Description of Research Expertise:
My research focuses on the multidisciplinary management of head and neck cancers, in particular novel strategies to understand and mitigate the toxicities associated with head and neck radiotherapy. Additionally, I am interested in identifying subsets of patients with HPV+ cancer who may benefit from treatment de-intensification, and conversely, those with high-risk disease who may benefit from novel targeted therapy and/or immunotherapy.
Routman DM, Funk RK, Tangsriwong K, Lin A, Keeney MG, García JJ, Zarka MA, Lewis JT, Stoddard DG, Moore EJ, Day CN, Zhai Q, Price KA, Lukens JN, Swisher-McClure S, Weinstein GS, O'Malley BW Jr, Foote RL: Relapse Rates With Surgery Alone in Human Papillomavirus-Related Intermediate- and High-Risk Group Oropharynx Squamous Cell Cancer: A Multi-Institutional Review Int J Radiat Oncol Biol Phys : 2017.
Hatten KM, O'Malley BW Jr, Bur AM, Patel MR, Rassekh CH, Newman JG, Cannady SB, Chalian AA, Hodnett BL, Lin A, Lukens JN, Cohen RB, Bauml JM, Montone KT, Livolsi VA: Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries. JAMA Otolaryngol Head Neck Surg 143 (3): 267-273,2017.
Gamez M, Agarwal M, Hu KS, Lukens JN: Hypofractionated palliative radiotherapy with concurrent radiosensitizing chemotherapy for advanced head and neck cancer using the QUAD-SHOT regimen Anticancer research : 2017.
Rwigema, Jean-Claude, Swisher-McClure, Samuel, Laan, HP van der, Lukens, John, Lin, Alexander, Langendijk: Proton therapy improves toxicity for oropharyngeal cancer: an outcomes and predictive model-based approach ASTRO 2017 : 2017.
Orly M Coblens, Joshua Earl, Garth D. Ehrlich, Noam A Cohen, John N Lukens: Microbiomes and Mucositis During Head & Neck Radiotherapy The American Academy of Otolaryngology–Head and Neck Surgery Annual Meeting 2017 : 2017.
Mohammad Mousavian, Yasmin Mattar, Jakub Svoboda, Lauren Strelec, Peter Gabriel, John Lukens: Characterization of Toxicities Associated with Radiotherapy for Head and Neck Lymphomas ASTRO 2017 Annual Meeting : 2017.
Jared Gershowitz, Abigail Doucette, John N Lukens, Samuel Swisher-McClure, Geoffrey Geiger: Pathologic Risk Factors Associated with Contralateral Neck Disease in Patients with Tonsil Cancer: Implications on Patient Selection for Unilateral Neck Radiotherapy ASTRO 2017 : 2017.
Brian C. Baumann, Jenny Wei, John P. Plastaras, John N. Lukens, Nevena Damjanov, Maarouf Hoteit, Christine Hsu, Matthew Levine, Jeffrey Mondschein, Gregory Nadolski, Kim Olthoff, Kim Reiss Binder, Mark Rosen, Evan Siegelman, James M. Metz: Stereotactic Body Radiation Therapy (SBRT) for Hepatocellular Carcinoma: High Rates of Local Control with Low Toxicity American Journal of Clinical Oncology : 2017.
Apinorasethkul O, Kirk M, Teo K, Swisher-McClure S, Lukens JN: Pencil beam scanning proton therapy vs rotational arc radiation therapy: A treatment planning comparison for postoperative oropharyngeal cancer Med Dosim 42 (1): 7-11,2017.
Daniel M. Trifiletti, Andrew Smith, Nandita Mitra, Surbhi Grover, John N. Lukens, Roger B. Cohen, Paul Read, William M. Mendenhall, Alexander Lin: Beyond Positive Margins and Extracapsular Extension: Evaluating the Utilization and Clinical Impact of Postoperative Chemoradiotherapy in Resected Locally Advanced Head and Neck Cancer Journal of Clinical Oncology : 2017.