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John S. J. Brooks, MD, FRCPath

John S. J. Brooks, MD, FRCPath Physician

Chair, Pathology, Pennsylvania Hospital Director for Pathology and Laboratory Medicine at Pennsylvania Hospital Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

Dr. Brooks is employed by Penn Medicine.

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About Dr. John S. Brooks

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Best Doctors in America 2011, 2012, 2015 - 2018

Recognized annually in Philadelphia magazine's Top Docs issues from 2007 to 2018

My clinical expertise is in Diagnosis of Sarcoma and Soft Tissue Tumors; Diagnosis of Rare Cancers; Pathology Tissue (Biopsy) Diagnosis of many cancer types.

Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

Board Certification:

  • Immunopathology, 1983
  • Pathology - Anatomic and Clinical Pathology, 1978

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Jefferson Medical College
Fellowship: National Cancer Institute
Fellowship: American Cancer Society
Residency: Hospital of the University of Pennsylvania


American Association for Cancer Research, National American Association of Pathologists (later ASIP), National American Registry of Pathology, National American Society for Clinical Pathology (ASCP), National American Society of Investigative Pathology (ASIP); Federation of American Societies for Experimental Biology, National Arthur Purdy Stout Society of Surgical Pathologists, National Association of Anatomic and Surgical Pathology (ADASP), National College of American Pathologists (FACP), National Connective Tissue Oncology Society, International History of Pathology Society, National International Academy of Telemedicine, founding member, International International Society of Bone and Soft Tissue Pathology, International Pathology Society of Philadelphia, Local Pathology Writers Guild, Inc., National Pennsylvania Association of Pathologists, Local Royal College of Pathologists, International Society for Hematopathology, National United States & Canadian Academy of Pathology, National

Hospital Affiliation

Dr. Brooks is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Immunohistochemistry and its use in diagnosis of human diseases and tumors, including sarcomas

Selected Publications:

Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, Brennan MF, Bridge JA, Neff JR, Barr FG, Goldsmith JD, Brooks JS, Goldblum JR, Ali SZ, Shipley J, Cooper CS, Fisher C, Skytting B, Larsson O: Impact of SYT-SSX Fusion Type on the Clinical Behavior of Synovial Sarcoma: A Multi-Institutional Retrospective Study of 243 Patients Cancer Res. 62 (1): 135-140,2002.

Spiegel GW, Ashraf M, Brooks JJ: Eosinophils as a marker for invasion in cervical squamous neoplastic lesions Int. J Gynecol Pathol 21 : 117-124,2002.

Zeitoni NC, Hanna S, Loree TR, Brooks JJ, Cheney RT: Angiolymphoid Hyperplasia with eosinophilia: a case with angiosarcomatous features Dermatol Surg 28 : 772-775,2002.

Dillon DC, Easley SE, Asch BB, Cheney RT, Brydon L, Jockers R, Winston JS, Brooks JS, Hurd T, Asch HL: Differential expression of high affinity melatonin receptors (MT1) in normal and malignant breast Am J Clin Pathol 118 : 451-458,2002.

Mudhafer SA, Salameh AA, Zou HH, Ramnath N, Anderson T, Brooks JJ, Tan D: Downregulation of p21 (WAF1) in carcinogenesis and prognosis of small cell lung cancer Mod Pathol 15 : 325A,2002.

Yang J, Swede H, Malik D, Moysich K, Asch H, Brooks J, Tan D: Prognostic significance of gelsolin expression in non-small cell cancer Mod Pathol 15 : 330A,2002.

Gibbs JF, Huang PP, Lee J, McGrath B, Brooks J, McKinley B, Driscoll D, Kraybill W: Malignant Fibrous Histiocytoma: an institutional review Cancer Invest 19 : 23-27,2001.

Sait S, Brooks JJ, Ashraf M, Zhang PJ: Novel t(1;8) karyotype in a thymic carcinoma with unusual giant cell features and renal metastasis Can. Gen. Cytogen. 124 : 140-143,2001.

Chao C, Al-Saleem T, Brooks JJ, Rogatko A, Kraybill W, Eisenberg B: Vascular Endothelial Growth Factor (VEGF) and Soft Tissue Sarcomas: Tumoral Expression Correlates with Grade Ann Surg Oncol 8 : 260-267,2001.

Sabel MS, Gibbs JF, Litwin A, McGrath B, Kraybill WB, Brooks JJ: Alveolar Soft Part Sarcoma metastatic to small bowel mucosa causing polyposis and intussusception Sarcoma 5 : 133-138,2001.

Academic Contact Info

Department of Pathology
Spruce Bldg., 10th Floor
Pennsylvania Hospital
801 Spruce Street

Philadelphia, PA 19107
Phone: (215) 829-3541

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