Description of Research Expertise

My research focuses on the multidisciplinary management of head and neck cancers, in particular novel strategies to understand and mitigate the toxicities associated with head and neck radiotherapy. Additionally, I am interested in identifying subsets of patients with HPV+ cancer who may benefit from treatment de-intensification, and conversely, those with high-risk disease who may benefit from novel targeted therapy and/or immunotherapy.

Selected Publications

Wright CM, Lee DY, Shimunov D, Carmona R, Barsky AR, Sun L, Cohen RB, Bauml JM, Brody RM, Basu D, Rassekh CH, Chalian AA, Newman JG, Rajasekaran K, Weinstein GS, Lukens JN, Lin A, Swisher-McClure S: Definitive tumor directed therapy confers a survival advantage for metachronous oligometastatic HPV-associated oropharyngeal cancer following trans-oral robotic surgery Oral Oncol 121 : 105509,2021.

Wright C, Baron J, Lee DY, Kim M, Teo K, Lukens JN, Lin A: Dosimetric Results for Adjuvant Proton Radiation Therapy of HPV-Associated Oropharynx Cancer International Journal of Particle Therapy : 2021.

Arscott WT, Nead KT, Bear A, Venigalla S, Shabason J, Lukens JN, Plastaras JP, Wojcieszynski A, Metz J, O'Hara M, Reiss KA, Teitelbaum U, Loaiza-Bonilla A, Drebin J, Lee MK 4th, Shroff SG, Ben-Josef E.: Concurrent Nab-paclitaxel and Radiotherapy: Novel Radiosensitization for Borderline Resectable or Unresectable Pancreatic Cancer Am J Clin Oncol 44 : 469-474,2021.

Straker RJ 3rd, Song Y, Sun J, Shannon AB, Cohen LS, Muradova E, Daou H, Krause K, Li S, Frederick DT, Rhodin KE, Brizel DM, Boland GM, Beasley GM, Wuthrick EJ, Sondak VK, Zager JS, Lin A, Lukens JN*, Karakousis GC*., (*Contributed equally): Adjuvant radiation therapy for clinical stage III melanoma in the modern therapeutic era Ann Surg Oncol 28 (7): 3512-3521,2021.

Kassaee A, Cheng C, Yin L, Zou W, Li T, Lin A, Swisher-McClure S, Lukens JN, Lustig RA, O'Reilly S, Dong L, Ms RH, Teo BK.: Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units Int J Part Ther 8 : 62-72,2021.

Carey RM, Brody RM, Shimunov D, Shinn JR, Mady LJ, Rajasekaran K, Cannady SB, Lin A, Lukens JN, Bauml JM, Cohen RB, Basu D, O'Malley BW Jr, Weinstein GS, Newman JG.: Locoregional Recurrence in p16-Positive Oropharyngeal Squamous Cell Carcinoma After TORS Laryngoscope : 2021.

Mohiuddin JJ, Shanti RM, Alawi F, Chang BM, Marcel J, Taunk NK, Lukens JN.: High-Dose-Rate Brachytherapy for Primary Treatment of Refractory Proliferative Verrucous Leukoplakia of the Hard Palate Cureus 13 : e15696,2021.

Carey RM, Shimunov D, Weinstein GS, Cannady SB, Lukens JN, Lin A, Swisher-McClure S, Bauml JM, Aggarwal C, Cohen RB, Newman JG, Chalian AA, Rassekh CH, Basu D, O'Malley BW Jr, Rajasekaran K, Brody RM: Increased Rate of Recurrence and High Rate of Salvage in Patients with HPV-associated Oropharyngeal Squamous Cell Carcinoma with Adverse Features Treated with Primary Surgery without Recommended Adjuvant Therapy Head and Neck 42 (4): 1128-1141,2021.

Mohiuddin JJ, Chu B, Facciabene A, Poirier K, Wang X, Doucette A, Zheng C, Xu W, Anstadt EJ, Amaravadi RK, Karakousis GC, Mitchell TC, Huang AC, Shabason JE, Lin A, Swisher-McClure S, Maity A, Schuchter LM, Lukens JN: Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy J Natl Cancer Inst 113 (2): 162-170,2021.

Butala AA, Jain V, Reddy VK, Sebro RA, Song Y, Karakousis G, Mitchell TC, Lukens JN, Shabason JE: Impact of Tumor-Infiltrating Lymphocytes on Overall Survival in Merkel Cell Carcinoma Oncologist 1 (26): 63-69,2021.

Academic Contact Information

Perelman Center for Advanced Medicine
3400 Civic Center Blvd.
2-West
Philadelphia, PA 19104
Phone: 215-662-6567
Patient appointments: 800-789-7366