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John V. Bosso, MD

John V. Bosso, MD Physician

Director, Otorhinolaryngology Allergy Clinic Medical Director, Penn AERD Center Clinical Associate Professor of Otorhinolaryngology: Head and Neck Surgery

Dr. Bosso is employed by Penn Medicine.

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About Dr. John V. Bosso

John V. Bosso, MD, Medical Director of the Aspirin Exacerbated Respiratory Disease (AERD) Center, is a graduate of the allergy/immunology fellowship at Scripps Clinic where the aspirin desensitization procedure was initiated and perfected, and was one of the first trainees to learn the technique. After fellowship, Dr. Bosso founded the first Regional AERD program in the New York metropolitan area and is the most experienced AERD expert in the eastern United States, successfully desensitizing over 1,000 AERD patients during his over 25 years in practice.

Recognized by America's Top Doctors for 2017

Recognized in Philadelphia magazine's May 2018 Top Docs issue

Clinical Specialties


  • Otorhinolaryngology

Programs & Centers:

Board Certification:

  • Allergy and Immunology, 1991
  • Internal Medicine, 1988

Clinical Expertise:

  • Adverse Drug Reaction
  • Allergic Granulomatous
  • Allergic Vasculitis
  • Anaphylaxis
  • Aspirin Desensitization
  • Aspirin Exacerbated Respiratory Disease (AERD)
  • Asthma
  • Contact Dermatitis (Contact Eczema)
  • Drug Allergy
  • Eczema (Atopic Dermatitis)
  • Environmental Allergy
  • Food Allergy
  • Hives (Urticaria)
  • Immune System Diseases
  • Nasal Allergy
  • Nasal Polyps
  • Sinus Disorders
  • Sinus Infections (Sinusitis)

Description of Clinical Expertise

AERD/Samter's Triad
Chronic Rhinosinusitis
Nasal polyps
Aspirin/NSAID Allergy
Aspirin Desensitization
Biologicals for Asthma, CRS, Nasal Polyps
Immunotherapy for Allergic Diseases

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: State University of New York at Buffalo
Residency: Staten Island University Hospital (North Site)
Fellowship: Scripps Green Hospital


American Academy of Allergy, Asthma & Immunology, National American College of Allergy, Asthma, and Immunology, National American Rhinology Society, National Pennsylvania Allergy Asthma and Immunology Society, Local

Hospital Affiliation

Dr. Bosso is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

AERD/Samter's Triad
Chronic Rhinosinusitis
Nasal polyps
Aspirin/NSAID Allergy
Aspirin Desensitization
Biologicals for Asthma, CRS, Nasal Polyps

Selected Publications:

John V Bosso, MD: Editorial for January 2019 issue of AJRA American Journal of Rhinology and Allergy 33 (1): 5-7,2019.

Claus Bachert, Martin Desrosiers, Joachim Mullol, Peter Hellings, Anders Cervin, Lawrence Sher, John V. Bosso, Stella Lee, Jorge F. Maspero, Shigeharu Fujieda, Shoji Matsune, Xin Lu, Chunpeng Fan Steven Draikiwicz Nikhil Amin, Siddhesh Kamat, Asif Khan, Gianluca Pirozzi, Neil M.H, Graham, Marcella Ruddy, Heribert Staudinger, Leda P. Mannent: A randomized, phase 3 study SINUS-52, evaluating the efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyposis J Allergy Clin Immunol ( submitted for late breaking abstract for AAAAI meeting 2/2019) : 2019.

Glicksman J, Parasher A, Doghramji L, Brauer D, Waldram K, Bulva J, Palmer J, Adappa N, Bosso J: Alcohol-Induced Respiratory Symptoms Improve After Aspirin Desensitization in Patients with Aspirin-Exacerbated Respiratory Disease. International Forum of Allergy and Rhinology 8 (10): 1093-1097,2018.

Shawn Radcliffe: "Allergic" to Alcohol? There may be a way to treat your symptoms. Health News : 2018.

Jared Kaltwasser: Aspirin Desensitization Reduces Alcohol-Related Respiratory Symptoms : 2018.

Janissa Delzo: Seasonal Allergies Particularly Bad in 2018 Thanks to Pollen Tsunami Teen Vogue : 2018.

Emily Rolen: Why your allergies are so bad this spring. Philly Voice : 2018.

Adappa ND, Ranasinghe VJ, Trope M, Brooks SG, Glicksman JT, Parasher AJ, Palmer JN, Bosso JV.: Outcomes after complete endoscopic sinus surgery and aspirin desensitization in aspirin-exacerbated respiratory disease. International Forum of Allergy & Rhinology 8 (1): 49-53,2018.

Patel N, Kohanski M, Maina I, Triantafillou V, Workman A, Tong CCL, Kuan EC, Bosso JV, Adappa ND, Palmer JN, Herbert D, Cohen N: Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps. International Forum of Allergy & Rhinology 00 : 1-7,2018.

Glicksman J, Bosso JV: New and Emerging Biological Medications for Asthma, Allergic Rhinitis and Chronic Rhinosinusitis: a concise review Current Otorhinolaryngology Reports 5 : 201-211,2017.

Academic Contact Info

Hospital of the University of Pennsylvania
Perelman Center for Advanced Medicine
South Pavilion, 3rd Floor
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 360-0372
Patient appointments: 800-789-7366 (PENN)