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John A. Detre, MD

John A. Detre, MD Physician

Director, Center for Functional Imaging Professor of Radiology Professor of Neurology

Dr. Detre is employed by Penn Medicine.

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Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1994

Clinical Expertise:

  • Abnormal Reflexes
  • Alzheimer's Disease
  • Arm Weakness
  • Arteriovenous Malformations (AVM)
  • Ataxia
  • Bell's Palsy
  • Benign Paroxysmal Positional Vertigo
  • Carotid Stenosis
  • Cerebellar Ataxia
  • Cerebellar Disease
  • Cerebral Aneurysm
  • Cerebrovascular Accident
  • Cervical Dystonia
  • Charcot Marie Tooth Disease (CMT)
  • CNS Vasculitis
  • Cognitive Impairment
  • Concussion
  • Cranial Nerve Injuries
  • Encephalopathies
  • Epilepsy
  • Facial Droop
  • Facial Nerve Pain (Neuralgia)
  • Facial Pain
  • Guillain-BarrĂ© Syndrome (GBS)
  • Headache
  • Leg Weakness
  • Lip Droop
  • Lobar Atrophy of Brain
  • Medication Overuse Headache
  • Memory Disorders
  • Movement Disorders
  • Multiple Sclerosis (MS)
  • Muscle Weakness
  • Myasthenia Gravis (MG)
  • Myelitis
  • Nerve Root Pain
  • Nervous System Disorders
  • Neuromuscular Disorders
  • Neuropathy
  • Nonruptured Cerebral Aneurysm
  • Orthostatic Hypotension
  • Paraplegia
  • Paresthesia
  • Parkinson's Disease
  • Peripheral Nerve Disorders
  • Peripheral Neuropathy
  • Periventricular Leukomalacia
  • Positional Vertigo
  • Primary Cerebellar Degeneration
  • Primary Progressive Aphasia
  • Pseudotumor Cerebri
  • Quadriplegia
  • Radiculopathy
  • Sensory Impairment
  • Spinocerebellar Ataxia
  • Spinocerebellar Degeneration
  • Spinocerebellar Diseases
  • Stroke
  • Subarachnoid Hemorrhage
  • Syncope
  • Tetraplegia
  • Tinnitus
  • Torticollis
  • Transient Ischemic Attack
  • Traumatic Brain Injury (TBI)
  • Tremor
  • Trigeminal Nerve Disorders
  • Trigeminal Neuralgia (Tic Douloureux)
  • Unsteady Gait
  • Vertigo
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Yale University
Residency: University Health Center of Pittsburgh
Residency: Hospital of the University of Pennsylvania


American Academy of Neurology, National American Association for the Advancement of Science (AAAS), National Center for Cognitive Neuroscience (Univ. of Penna.), Local David Mahoney Institute of Neurological Sciences (Univ. of Penna.), Local International Society of Magnetic Resonance in Medicine, International National Headache Foundation, National Philadelphia Neurological Society, Local Society for Neuroscience, National Stroke Council, American Heart Association, National

Hospital Affiliation

Dr. Detre is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

magnetic resonance, brain mapping, cerebral blood flow, brain injury

Physiology and pathophysiology of functional activation. Clinical and translational neuroimaging. Imaging in stroke. Imaging in epilepsy. Imaging of recovery of function. Imaging in sleep research.

Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.

Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, and strokes. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods. There is a large component of data analysis and processing using statistical parametric mapping and other computational methods. In addition, the physiological basis and pathophysiological influences on functional activation are studied using a rat model. The research is carried out in collaboration with investigators from Radiology Research, the Cerebrovascular Research Center, Cognitive Neurology, and the Epilepsy Center.

Selected Publications:

Alsop, D. C., Detre, J. A., Golay, X., Gunther, M., Hendrikse, J., Hernandez-Garcia, L., Lu, H., Macintosh, B. J., Parkes, L. M., Smits, M., van Osch, M. J., Wang, D. J., Wong, E. C., Zaharchuk, G.: Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia Magn Reson Med : 2014.

Wang, Z., Li, Y., Childress, A. R., Detre, J. A.: Brain entropy mapping using fMRI PLoS ONE 9 (3): e89948,2014.

Satterthwaite, T. D., Shinohara, R. T., Wolf, D. H., Hopson, R. D., Elliott, M. A., Vandekar, S. N., Ruparel, K., Calkins, M. E., Roalf, D. R., Gennatas, E. D., Jackson, C., Erus, G., Prabhakaran, K., Davatzikos, C., Detre, J. A., Hakonarson, H., Gur, R. C., Gur, R. E.: Impact of puberty on the evolution of cerebral perfusion during adolescence Proc Natl Acad Sci U S A 111 (23): 8643-8,2014.

Kandel, B.M., Wang, D. J.J., Detre, J.A., Gee, J.C., Avants, B.B.: Decomposing cerebral blood flow MRI into functional and structural components: A non-local approach based on prediction Neuroimage in press : 2014.

Favilla, C. G., Mesquita, R. C., Mullen, M., Durduran, T., Lu, X., Kim, M. N., Minkoff, D. L., Kasner, S. E., Greenberg, J. H., Yodh, A. G., Detre, J. A.: Optical Bedside Monitoring of Cerebral Blood Flow in Acute Ischemic Stroke Patients During Head-of-Bed Manipulation Stroke : 2014.

Franklin, T. R., Wang, Z., Shin, J., Jagannathan, K., Suh, J. J., Detre, J. A., O'Brien, C. P., Childress, A. R.: A VBM study demonstrating ''apparent'' effects of a single dose of medication on T1-weighted MRIs Brain structure & function 218 (1): 97-104,2013.

Weber, M. J., Detre, J. A., Thompson-Schill, S. L., Avants, B. B.: Reproducibility of functional network metrics and network structure: A comparison of task-related BOLD, resting ASL with BOLD contrast, and resting cerebral blood flow Cogn Affect Behav Neurosci : 2013.

Wang, A., Das, S.R., Xie, S.X., Arnold, S.E., Detre, J.A., Wolk, D.A.: Arterial spin labeled MRI in prodromal Alzheimer''s disease: A multi-site study NeuroImage: Clinical 2 : 630-36,2013.

Mesquita, R. C., Schenkel, S. S., Minkoff, D. L., Lu, X., Favilla, C. G., Vora, P. M., Busch, D. R., Chandra, M., Greenberg, J. H., Detre, J. A., Yodh, A. G.: Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions Biomed Opt Express 4 (7): 978-94,2013.

Mesquita, R. C., Faseyitan, O. K., Turkeltaub, P. E., Buckley, E. M., Thomas, A., Kim, M. N., Durduran, T., Greenberg, J. H., Detre, J. A., Yodh, A. G., Hamilton, R. H.: Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex J Biomed Opt 18 (6): 067006,2013.

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Academic Contact Info

3 W Gates Building
3400 Spruce Street
Office: 517 Goddard Labs

Philadelphia, PA 19104
Phone: (215) 349-8465
Patient appointments: 800-789-7366 (PENN)

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