldman, Alexander Lin, Sam Swisher-McClure, Gregory Weinstein, Andrea Facciabene: Tumor Infiltrating Lymphocytes in “Occult Primary” HPV+ Oropharyngeal Squamous Cell Carcinoma (OPSCC): Comparison of the Primary Tumor and Regional Lymph Node Metastases ASTRO 2019 Annual Meeting : 2019.
Li T, Scheuermann R, Lin A, Teo BK, Zou W, Swisher-McClure S, Alonso-Basanta, M, Lukens JN, Fotouhi Ghiam A, Kennedy C, Kim MM, Mihailidis D, Metz JM, Dong L: Impact of Multi-leaf Collimator Parameters on Head and Neck Plan Quality and
Delivery: A Comparison between Halcyon™ and Truebeam® Treatment Delivery Systems Cureus 10 (11): e3648,2018.
Caitlin Schonewolf, Hann-Hsiang Chao, David Guttmann, Samuel Swisher-McClure, Alireza Fotouhi Ghiam, Alexander Lin, John Lukens: Lymphovascular Invasion, and Number of Neck Levels Involved Predict Distant Failure in p16+ Oropharyngeal Squamous Cell Carcinoma (OPSCC) Following Transoral Robotic Surgery (TORS) ASTRO Annual Meeting 2018 : 2018.
Amit Maity, Rosemarie Mick, Alexander Huang, Sangeet George, Michael Farwell, John Lukens, Abigail Berman, Tara Mitchell, Joshua Bauml, Lynn Schuchter, Mark O'Hara, Lilie Lin, Angela DeMichele, John Christodouleas, Naomi Haas, Dana Patsch, Stephen Hahn, Andy Minn, E Wherry, Robert Vonderheide: A Phase I Trial Of Pembrolizumab With Hypofractionated Radiotherapy (HFRT) In Patients With Metastatic Cancers ASTRO Annual Meeting 2018 : 2018.
Amit Maity, Rosemarie Mick, Alexander Huang, Sangeet George, Michael Farwell, John Lukens, Abigail Berman, Tara Mitchell, Joshua Bauml, Lynn Schuchter, Mark O'Hara, Lilie Lin, Angela Demichele, John Christodouleas, Naomi B Haas, Dana Patsch, Stephen Hahn, Andy Minn, E. Wherry, and Robert Vonderheide: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours. British Journal of Cancer 119 (10): 1200-1207,2018.
Michael LaRiviere, Shannon O'Reilly, Alireza Fotouhi Ghiam, Samuel Swisher-McClure, Alexander Lin, Boon-Keng Kevin Teo, John Lukens: Clinically Significant Organ-at-risk Dose Reductions Are Achieved with IMRT Plan Optimization to Clinical Target Volume (CTV) with Setup Uncertainty Analysis ASTRO Annual Meeting 2018 102 (3): e529,2018.
Venigalla S, Plastaras J, Ben-Josef E, Wojcieszynski A, Chowdhry A, Metz J, Lukens JN, Mahmoud N, Shabason J, Reiss K: Comparative Effectiveness of Neoadjuvant Chemoradiation versus Upfront Surgery in the Management of Recto-Sigmoid Junction Cancer Clinical colorectal cancer 17 (3): e557-e568,2018.